Drospirenone
- CAS No.
- 67392-87-4
- Chemical Name:
- Drospirenone
- Synonyms
- Drospirenon;Drospirenona;DROSPIRENONE INTERMEDIATE;17-Hydroxy-7β-(hydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21-carboxylic Acid, -Lactone;6b,7b;ZK 3059;ZK 30595;Spironone;Drospirone;arbolactone
- CBNumber:
- CB8695608
- Molecular Formula:
- C24H30O3
- Molecular Weight:
- 366.5
- MOL File:
- 67392-87-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/7 11:37:32
| Melting point | 196-200°C |
|---|---|
| alpha | -180 º (c=0.5, chloroform) |
| Boiling point | 552.2±50.0 °C(Predicted) |
| Density | 1.26±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥15 |
| form | powder |
| color | white to tan |
| optical activity | [α]/D -180 to -195°, c = 1 in methanol |
| InChIKey | METQSPRSQINEEU-URUUTGNFNA-N |
| SMILES | C[C@]12CC[C@]3([H])[C@]4(CCC(=O)C=C4[C@@H]4C[C@@H]4[C@@]3([H])[C@]1([H])[C@@H]1C[C@@H]1[C@]12CCC(=O)O1)C |&1:1,4,6,13,15,16,18,20,22,23,r| |
Drospirenone price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0147 | Drospirenone ≥98% (HPLC) | 67392-87-4 | 10MG | ₹9742.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0147 | Drospirenone ≥98% (HPLC) | 67392-87-4 | 50MG | ₹38417.93 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR3314 | Drospirenone certified reference material, pharmaceutical secondary standard | 67392-87-4 | 500MG | ₹18586.53 | 2022-06-14 | Buy |
| TCI Chemicals (India) | D4209 | Drospirenone | 67392-87-4 | 200MG | ₹9500 | 2022-05-26 | Buy |
Drospirenone Chemical Properties,Uses,Production
Description
The steroid drospirenone in combination with the estrogen agonist ethinylestradiol was introduced in Germany as a new oral contraceptive for women. This analog of the aldosterone antagonist spironoiactone can be synthesized in five steps from 3β-hydroxy- 15β,16β-methylene-5-androsten-l7-one. Since its binding profile for steroid receptors is very similar to progesterone, drospirenone mimics the progestogen agonistic activity as well as the anti-androgenic and anti-mineralocorticoid properties of the endogenous hormone. In rats, drospirenone inhibited ovulation at 6.3 mglkglday p.o. Compared with currently available progestins which lack anti-mineralocorticoid activity, drospirenone did not cause weight gain that could result from fluid retention in clinical studies. Its combination with ethinylestradiol was well tolerated and did not engender adverse effects on blood pressure or plasma lipid levels. Drospirenone is rapidly absorbed in man with an oral bioavailability of 76%. It is extensively metabolized since over 20 different metabolites were observed in the urine and in the feces, resulting for instance from hydrolysis of the lactone in the plasma or reductive conjugation of the enone to the 3-sulfate ester of 45 dihydrodrospirenone. Its elimination is bi-exponential with an initial and a terminal half-life of 2 and 25-33h respectively.
Chemical Properties
Off-White Crystalline Powder
Uses
Drospirenone has been used as a progestogen agent in pond snail and fish.
General Description
Drospirenone, 3-oxo-6β,7β:15β,16β-dimethylene-17α-pregn-4-en-21,17-carbolactone,differs structurally from all the other commercially availableprogestins. Its structure is similar to that of spironolactone,an MR antagonist, and it does have antimineralocorticoidactivity as well as progestational activity. It isalso reported to have some antiandrogenic effects. Thespirolactone at C17 and the two cyclopropyl groups at C6-C7 and C15-C16 contribute to these unique actions.Drospirenone is the progestin component in the newer oralcontraceptives, Yasmin and Yaz, and in the HRT product,Angeliq.
Drospirenone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Lupin Ltd | +91-8019896181 +91-8019896181 | Maharashtra, India | 93 | 58 | Inquiry |
| Sun Pharmaceutical Industries Ltd | +91-2242244224 +91-2243244324 | Maharashtra, India | 108 | 58 | Inquiry |
| Swati Spentose Pvt Ltd | +91-2261505232 +91-2261505232 | Maharashtra, India | 44 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| BDR Pharmaceuticals International Pvt Ltd | +91-2240560560 +91-7718884418 | Maharashtra, India | 206 | 58 | Inquiry |
| Symbiotec Pharma Lab Pvt Ltd | +91-7316676406 +91-7316676405 | Madhya Pradesh, India | 71 | 58 | Inquiry |
| AKASH PHARMA EXPORTS | +91-9388123451 +91-9846039283 | Kerela, India | 470 | 58 | Inquiry |
| BDR Pharmaceuticals International Pvt., Ltd. | 91-22-40560560 | Maharashtra, India | 91 | 58 | Inquiry |
| Archerchem Healthcare Pvt., Ltd. (part of Archerchem Group) | 91-22-42361111 | Maharashtra, India | 147 | 58 | Inquiry |
| Shree Raj Chem | 08048372913Ext 682 | Mumbai, India | 91 | 58 | Inquiry |
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