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CALCIPOTRIOL MONOHYDRATE

CAS No.: 147657-22-5

Chemical Name:: CALCIPOTRIOL MONOHYDRATE

Synonyms: Calcipotriol monohydrate CRS;CALCIPOTRIOL MONOHYDRATE;Calcipotriol (Calcipotriene) Monohydrate;(5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1α,3β,24-triol;(1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-1-((2R,5S,E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol hydrate;(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-Cyclohexanediol hydrate;(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-Cyclohexanediol monohydrate;1,3-Cyclohexanediol,5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-,hydrate (1:1), (1R,3S,5Z)-

CBNumber:: CB8588339

Molecular Formula:: C27H42O4

Molecular Weight:: 430.63

MOL File:: 147657-22-5.mol

Modify Date:: 2024/7/2 8:55:37

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CALCIPOTRIOL MONOHYDRATE Properties

storage temp.	4°C, protect from light, stored under nitrogen,unstable in solution, ready to use.
solubility	Practically insoluble in water, freely soluble in ethanol (96 per cent), slightly soluble in methylene chloride.
form	Powder
color	White to off-white
Stability	Hygroscopic, Light sensitive
InChIKey	XBKHACNRWFKJNC-IZXATKCONA-N
SMILES	C[C@]12CCC/C(=C\C=C3\C[C@@H](O)C[C@H](O)C\3=C)/[C@]1([H])CC[C@]2([H])[C@H](C)/C=C/[C@H](C1CC1)O.O \|&1:1,10,13,17,21,23,27,r\|

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H310

Precautionary statements

P262-P264-P270-P280-P302+P350-P310-P322-P361-P363-P405-P501

NFPA 704

	0
4		0

CALCIPOTRIOL MONOHYDRATE Chemical Properties,Uses,Production

Description

Calcipotriol (hydrate) is a low-calcemic vitamin D receptor (VDR) agonist. Calcipotriol (hydrate) is about 200 times less potent in its effects on calcium metabolism than vitamin D (1,25[OH]D₃). Binding of calcipotriol (hydrate) to the VDR increases AP-1, a transcription factor important for keratinocyte differentiation, and reduces expression of JunB protein, a transcriptional activator in the inflammatory response. Calcipotriol (hydrate) also induces expression of thymic stromal lymphopoietin, which triggers T-cell differentiation in keratinocytes.

Chemical Properties

White or almost white, crystalline powder.

Uses

Vitamin D analogue.

Definition

ChEBI: A hydrate that is the monohydrate form of calcipotriol. It is used in combination with betamethasone dipropionate, a corticosteroid, for the topical treatment of plaque psoriasis in adult patients.

CALCIPOTRIOL MONOHYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products

CALCIPOTRIOL MONOHYDRATE Suppliers

Global( 143)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Flax Laboratories	+91-9867665132 +91-9867665132	Maharashtra, India	44	58	Inquiry
EAGLE CHEMICAL WORKS	+91-22263303652226330365 +91-2226330365	Maharashtra, India	61	58	Inquiry
DK Pharmachem Pvt Ltd	+91-2242153111 +91-2242153111	Maharashtra, India	37	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Shri Siddhivinayak Agencies	09767556611	Maharashtra, India	1	58	Inquiry
SR Chemexon Pharmachem	08048372661Ext 585	Gujarat, India	27	58	Inquiry
Triveni Interchem Private Limited (Group Of Triveni...	08046042087	Gujarat, India	497	58	Inquiry
Rhyme Organics And Chemicals Limited	08048372046Ext 929	Hyderabad, India	102	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry

Supplier	Advantage
Flax Laboratories	58
EAGLE CHEMICAL WORKS	58
DK Pharmachem Pvt Ltd	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Shri Siddhivinayak Agencies	58
SR Chemexon Pharmachem	58
Triveni Interchem Private Limited (Group Of Triveni...	58
Rhyme Organics And Chemicals Limited	58
CLEARSYNTH LABS LTD.	58
Pharma Affiliates	58

147657-22-5(CALCIPOTRIOL MONOHYDRATE)Related Search:

(2E,4R)-4-[(1R,3aS,4E,7aR)-4-[(2E)-2-[(3S,5R)-3,5-Bis[[(tert-butyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-cyclopropyl-2-penten-1-one Carboplatin CALCIUM THIOGLYCOLATE TRIHYDRATE Calcipotriene Calcipotriene

CALCIPOTRIOL MONOHYDRATE (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-Cyclohexanediol hydrate (5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1α,3β,24-triol (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-Cyclohexanediol monohydrate 1,3-Cyclohexanediol,5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-,hydrate (1:1), (1R,3S,5Z)- Calcipotriol (Calcipotriene) Monohydrate (1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-1-((2R,5S,E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol hydrate Calcipotriol monohydrate CRS 147657-22-5 C27H40O3H2O API API intermediates