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Taltirelin

CAS No.: 103300-74-9

Chemical Name:: Taltirelin

Synonyms: TA 0910;Taltirelin;Taltireline;Ceredist, TA-0910;Taltirelin Acetate;TA-0910, taltirelin;Taltirelin (TA0910);Taltirelin USP/EP/BP;Mitragynine Impurity 2;Taltirelin interMediate

CBNumber:: CB31177191

Molecular Formula:: C17H23N7O5

Molecular Weight:: 405.41

MOL File:: 103300-74-9.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:55:04

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Taltirelin Properties

Melting point	72-75°
alpha	25D -13.6° (c = 1 in water)
Density	1.447±0.06 g/cm3(Predicted)
storage temp.	Store at +4°C
form	Solid
pka	9.32±0.40(Predicted)
color	White to off-white
Water Solubility	Soluble to 50 mM in sterile water

Taltirelin Chemical Properties,Uses,Production

Description

Taltirelin was marketed in Japan for the treatment of neurodegenerative diseases, in particular the improvement of ataxia due to spino-cerebellar degeneration (SCD); it is the first orally-active drug in this indication. This synthetic thyrotropin-releasing hormone (TRH) analog is prepared by condensation of (S)-1-methyl-4,5-dihydroorotic acid with L-histidyl-Lprolinamide. It was shown that the S-configuration for all 3 chiral centers is crucial for CNS activity. Taltirelin is a potent agonist of the TRH receptors that shows significant effects on the cerebral monoamine systems when administered i.p. in rats. As TRH at 10-fold higher doses, taltirelin has been found to increase the extracellular levels of dopamine and its metabolites (DOPAC and HVA) as well as precursors and/or metabolites of noradrenaline and serotonin in different areas of the rat brain. Taltirelin produced an anti-ataxic activity in the Rolling mouse Nagoya, an ataxic mutant mouse. In several clinical studies performed in patients suffering from various forms of SCD, taltirelin demonstrated a statistically significant increase in the global improvement of ataxic symptoms and other neurologic abnormalities.

Uses

Taltirelin is a thyrotropin-releasing hormone analog.

Biological Activity

Synthetic thyrotropin-releasing hormone (TRH) analog. Displays ~ 30-100-fold more potent CNS activity and ~ 50-fold weaker endocrine activity than TRH. Antinociceptive and neuroprotective.

Taltirelin Preparation Products And Raw materials

Raw materials

Preparation Products

Taltirelin Suppliers

Global( 145)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
Sigma Audley	+86-18336680971 +86-18126314766	China	497	58	Inquiry
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60	Inquiry
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	China	10318	58	Inquiry
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	China	3000	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49391	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29826	58	Inquiry
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	China	10297	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Pharma Affiliates	58
Sigma Audley	58
Capot Chemical Co.,Ltd.	60
Shenzhen Nexconn Pharmatechs Ltd	58
Shaanxi Pioneer Biotech Co., Ltd .	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Fuxin Pharmaceutical	58

103300-74-9(Taltirelin)Related Search:

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Thyrotropin-releasing hormone Pramlintide acetate Thymosin beta 4 Terlipressin acetate Vapreotide Acetate

Posatirelin FERTIRELIN Azetirelin Montirelin Orotirelin

Taltirelin 5,6-DIHYDRO-6-METHYLURACIL taltirelin hydrate

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Taltirelin interMediate (4S)-Hexahydro-1-Methyl-2,6-dioxo-4-pyriMidinecarbonyl-L-histidyl- Ceredist, TA-0910 TALTIRELIN INTERMEDIATES Taltirelin Acetate,TA-0910 Taltirelin L-Prolinamide, N-[(hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl)carbonyl]-L-histidyl-, (S)- L-Prolinamide, N-[[(4S)-hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl]carbonyl]-L-histidyl- (9CI) TA 0910 (4S)-N-[(2S)-1-[(2S)-2-Carbamoylpyrrolidin-1-yl]-3-(3H-imidazol-4-yl)-1-oxopropan-2-yl]-1-methyl-2,6-dioxo-1,3-diazinane-4-carboxamide 2,6-dioxo-4-pyrimidinecarbonyl-L-histidyl- L-Prolinamide,(4S)-hexahydro-1-methyl- (6S)-N-[(S)-1-[[(2S)-2-Carbamoylpyrrolizino]carbonyl]-2-(1H-imidazole-4-yl)ethyl]-2,4-dioxo-3-methylhexahydropyrimidine-6-carboxamide 1-[Nα-[[(4S)-1-Methyl-2,6-dioxohexahydropyrimidine-4-yl]carbonyl]-L-histidyl]-L-prolinamide N-[[[(4S)-1-Methyl-2,6-dioxohexahydropyrimidin]-4α-yl]carbonyl]-L-His-L-Pro-NH2 Taltireline Taltirelin Acetate 1-METHYL-4,5-DIHYDROOROTYL-HIS-PRO-NH2 TA-0910, taltirelin N-[[(4S)-Hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl]carbonyl]-L-histidyl-L-prolinamide L-Prolinamide, (4S)-hexahydro-1-methyl-2,6-dioxo-4-pyrimidinecarbonyl-L-histidyl- Taltirelin USP/EP/BP Taltirelin (TA0910) Taltirelin acetate salt Mitragynine Impurity 2 103300-74-9 C19H27N7O7 Neurochemicals Pharmaceuticals Peptide Chiral Reagents Heterocycles Intermediates & Fine Chemicals