N,N-Diethyl-m-toluamide
- CAS No.
- 134-62-3
- Chemical Name:
- N,N-Diethyl-m-toluamide
- Synonyms
- DEET;DET;DIETHYLTOLUAMIDE;N,N-DIETHYL-3-METHYLBENZAMIDE;muscol;Detamide;DEET (N,N-DIETHYL-M-TOLUAMIDE);mgk;Off;m-DETA
- CBNumber:
- CB8853064
- Molecular Formula:
- C12H17NO
- Molecular Weight:
- 191.27
- MOL File:
- 134-62-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/24 22:20:23
| Melting point | -45 °C |
|---|---|
| Boiling point | 111 °C1 mm Hg |
| Density | 0.998 g/mL at 20 °C(lit.) |
| vapor density | 6.7 (vs air) |
| vapor pressure | <0.01 mm Hg ( 25 °C) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | room temp |
| solubility | DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| pka | -1.37±0.70(Predicted) |
| form | Liquid |
| color | Clear |
| Specific Gravity | 0.996 |
| Odor | mild bland odor |
| Water Solubility | NEGLIGIBLE |
| Merck | 14,2856 |
| BRN | 2046711 |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents, strong acids, strong bases. Hydrolyzes slowly in water. |
| InChIKey | CXVBTGKUSLNJQZ-UHFFFAOYSA-N |
| CAS DataBase Reference | 134-62-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Diethyltoluamide(134-62-3) |
| EPA Substance Registry System | N,N-Diethyl-m-toluamide (134-62-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H412 | |||||||||
| Precautionary statements | P264-P270-P273-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/38-52/53 | |||||||||
| Safety Statements | 61 | |||||||||
| RIDADR | 2810 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | XS3675000 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29242995 | |||||||||
| Toxicity | LD50 orally in male rats (ml/kg): 2.43; in female rats: 1.78; dermally in rabbits: 3.18; LC50 by inhalation in rats (mg/l): 5.95 (U.S. EPA) | |||||||||
| NFPA 704 |
|
N,N-Diethyl-m-toluamide price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D100951 | N,N-Diethyl-3-methylbenzamide 97% | 134-62-3 | 100G | ₹2587.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D100951 | N,N-Diethyl-3-methylbenzamide 97% | 134-62-3 | 500G | ₹3712.98 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR3304 | Diethyltoluamide certified reference material, pharmaceutical secondary standard | 134-62-3 | 3G | ₹15490.58 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D100951 | N,N-Diethyl-3-methylbenzamide 97% | 134-62-3 | 2KG | ₹10446.13 | 2022-06-14 | Buy |
| Sigma-Aldrich | 36542 | DEET PESTANAL?, analytical standard | 134-62-3 | 250MG | ₹4026.9 | 2022-06-14 | Buy |
N,N-Diethyl-m-toluamide Chemical Properties,Uses,Production
Description
DEET was first developed and patented by the US Army in 1946. It was approved for general public use by the US Environmental Protection Agency (EPA) in 1957 and was reregistered in 1998. It has been estimated that more than 1.8 million kg (～4 million pounds) of DEET are used in the United States every year in more than 225 registered products. DEET is often sold and used in lotions or sprays with concentrations up to 100%. However, the Center for Disease Control recommends only 30–50% DEET to reduce the incidence of vector-borne disease transmission. Registered products must contain at least 95% of the meta-isomer, but small amounts of the more toxic ortho-isomer and the less toxic para-isomer are permitted.
Chemical Properties
Colorless to Amberlike Liquid
History
Formulations registered for direct human application contain from 4% to 100% DEET. DEET was developed as a joint effort by the Department of Defense and U.S. Department of Agriculture (USDA). After examining hundreds of compounds for their repellent capabilities in the 1940s, DEET was selected and patented by the U.S. Army in 1946.the USDA did not announce DEET’s discovery until 1954, and it was registered for public use in 1957. DEET is prepared from m-toluoyl chloride and diethylamine in benzene or ether.
