prenylamine
- CAS No.
- 390-64-7
- Chemical Name:
- prenylamine
- Synonyms
- B-436;Corpax;Elecor;Segontin;Carditin;Bismethin;SAN 13-194;Hostaginan;prenylamine;Sandoz 13-194
- CBNumber:
- CB8875291
- Molecular Formula:
- C24H27N
- Molecular Weight:
- 329.47788
- MOL File:
- 390-64-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:39
| Melting point | 36.5-37.5° |
|---|---|
| Boiling point | 457.06°C (rough estimate) |
| Density | 1.0703 (rough estimate) |
| refractive index | 1.9000 (estimate) |
| storage temp. | Refrigerator |
| solubility | Chloroform: slightly soluble; Methanol: slightly soluble |
| form | A solid |
| pka | pKa 8.74±0.02(40% EtOH,t =25) (Uncertain) |
| color | Light yellow to yellow |
| Water Solubility | 50mg/L(37 ºC) |
prenylamine Chemical Properties,Uses,Production
Description
Prenylamine is a calcium channel inhibitor. It inhibits the plasma membrane Ca2+ ATPase (PMCA) in isolated and purified pig cardiac sarcolemma. It binds to a hydrophobic site on calcium-bound calmodulin (CaM) with a Kd value of 0.5 μM and inhibits CaM-activated cAMP phosphodiesterase (PDE) activity when used at concentrations ranging from 10 to 50 μM, an effect that is negatively associated with the concentration of calmodulin. Prenylamine (30 μM) shortens action potential duration and decreases the amplitude of peak calcium currents in single guinea pig ventricular myocytes in the absence and presence of propranolol and phentolamine . Prenylamine (50 mg/kg) decreases epinephrine, serotonin, and dopamine levels in rat brain. It also decreases epinephrine levels in rat heart. It protects anesthetized rats from coronary artery occlusion-induced arrhythmia when administered at a dose of 0.5 mg/kg but increases mortality due to atrioventricular block leading to asystole when administered at a dose of 5 mg/kg.
Chemical Properties
Pale Yellow Oil
Uses
Vasodilator (coronary).
World Health Organization (WHO)
Prenylamine is a calcium-channel blocking agent which was introduced in 1960. It has been widely used for the prophylaxis of angina pectoris and long-term treatment of coronary heart disease. Concern about its propensity to induce dangerous cardiac dysrhythmias led the company to withdraw it from the market.
prenylamine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 | China | 18021 | 56 | Inquiry |
| Alfa Chemistry | 1-516-6625404 | United States | 9171 | 60 | Inquiry |
| Cayman Chemical Company | (800) 364-9897 | United States | 6618 | 81 | Inquiry |
| Shaanxi Xihua Chemical Industry Co., Ltd | 17691182729 13992773979 | China | 6820 | 58 | Inquiry |
| 3B Scientific Corporation | 847.281.9822 | United States | 6744 | 47 | Inquiry |
| 2A PharmaChem USA | (630) 737-0988 | United States | 6148 | 39 | Inquiry |
| Yick-Vic Chemicals & Pharmaceuticals (HK) Ltd | (852)2541 2772 | China | 6214 | 58 | Inquiry |
| Shanghai New Union Textra Import & Export Co., Ltd | +861-348-227-9455 | China | 2752 | 60 | Inquiry |
| CHEMICAL LAND21 | 82- 2 -783 - 8063 | South Korea | 6315 | 74 | Inquiry |