Sodium carboxymethyl cellulose
- CAS No.
- 9004-32-4
- Chemical Name:
- Sodium carboxymethyl cellulose
- Synonyms
- Carboxymethyl cellulose;CMC-Na;cellulose gum;carmellose sodium;b10;carbo;Carboxyl Methyl Cellulose sodium;cmc2;Color Speckles;Cellex
- CBNumber:
- CB5209844
- Molecular Formula:
- C6H7O2(OH)2CH2COONa
- Molecular Weight:
- 0
- MOL File:
- 9004-32-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/29 17:48:59
| Melting point | 274 °C (dec.) |
|---|---|
| Density | 1,6 g/cm3 |
| FEMA | 2239 | CARBOXYMETHYLCELLULOSE |
| storage temp. | room temp |
| solubility | H2O: 20 mg/mL, soluble |
| form | low viscosity |
| pka | 4.30(at 25℃) |
| color | White to light yellow |
| PH | pH (10g/l, 25℃) 6.0～8.0 |
| Odor | Odorless |
| PH Range | 6.5 - 8.5 |
| Water Solubility | soluble |
| Merck | 14,1829 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| EPA Substance Registry System | Sodium carboxymethyl cellulose (9004-32-4) |
Sodium carboxymethyl cellulose price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR2726 | Carboxymethylcellulose Sodium certified reference material, pharmaceutical secondary standard | 9004-32-4 | 2G | ₹11117.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C9481 | Carboxymethylcellulose sodium meets USP testing specifications, Medium viscosity | 9004-32-4 | 1KG | ₹14483.85 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C5678 | Carboxymethylcellulose sodium salt low viscosity | 9004-32-4 | 500G | ₹11110 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C9481 | Carboxymethylcellulose sodium meets USP testing specifications, Medium viscosity | 9004-32-4 | 500G | ₹15717.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C5678 | Carboxymethylcellulose sodium salt low viscosity | 9004-32-4 | 1KG | ₹17536.5 | 2022-06-14 | Buy |
Sodium carboxymethyl cellulose Chemical Properties,Uses,Production
Chemical Properties
Carboxymethylcellulose sodium occurs as a white to almost white, odorless, tasteless, granular powder. It is hygroscopic after drying.
Uses
In drilling muds, in detergents as a soil-suspending agent, in resin emulsion paints, adhesives, printing inks, textile sizes, as protective colloid in general. As stabilizer in foods. Pharmaceutic aid (suspending agent; tablet excipient; viscosity-increasing agent).
Production Methods
Alkali cellulose is prepared by steeping cellulose obtained from wood pulp or cotton fibers in sodium hydroxide solution. The alkaline cellulose is then reacted with sodium monochloroacetate to produce carboxymethylcellulose sodium. Sodium chloride and sodium glycolate are obtained as by-products of this etherification.
Definition
A semisynthetic, water-soluble polymer in which CH 2 COOH groups are substituted on the glucose units of the cellulose chain through an ether link- age. Mw ranges from 21,000 to 500,000. Since the reaction occurs in an alkaline medium, the prod- uct is the sodium salt of the carboxylic acid R-O- CH 2 COONa.
General Description
Sodium carboxymethyl cellulose (CMC) belongs to the class of anionic linear structured cellulose. Its components consist of polysaccharide composed of fibrous tissues of plants. It is a water soluble polymer which can be used as a polyelectrolyte cellulose derivative.
Pharmaceutical Applications
Sodium carboxymethyl cellulose (NaCMC) is the sodium salt of carboxymethyl cellulose, an anionic derivative.It is widely used in oral and topical pharmaceutical formulations, primarily for its viscosity-increasing properties. Viscous aqueous solutions are used to suspend powders intended for either topical application or oral and parenteral administration. Carboxymethylcellulose sodium may also be used as a tablet binder and disintegrant, and to stabilize emulsions.
Higher concentrations, usually 3–6%, of the medium-viscosity grade are used to produce gels that can be used as the base for applications and pastes; glycols are often included in such gels to prevent them drying out. Carboxymethylcellulose sodium is also used in self-adhesive ostomy, wound care, and dermatological patches as a muco-adhesive and to absorb wound exudate or transepidermal water and sweat. This muco-adhesive property is used in products designed to prevent post-surgical tissue adhesions; and to localize and modify the release kinetics of active ingredients applied to mucous membranes; and for bone repair. Encapsulation with carboxymethylcellulose sodium can affect drug protection and delivery. There have also been reports of its use as a cyto-protective agent.
Carboxymethylcellulose sodium is also used in cosmetics, toiletries, surgical prosthetics, and incontinence, personal hygiene, and food products.
Safety Profile
Mildly toxic by ingestion. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. It migrates to food from packagmg materials. When heated to decomposition it emits toxic fumes of NazO. See also POLYMERS, SOLUBLE.