Indications
DEET is an organic liquid that is an excellent mosquito repellent; stronger
preparations of DEET are also effective against stable flies, although little protection
is provided against ticks. Commercial preparations are available in aerosol,
cream, or lotion form and vary in concentration from 6% to 100%. Because
DEET is absorbed into the bloodstream, it should be applied sparingly. Lesser
concentrations of DEET should be used whenever possible, with additional applications
to the skin if needed. Reports of a toxic encephalopathy and brief
seizures have been documented in children after overzealous use. Less serious
neurologic side effects include confusion, irritability, and insomnia. Contact dermatitis
has been observed with preparations containing higher concentrations of
DEET.
Use preparations with <20% DEET in children. Avoid mucous membranes,
broken skin, and hands of children, because they are often in contact with the
mouth. Spray clothing instead of skin whenever possible, but avoid contact
with rayon, acetate, or spandex, because these materials may be damaged by
DEET.
Definition
ChEBI: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of m-toluic acid with the nitrogen of diethylamine. It is the most widely used insect repellent worldwide.
General Description
Clear colorless or faintly yellow slightly viscous liquid. Faint pleasant odor.
Air & Water Reactions
N,N-Diethyl-3-methylbenzamide is sensitive to prolonged exposure to moisture. Insoluble in water.
Reactivity Profile
N,N-Diethyl-3-methylbenzamide is incompatible with strong acids, strong bases and strong oxidizing agents. N,N-Diethyl-3-methylbenzamide hydrolyzes slowly in the presence of water. N,N-Diethyl-3-methylbenzamide has a solvent effect on most plastics, paints, and varnishes. N,N-Diethyl-3-methylbenzamide is also incompatible with rayon, acetate or dynel clothing.
Fire Hazard
N,N-Diethyl-3-methylbenzamide is combustible.
Safety Profile
Poison by intravenous route. Moderately toxic by ingestion and skin contact. Human systemic effects: coma, convulsions, dermatitis, mydriasis @upillary ddation), nausea or vomiting, stiffness. An eye and skin irritant. Experimental reproductive effects by skin contact. Mutation data reported. Can cause central nervous system disturbances. A pesticide. DEET is the active ingredient in most commercial insect repellents. When heated to decomposition it emits toxic fumes of NOx
Environmental Fate
Historically, it was thought that DEET worked via blocking of
insect olfactory receptors and that DEET masked the target to
the insect senses so the insect would not detect a food source.
Instead, however, recent evidence indicates that the odor of
DEET is what acts as the true repellent. A specific type of an
olfactory receptor neuron in the antennal sensilla of mosquitoes
was identified, and this neuron is activated by DEET. This
activity is responsible for the properties that give DEET its
repellent ability.
DEET is also toxic to the central nervous system(CNS). DEET
acts as an inhibitor to the enzyme acetylcholinesterase which is
required for the proper functioning of the human nervous
system, other vertebrates, and insects. The enzyme acetylcholinesterase
hydrolyzes acetylcholine, which is important to
muscle control. When this process is inhibited, acetylcholine
builds up in the synaptic cleft and causes neuromuscular paralysis
and death by asphyxiation.
N,N-Diethyl-m-toluamide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Alkyl Amines Chemicals Limited | +91-91-22-24930710 +91-9075727921 | Mumbai, India | 65 | 58 | Inquiry |
| Allchem Lifescience Pvt. Ltd | +919867655500 | Gujarat, India | 971 | 58 | Inquiry |
| LAURICE LABS | +91-9820672480 +91-9820672480 | Maharashtra, India | 40 | 58 | Inquiry |
| Dodhia Group | +91-9619867345 +91-9619867345 | Mumbai, India | 129 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Amantech Chemicals Private Limited | 07842515829 | Mumbai, India | 62 | 58 | Inquiry |
| Keshav Industries | 08048618682 | Gujarat, India | 3 | 58 | Inquiry |
Related articles
- N,N-Diethyl-3-methylbenzamide (DEET): Synthesis, Composition, Applications, and Storage Guidelines
- N,N-Diethyl-3-methylbenzamide, commonly known as DEET, is one of the most widely used active ingredients in insect repellents.
- May 23，2024
- Toxicity of DEET
- DEET was first developed and patented by the US Army in 1946. It was approved for general public use by the US Environmental P....
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