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Taltirelin

CAS No.: 103300-74-9

Chemical Name:: Taltirelin

Synonyms: TA 0910;Taltirelin;Taltireline;Ceredist, TA-0910;Taltirelin Acetate;TA-0910, taltirelin;Taltirelin (TA0910);Taltirelin USP/EP/BP;Mitragynine Impurity 2;Taltirelin interMediate

CBNumber:: CB31177191

Molecular Formula:: C17H23N7O5

Molecular Weight:: 405.41

MOL File:: 103300-74-9.mol

MSDS File:: SDS

Modify Date:: 2024/11/19 23:02:33

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Taltirelin Properties

Melting point	72-75°
alpha	25D -13.6° (c = 1 in water)
Density	1.447±0.06 g/cm3(Predicted)
storage temp.	Store at +4°C
form	Solid
pka	9.32±0.40(Predicted)
color	White to off-white
Water Solubility	Soluble to 50 mM in sterile water

Taltirelin Chemical Properties,Uses,Production

Description

Taltirelin was marketed in Japan for the treatment of neurodegenerative diseases, in particular the improvement of ataxia due to spino-cerebellar degeneration (SCD); it is the first orally-active drug in this indication. This synthetic thyrotropin-releasing hormone (TRH) analog is prepared by condensation of (S)-1-methyl-4,5-dihydroorotic acid with L-histidyl-Lprolinamide. It was shown that the S-configuration for all 3 chiral centers is crucial for CNS activity. Taltirelin is a potent agonist of the TRH receptors that shows significant effects on the cerebral monoamine systems when administered i.p. in rats. As TRH at 10-fold higher doses, taltirelin has been found to increase the extracellular levels of dopamine and its metabolites (DOPAC and HVA) as well as precursors and/or metabolites of noradrenaline and serotonin in different areas of the rat brain. Taltirelin produced an anti-ataxic activity in the Rolling mouse Nagoya, an ataxic mutant mouse. In several clinical studies performed in patients suffering from various forms of SCD, taltirelin demonstrated a statistically significant increase in the global improvement of ataxic symptoms and other neurologic abnormalities.

Uses

Taltirelin is a thyrotropin-releasing hormone analog.

Biological Activity

Synthetic thyrotropin-releasing hormone (TRH) analog. Displays ~ 30-100-fold more potent CNS activity and ~ 50-fold weaker endocrine activity than TRH. Antinociceptive and neuroprotective.

Taltirelin Preparation Products And Raw materials

Raw materials

Preparation Products

Taltirelin Suppliers

Global( 149)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6257	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6739	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6754	58	Inquiry
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	China	29793	60	Inquiry
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	China	10311	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49374	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29810	58	Inquiry
SIMAGCHEM CORP	+86-13806087780	China	17365	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	22787	58	Inquiry
Finetech Industry Limited	+86-27-87465837 +8618971612321	China	9639	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Pharma Affiliates	58
Capot Chemical Co.,Ltd.	60
Shenzhen Nexconn Pharmatechs Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
SIMAGCHEM CORP	58
Dideu Industries Group Limited	58
Finetech Industry Limited	58

103300-74-9(Taltirelin)Related Search:

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Thyrotropin-releasing hormone Pramlintide acetate Thymosin beta 4 Terlipressin acetate Vapreotide Acetate

Posatirelin FERTIRELIN Azetirelin Montirelin Orotirelin

Taltirelin 5,6-DIHYDRO-6-METHYLURACIL taltirelin hydrate

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Taltirelin interMediate (4S)-Hexahydro-1-Methyl-2,6-dioxo-4-pyriMidinecarbonyl-L-histidyl- Ceredist, TA-0910 TALTIRELIN INTERMEDIATES Taltirelin Acetate,TA-0910 Taltirelin L-Prolinamide, N-[(hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl)carbonyl]-L-histidyl-, (S)- L-Prolinamide, N-[[(4S)-hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl]carbonyl]-L-histidyl- (9CI) TA 0910 (4S)-N-[(2S)-1-[(2S)-2-Carbamoylpyrrolidin-1-yl]-3-(3H-imidazol-4-yl)-1-oxopropan-2-yl]-1-methyl-2,6-dioxo-1,3-diazinane-4-carboxamide 2,6-dioxo-4-pyrimidinecarbonyl-L-histidyl- L-Prolinamide,(4S)-hexahydro-1-methyl- (6S)-N-[(S)-1-[[(2S)-2-Carbamoylpyrrolizino]carbonyl]-2-(1H-imidazole-4-yl)ethyl]-2,4-dioxo-3-methylhexahydropyrimidine-6-carboxamide 1-[Nα-[[(4S)-1-Methyl-2,6-dioxohexahydropyrimidine-4-yl]carbonyl]-L-histidyl]-L-prolinamide N-[[[(4S)-1-Methyl-2,6-dioxohexahydropyrimidin]-4α-yl]carbonyl]-L-His-L-Pro-NH2 Taltireline Taltirelin Acetate 1-METHYL-4,5-DIHYDROOROTYL-HIS-PRO-NH2 TA-0910, taltirelin N-[[(4S)-Hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl]carbonyl]-L-histidyl-L-prolinamide L-Prolinamide, (4S)-hexahydro-1-methyl-2,6-dioxo-4-pyrimidinecarbonyl-L-histidyl- Taltirelin USP/EP/BP Taltirelin (TA0910) Taltirelin acetate salt Mitragynine Impurity 2 103300-74-9 C19H27N7O7 Neurochemicals Pharmaceuticals Peptide Chiral Reagents Heterocycles Intermediates & Fine Chemicals