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FK 888

FK 888 Structure
CAS No.
138449-07-7
Chemical Name:
FK 888
Synonyms
FK 888;FK888 hydrate;N(2)-(4-Hydroxy-1-(1-methyl-1H-indol-3-yl)carbonyl-L-prolyl)-N-methyl-N-phenylmethyl-3-(2-naphthyl)-L-alaninamide;(4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide;L-Alaninamide, (4R)-4-hydroxy-1-((1-methyl-1H-indol-3-yl)carbonyl)-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-;L-Alaninamide, trans-4-hydroxy-1-((1-methyl-1H-indol-3-yl)carbonyl)-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-;N2-[(4R)-4-hydroxyl-1-(1-methyl-1H-indol-3-yl)carbonyl-L-prolyl]-N-methyl-N-phenylmethyl-3-(2-naphthyl)-L-alaninamide hydrate;(4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide hydrate
CBNumber:
CB8785831
Molecular Formula:
C36H36N4O4
Molecular Weight:
588.7
MOL File:
138449-07-7.mol
Modify Date:
2023/6/30 15:45:59
Request For Quotation

FK 888 Properties

Boiling point 901.9±65.0 °C(Predicted)
Density 1.26±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: ≥13mg/mL
form powder
pka 13.01±0.40(Predicted)
color white to tan
optical activity [α]/D -135 to -145°, c = 1 in methanol

SAFETY

Risk and Safety Statements

WGK Germany  3

FK 888 Chemical Properties,Uses,Production

Uses

FK 888 is a neurokinin NK1 receptor antagonist, which is active both in vivo and in vitro.

Biological Activity

Selective, high affinity tachykinin NK 1 receptor antagonist (K i = 0.69 nM) that displays 320-fold selectivity for human over rat NK 1 receptors. Inhibits substance P-induced contraction of isolated guinea pig trachea (IC 50 = 32 nM) and inhibits substance P-induced airway constriction in vivo following i.v. and oral administration.

FK 888 Preparation Products And Raw materials

Raw materials

Preparation Products

FK 888 Suppliers

Global( 22)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd. +86-057181025280; +8617767106207 China 49739 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
RD International Technology Co., Limited 18024082417 China 9155 58 Inquiry
TargetMol Chemicals Inc. 4008200310 China 24017 58 Inquiry
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 China 4398 58 Inquiry
Service Chemical Inc. 888-895-6920 Germany 6373 71 Inquiry
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 China 15848 69 Inquiry
Riedel-de Haen AG 800 558-9160 United States 6825 87 Inquiry
Tocris Bioscience +44 (0) 117 916 3333 United Kingdom 5729 77 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 58
Aladdin Scientific 58
RD International Technology Co., Limited 58
TargetMol Chemicals Inc. 58
Nantong QuanYi Biotechnology Co., Ltd 58
Service Chemical Inc. 71
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Riedel-de Haen AG 87
Tocris Bioscience 77

FK 888 Spectrum

FK 888(138449-07-7)MSFK 888(138449-07-7)IR1FK 888(138449-07-7)IR2

138449-07-7(FK 888)Related Search:

3-(NAPHTHALEN-2-YL)PROPAN-1-AMINE 2-NAPHTHALEN-2-YL-ETHYLAMINE (1-Methyl-1H-indol-3-yl)-methylamine 1H-PYRROLE-3-METHANAMINE, 1-METHYL- 1H-Indole-3-carboxamide(9CI)
FK 888 1-Methylindole-3-carboxaldehyde Gramine
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N2-[(4R)-4-hydroxyl-1-(1-methyl-1H-indol-3-yl)carbonyl-L-prolyl]-N-methyl-N-phenylmethyl-3-(2-naphthyl)-L-alaninamide hydrate FK 888 L-Alaninamide, (4R)-4-hydroxy-1-((1-methyl-1H-indol-3-yl)carbonyl)-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)- L-Alaninamide, trans-4-hydroxy-1-((1-methyl-1H-indol-3-yl)carbonyl)-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)- N(2)-(4-Hydroxy-1-(1-methyl-1H-indol-3-yl)carbonyl-L-prolyl)-N-methyl-N-phenylmethyl-3-(2-naphthyl)-L-alaninamide (4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide (4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide hydrate FK888 hydrate 138449-07-7