CARBOXYMETHYLCELLULOSE CALCIUM
- CAS No.
- 9050-04-8
- Chemical Name:
- CARBOXYMETHYLCELLULOSE CALCIUM
- Synonyms
- D03400;ecg505;Ca-CMC;hylon600;CMCCalcium;calciumcm-cellulose;calciumcelluloseglycolate;Carmellose calcium (jp15);carboxyMethyl cellose calciuM;Calciam carboxymethylceUulose
- CBNumber:
- CB8500399
- Molecular Formula:
- C23H30ClN3O
- Molecular Weight:
- 399.9568
- MOL File:
- 9050-04-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/8 17:36:13
| solubility | Practically insoluble in acetone, chloroform, ethanol (95%), toluene, and ether. Insoluble in water, but swells to form a suspension. |
|---|---|
| EPA Substance Registry System | Cellulose, carboxymethyl ether, calcium salt (9050-04-8) |
CARBOXYMETHYLCELLULOSE CALCIUM Chemical Properties,Uses,Production
Chemical Properties
DS 0.5-0.7
Uses
Pharmaceutic aid (tablet disintegrant).
Production Methods
Cellulose, obtained from wood pulp or cotton fibers, is carboxymethylated, followed by conversion to the calcium salt. It is then graded on the basis of its degree of carboxymethylation and pulverized.
Pharmaceutical Applications
The main use of carboxymethylcellulose calcium is in tablet
formulations, where it is used as a binder, diluent,
and disintegrant. Although carboxymethylcellulose calcium is
insoluble in water, it is an effective tablet disintegrant as it swells to
several times its original bulk on contact with water. Concentrations
up to 15% w/w may be used in tablet formulations; above this
concentration, tablet hardness is reduced.
Carboxymethylcellulose calcium is also used in other applications
similarly to carboxymethylcellulose sodium; for example, as a
suspending or viscosity-increasing agent in oral and topical
pharmaceutical formulations. Carboxymethylcellulose calcium is
also used in modern wound dressings for its water absorption,
retention and hemostatic properties.
Safety
Carboxymethylcellulose calcium is used in oral and topical pharmaceutical formulations, similarly to carboxymethylcellulose sodium, and is generally regarded as a nontoxic and nonirritant material. However, as with other cellulose derivatives, oral consumption of large amounts of carboxymethylcellulose calcium may have a laxative effect.
storage
Carboxymethylcellulose calcium is a stable, though hygroscopic material. It should be stored in a well-closed container in a cool, dry place.
Regulatory Status
Included in the FDA Inactive Ingredients Database (oral, capsules and tablets). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
CARBOXYMETHYLCELLULOSE CALCIUM Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| PERFECT CHEMICAL | +91-9820465461 +91-9820465461 | Mumbai, India | 391 | 58 | Inquiry |
| Dhara Industries | +91-9322395199 +91-9322395199 | Mumbai, India | 190 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| Cellulose Pharma Chem | +91-9823078051 +91-9823078051 | Maharashtra, India | 6 | 58 | Inquiry |
| Patel Industries | +91-9879997220 +91-9879997220 | Gujarat, India | 7 | 58 | Inquiry |
| Amster Microcell Pvt Ltd | +91-8758675180 +91-9714592808 | Gujarat, India | 9 | 58 | Inquiry |
| Prachin Chemical | +91-7922821740 +91-9825015645 | Gujarat, India | 21 | 58 | Inquiry |
| Patel Chem Specialities Pvt Ltd | +91-7929709854 +91-9099010967 | Gujarat, India | 8 | 58 | Inquiry |
| Maple Biotech Pvt Ltd | +91-7720034271 +91-9822018722 | Maharashtra, India | 7 | 58 | Inquiry |
| Arihant Innochem Pvt Ltd | +91-2267674895 +91-2267674895 | Mumbai, India | 37 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| PERFECT CHEMICAL | 58 |
| Dhara Industries | 58 |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | 58 |
| Cellulose Pharma Chem | 58 |
| Patel Industries | 58 |
| Amster Microcell Pvt Ltd | 58 |
| Prachin Chemical | 58 |
| Patel Chem Specialities Pvt Ltd | 58 |
| Maple Biotech Pvt Ltd | 58 |
| Arihant Innochem Pvt Ltd | 58 |
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