Carboplatin
- CAS No.
- 41575-94-4
- Chemical Name:
- Carboplatin
- Synonyms
- PARAPLATIN;cbdca;Carboplat;1,1-cyclobutanedicarboxylatediammineplatinum(ii);JM-8;Ercar;CarbopL;NSC-17102;nsc-241240;CARBOPLATIN
- CBNumber:
- CB6702418
- Molecular Formula:
- C6H12N2O4Pt
- Molecular Weight:
- 371.25
- MOL File:
- 41575-94-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/10 19:09:13
| Melting point | 228-230°C |
|---|---|
| storage temp. | 2-8°C |
| solubility | Sparingly soluble in water, very slightly soluble in acetone and in ethanol (96 per cent). |
| form | crystal |
| color | white |
| Water Solubility | Soluble in water. |
| Merck | 14,1822 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChI | InChI=1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2/p-2 |
| InChIKey | OLESAACUTLOWQZ-UHFFFAOYSA-L |
| SMILES | C12(CCC1)C(=O)O[Pt]OC2=O.N.N |
| EPA Substance Registry System | Carboplatin (41575-94-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302+H312+H332-H317-H334-H340-H360 | |||||||||
| Precautionary statements | P201-P280-P301+P312-P302+P352+P312-P304+P340+P312-P308+P313 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 46-61-20/21/22-42/43-20/21 | |||||||||
| Safety Statements | 53-22-26-36/37/39-45 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TP2300000 | |||||||||
| HS Code | 28439000 | |||||||||
| Toxicity | LD50 in mice (mg/kg): 150 i.p., 140 i.v.; in rats (mg/kg): 85 i.v. (Lelieveld) | |||||||||
| NFPA 704 |
|
Carboplatin price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C2538 | Carboplatin | 41575-94-4 | 100MG | ₹22200 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR3417 | Carboplatin certified reference material, pharmaceutical secondary standard | 41575-94-4 | 200MG | ₹23276.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C2538 | Carboplatin | 41575-94-4 | 250MG | ₹44899.5 | 2022-06-14 | Buy |
| TCI Chemicals (India) | C2043 | Carboplatin | 41575-94-4 | 100MG | ₹4000 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C2043 | Carboplatin | 41575-94-4 | 1G | ₹21800 | 2022-05-26 | Buy |
Carboplatin Chemical Properties,Uses,Production
Description
Carboplatin is a second generation, platinum-containing antineoplastic agent with significantly reduced nephro-, neuro-, and ototoxicity in comparison to cisplatin. It is effective in the treatment of advanced ovarian carcinoma of epithelial origin and small cell carcinoma of the lung.
Chemical Properties
White Crystals
Uses
Data on carboplatin production have not been found. Carboplatin is used in chemotherapy to treat cancer, and more particularly to treat cancer of ovary, embryonal carcinoma of the testis, microcellular carcinoma of the lung, neuroblastoma, and squamous cell carcinomas of the head and neck.
Indications
Carboplatin (Paraplatin) is an analogue of cisplatin. Its
plasma half-life is 3 to 5 hours, and it has no significant
protein binding. Renal excretion is the major route of
drug elimination.
Despite its lower chemical reactivity, carboplatin
has antitumor activity that is similar to that of cisplatin
against ovarian carcinomas, small cell lung cancers,
and germ cell cancers of the testis. Most tumors that
are resistant to cisplatin are cross-resistant to carboplatin.
The major advantage of carboplatin over cisplatin is
a markedly reduced risk of toxicity to the kidneys, peripheral
nerves, and hearing; additionally, it produces
less nausea and vomiting. It is, however, more myelosuppressive
than cisplatin. Other adverse effects include
anemia, abnormal liver function tests, and occasional allergic
reactions.