Safety
Carboxymethylcellulose sodium is used in oral, topical, and some
parenteral formulations. It is also widely used in cosmetics,
toiletries, and food products, and is generally regarded as a
nontoxic and nonirritant material. However, oral consumption of
large amounts of carboxymethylcellulose sodium can have a
laxative effect; therapeutically, 4–10 g in daily divided doses of the
medium- and high-viscosity grades of carboxymethylcellulose
sodium have been used as bulk laxatives.
The WHO has not specified an acceptable daily intake for
carboxymethylcellulose sodium as a food additive since the levels
necessary to achieve a desired effect were not considered to be a
hazard to health. However, in animal studies, subcutaneous
administration of carboxymethylcellulose sodium has been found to
cause inflammation, and in some cases of repeated injection
fibrosarcomas have been found at the site of injection.
Hypersensitivity and anaphylactic reactions have occurred in
cattle and horses, which have been attributed to carboxymethylcellulose
sodium in parenteral formulations such as vaccines and
penicillins.
LD50 (guinea pig, oral): 16 g/kg
LD50 (rat, oral): 27 g/kg
storage
Carboxymethylcellulose sodium is a stable, though hygroscopic
material. Under high-humidity conditions, carboxymethylcellulose
sodium can absorb a large quantity (>50%) of water. In tablets, this
has been associated with a decrease in tablet hardness and an
increase in disintegration time.
Aqueous solutions are stable at pH 2–10; precipitation can occur
below pH 2, and solution viscosity decreases rapidly above pH 10.
Generally, solutions exhibit maximum viscosity and stability at pH
7–9.
Carboxymethylcellulose sodium may be sterilized in the dry state
by maintaining it at a temperature of 1608℃ for 1 hour. However,
this process results in a significant decrease in viscosity and some
deterioration in the properties of solutions prepared from the
sterilized material.
Aqueous solutions may similarly be sterilized by heating,
although this also results in some reduction in viscosity. After
autoclaving, viscosity is reduced by about 25%, but this reduction is
less marked than for solutions prepared from material sterilized in
the dry state. The extent of the reduction is dependent on the
molecular weight and degree of substitution; higher molecular
weight grades generally undergo a greater percentage reduction in
viscosity. Sterilization of solutions by gamma irradiation also
results in a reduction in viscosity.
Aqueous solutions stored for prolonged periods should contain
an antimicrobial preservative.
The bulk material should be stored in a well-closed container in a
cool, dry place.
Purification Methods
Dialyse it for 48hours against distilled water and freeze-dry if a solid is required.
Incompatibilities
Carboxymethylcellulose sodium is incompatible with strongly
acidic solutions and with the soluble salts of iron and some other
metals, such as aluminum, mercury, and zinc. It is also incompatible
with xanthan gum. Precipitation may occur at pH < 2, and also
when it is mixed with ethanol (95%).
Carboxymethylcellulose sodium forms complex coacervates
with gelatin and pectin. It also forms a complex with collagen
and is capable of precipitating certain positively charged proteins.
Regulatory Status
GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (dental preparations; intraarticular, intrabursal, intradermal, intralesional, and intrasynovial injections; oral drops, solutions, suspensions, syrups and tablets; topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.
Sodium carboxymethyl cellulose Preparation Products And Raw materials
Raw materials
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Atul Intermediates | +91-7940399111 +91-9825071644 | Gujarat, India | 24 | 58 | Inquiry |
| UNILOSA INTERNATINAL PRIVATE LIMITED | +91-9999069917 +91-9999069917 | New Delhi, India | 152 | 58 | Inquiry |
| HRV Global Life Sciences | +91-9820219686 +91-9820219686 | Telangana, India | 379 | 58 | Inquiry |
| Sujata Chemicals | +91-9898025496 +91-9898025496 | Gujarat, India | 73 | 58 | Inquiry |
| Indenta Chemicals (India) Pvt Ltd | +91-2226849600 +91-9326627752 | Maharashtra, India | 48 | 58 | Inquiry |
| A.B.ENTERPRISES | +91-9223381464 +91-9223381464 | Maharashtra, India | 78 | 58 | Inquiry |
| Sri Chemicals | +91-4426207575 +91-4442127722 | Tamil Nadu, India | 21 | 58 | Inquiry |
| Cellulose Pharma Chem | +91-9823078051 +91-9823078051 | Maharashtra, India | 6 | 58 | Inquiry |
| NB Entrepreneurs | +91-9970018645 +91-9970057654 | Maharashtra, India | 7 | 58 | Inquiry |
| Patel Industries | +91-9879997220 +91-9879997220 | Gujarat, India | 7 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Atul Intermediates | 58 |
| UNILOSA INTERNATINAL PRIVATE LIMITED | 58 |
| HRV Global Life Sciences | 58 |
| Sujata Chemicals | 58 |
| Indenta Chemicals (India) Pvt Ltd | 58 |
| A.B.ENTERPRISES | 58 |
| Sri Chemicals | 58 |
| Cellulose Pharma Chem | 58 |
| NB Entrepreneurs | 58 |
| Patel Industries | 58 |
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