(-)PPP
- CAS No.
- 477-47-4
- Chemical Name:
- (-)PPP
- Synonyms
- (-)PPP;(-)PPP;AXL1717;AXL 1717;AXL-1717;NSC 36407;Metacavir;PICROPODOPHYLLIN;(-)PPP USP/EP/BP;Pictopodophyllotoxin
- CBNumber:
- CB8708520
- Molecular Formula:
- C22H22O8
- Molecular Weight:
- 414.41
- MOL File:
- 477-47-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/23 17:50:46
| Melting point | 225-227℃ |
|---|---|
| alpha | D20 +9.4° (c = 0.7 in chloroform) |
| Boiling point | 453.31°C (rough estimate) |
| Density | 1.370 |
| refractive index | 1.4480 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | H2O: soluble |
| form | powder |
| pka | 13.26±0.40(Predicted) |
| color | white |
| Sensitive | Light Sensitive |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H312-H315-H319-H335 |
| Precautionary statements | P261-P264-P280-P301+P310-P302+P352+P312-P305+P351+P338 |
| Hazard Codes | Xi,T |
| Risk Statements | 36/37/38-68-25-21 |
| Safety Statements | 26-36-45-36/37 |
| RIDADR | UN 3462 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | LV2510000 |
| HazardClass | 6.1 |
| Toxicity | LD50 intraperitoneal in mouse: 280mg/kg |
(-)PPP price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T9576 | Picropodophyllotoxin ≥96% (HPLC), powder | 477-47-4 | 1MG | ₹14234.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T9576 | Picropodophyllotoxin ≥96% (HPLC), powder | 477-47-4 | 5MG | ₹57415.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 407247 | IGF-1R Inhibitor, PPP - CAS 477-47-4 - Calbiochem The IGF-1R Inhibitor, PPP, also referenced under CAS 477-47-4, controls the biological activity of IGF-1R. This small molecule/inhibitor is primarily | 477-47-4 | 1MG | ₹17000 | 2022-06-14 | Buy |
(-)PPP Chemical Properties,Uses,Production
Uses
Insulin growth factor 1 receptor inhibitor, antineoplastic
Definition
ChEBI: An organic heterotetracyclic compound that has a furonaphthodioxole skeleton bearing 3,4,5-trimethoxyphenyl and hydroxy substituents.
General Description
Poly(2,5-bis(3-sulfonatopropoxy)-1,4-phenylene, disodium salt-alt-1,4-phenylene) (PPP-OPSO3) is a water soluble conjugating polymer that can be used as a donor molecule. It has a poly(p-phenylene) skeleton with each repeating unit having two phenylene groups. It can be used for a variety of optoelectronic applications.
Biological Activity
Orally active insulin-like growth factor 1 receptor (IGF1R) inhibitor that exhibits no activity at the insulin receptor, FGFR, PDGFR or EGFR. Inhibits IGF1R autophosphorylation (IC 50 ~ 1 nM), increases the fraction of cells in the G 2 /M phase and upregulates apoptosis. Exhibits antiproliferative effects in multiple cancer cell lines (IC 50 = 0.05 - 15 μ M), and has anticancer and antineovascularization activity in vivo .
(-)PPP Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 153)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Nandani Enterprise | 09067820072 | Gujarat, India | 1 | 58 | Inquiry |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | China | 3777 | 58 | Inquiry |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | China | 2995 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | China | 11506 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23556 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24639 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
477-47-4((-)PPP)Related Search:
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ETHYL 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONATE
(-)PPP
3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID
Anwuligan
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PICROPODOPHYLLIN
(-)PPP
POLY(2,5-BIS(3-SULFONATOPROPOXY)-1,4-PHENYLENE, DISODIUM SALT-ALT-1,4-PHENYLENE)
NSC 36407, Picropodophyllin, PPP, (5R,5aS,8aR,9R)-9-Hydroxy-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)furo[3μ,4μ:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
(5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
IGF-1R Inhibitor, PPP
(5R,5aS,8aR,9R)-9-Hydroxy-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)fur[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
NSC 36407
Pictopodophyllotoxin
AXL 1717
AXL1717
AXL-1717
(5R,5aS,8aR,9R)-9-Hydroxy-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
Picropodophyllotoxin, >=98%
Metacavir
AXL1717 (Picropodophyllotoxin)
IGF-1R Inhibitor, PPP - CAS 477-47-4 - Calbiochem
Picropodophyllin (AXL1717)
Podophyllotoxin 5a-Epimer
Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R,5aS,8aR,9R)-
(-)PPP USP/EP/BP
Picropodophyllin (Picropodophyllotoxin, AXL-1717 or PPP)
(5R,5aS,9R)-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-te...
(5R,5aS,8aR,9R)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
(-)PPP
Bitter Podophyllotoxin
(5R,5aS,8aR,9R)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
477-47-4
Insulin-like Growth Factor-1 Receptor Inhibitor
Picropodophyllin