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Posatirelin

Posatirelin Structure
CAS No.
78664-73-0
Chemical Name:
Posatirelin
Synonyms
RGH-2202;BRN6006446;BRN 6006446;BRN-6006446;Posatirelin;Posatirelinum;N-[(S)-6-Oxo-2-piperidinylcarbonyl]-L-Leu-L-Pro-NH2;L-Prolinamide, (2S)-6-oxo-2-piperidinecarbonyl-L-leucyl-;N-[6-Oxopiperidin-2(S)-Ylcarbonyl]-L-Leucyl-L- Prolinamide
CBNumber:
CB51179553
Molecular Formula:
C17H28N4O4
Molecular Weight:
352.432
MOL File:
78664-73-0.mol
Modify Date:
2023/5/12 11:12:40
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Posatirelin Properties

Melting point 214-216°
alpha D25 -80.2° (c = 1 in acetic acid)
Boiling point 739.6±60.0 °C(Predicted)
Density 1.214±0.06 g/cm3(Predicted)
pka 13.56±0.20(Predicted)

Posatirelin Chemical Properties,Uses,Production

Description

Posatirelin is a TRH analogue. In a rat experimental model of brain cholinergic decit by lesion of the nucleus basalis magnocellularis (nbM), posatirelin treatment rescued cholinergic neurones of the nbM and their cholinergic projections to the cerebral cortex (Sabbatini et al., 1998). Posatirelin has been used in AD and VaD patients (Parnetti et al., 1995, 1996). VaD patients treated with posatirelin showed a signicant improvement in intellectual performance, orientation, motivation and memory as compared to controls. e drug was well tolerated.

Uses

Posatirelin is a thyrotropin-releasing hormone analogue, used in the treatment of seizures and some neurodegenerative disease such as vascular dementia and Parkinson''s disease.

Posatirelin Preparation Products And Raw materials

Raw materials

78664-34-3 2-Piperidinecarboxylic acid, 6-oxo-, 2,3,4,5,6-pentafluorophenyl ester, (2S)- L-6-HYDROXYNORLEUCINE

Preparation Products

Posatirelin Suppliers

Global( 6)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
TargetMol Chemicals Inc. 4008200310 China 24016 58 Inquiry
Lanospharma Laboratories Co.,Ltd 13440048448 China 6343 56 Inquiry
United States Biological 800.520.3011 or 781.639.5092 United States 6256 80 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58
Lanospharma Laboratories Co.,Ltd 56
United States Biological 80

78664-73-0(Posatirelin)Related Search:

N-methylpiperidine-2-carboxamide Pipecolamide Posatirelin N-ethylpiperidine-2-carboxamide
Posatirelin N-[(S)-6-Oxo-2-piperidinylcarbonyl]-L-Leu-L-Pro-NH2 RGH-2202 N-[6-Oxopiperidin-2(S)-Ylcarbonyl]-L-Leucyl-L- Prolinamide BRN 6006446 BRN6006446 BRN-6006446 Posatirelinum L-Prolinamide, (2S)-6-oxo-2-piperidinecarbonyl-L-leucyl- 78664-73-0