General Description
Carboplatin is available in 50-, 150-, and 450-mg vials for IVadministration in the treatment of ovarian cancer, bladdercancer, germ cell tumors, head and neck cancers, small celllung cancer, and NSCLC. Activation of the agent occurs byaquation in a manner similar to that seen for cisplatin. Thepresence of the chelating 1,1-cyclobutane-dicarboxylateslows this reaction 100-fold and reduces the toxicity of theagent. The sites of alkylation and mechanisms of resistanceare like those seen for cisplatin, and the two agents showcross-resistance. The agent is widely distributed upon IV administration but, because of its greater stability, it bindsslowly to plasma proteins, requiring 24 hours to reach 90%bound drug compared with 4 hours for cisplatin. The agent iseliminated in the urine with a terminal elimination half-lifeof 2 to 6 hours. Adverse effects include myelosuppression,which is dose limiting. Other adverse effects include renaltoxicity, nausea, vomiting, and peripheral neuropathy, butthese occur much less frequently than with cisplatin.
Pharmaceutical Applications
Carboplatin, cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II), is a second-generation platinum drug.
Its structure is based on cisplatin with the difference that the chloride ligands are exchanged for a bidentate
chelating ligand. A consequence is that carboplatin is less reactive than cisplatin and therefore is less nephrotoxic
and orthotoxic than the parent compound. Unfortunately, it is more myelosuppressive than cisplatin,
which reduces the patients’ white blood cell count and makes them susceptible to infections. Carboplatin
was licensed by the FDA in 1989 under the brand name Paraplatin and has since then gained worldwide
recognition. Carboplatin on its own or in combination with other anticancer agents is used in the treatment
of a variety of cancer types including head and neck, ovarian, small-cell lung, testicular cancer and others.
Carboplatin is a pale-white solid showing good aqueous solubility. The synthesis starts with potassium
tetrachloroplatinate, which is reacted to the orange [PtI4]2- anion.
Biological Activity
Antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Enhances radiation-induced single-strand DNA breakage and displays lower nephrotoxicity than analog cisplatin (cis-Diaminodichloroplatinum ).
Mechanism of action
Carboplatin, another square planar Pt(II) complex, forms the same cytotoxic hydrated intermediate as cisplatin but does so at a slower rate, making it a less potent chemotherapeutic agent.
Clinical Use
This drug induces fewer nonhematological toxicities (e.g., emesis, nephrotoxicity, and ototoxicity) compared to cisplatin, and it is approved for use only in the treatment of ovarian cancer. Unlabeled uses include combination therapy in lung, testicular, and head and neck cancers.
Side effects
The ultimate damage done to cells as a result of carboplatin use, however, approaches that of cisplatin. The plasma half-life of carboplatin is 3 hours, and the drug is less extensively bound to serum proteins. Excretion is predominantly renal, and doses must be reduced in patients with kidney disease. Suppression of platelets and white blood cells is the most significant toxic reaction of carboplatin use.
Carboplatin Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Jigs Chemical ltd | +919099003427 | Gujarat, India | 239 | 58 | Inquiry |
| AVD pharmaceuticals Pvt Ltd | +919860835260 | Pune, India | 102 | 58 | Inquiry |
| Bulat Pharmaceutical Pvt Ltd | +91-8448085659 +91-8448085660 | Haryana, India | 123 | 58 | Inquiry |
| Arora Matthey Limited | +91-9830058614 +91-9830058614 | West Bengal, India | 24 | 58 | Inquiry |
| Cipla Ltd | +912224826000 | Maharashtra, India | 133 | 58 | Inquiry |
| Sun Pharmaceutical Industries Ltd | +91-2242244224 +91-2243244324 | Maharashtra, India | 108 | 58 | Inquiry |
| Green Vision Life Sciences Pvt Ltd. | +91-2067919200 +91-9404953243 | Maharashtra, India | 30 | 58 | Inquiry |
| Raising Sun Pharma | +91-9399941155 +91-9399941155 | Telangana, India | 127 | 58 | Inquiry |
| Laurus Labs Ltd | +91-4066594333 +91-4039804333 | Telangana, India | 50 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Jigs Chemical ltd | 58 |
| AVD pharmaceuticals Pvt Ltd | 58 |
| Bulat Pharmaceutical Pvt Ltd | 58 |
| Arora Matthey Limited | 58 |
| Cipla Ltd | 58 |
| Sun Pharmaceutical Industries Ltd | 58 |
| Green Vision Life Sciences Pvt Ltd. | 58 |
| Raising Sun Pharma | 58 |
| Laurus Labs Ltd | 58 |
| Ralington Pharma | 58 |
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