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Propanolol

Propanolol Structure
CAS No.
525-66-6
Chemical Name:
Propanolol
Synonyms
PROPANALOL;Avlocardyl;rac-Propanolol;1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol;Reducor;Betalong;Avlocanol;208-378-0;Propanolol;Euprovasin
CBNumber:
CB0875381
Molecular Formula:
C16H21NO2
Molecular Weight:
259.34
MOL File:
525-66-6.mol
Modify Date:
2024/6/11 18:14:38

Propanolol Properties

Melting point 163-164 °C
Boiling point 402.6°C (rough estimate)
Density 1.0280 (rough estimate)
refractive index 1.5500 (estimate)
storage temp. -20°C Freezer, Under inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 13.84±0.20(Predicted)
color White to Off-White
Water Solubility 80.99mg/L(25 ºC)
CAS DataBase Reference 525-66-6
NIST Chemistry Reference Propranolol(525-66-6)
EPA Substance Registry System 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)- (525-66-6)

Propanolol Chemical Properties,Uses,Production

Description

Propranolol was responsible for sensitisation of workers in drug synthesis. In one case, epichlorhydrin was used for the production of both propranolol and oxprenolol.

Chemical Properties

Colorless crystals.Soluble in water and alcohol; insoluble in benzene and ether.

Uses

Cardiac depressant (anti-arrhythmic); anti-adrenergic (β-receptor).

Definition

ChEBI: A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.

Hazard

Highly toxic.

Contact allergens

Propranolol is a beta-blocking agent that was responsible for the sensitization of workers in drug synthesis. In one case, epichlorhydrin was used for the production of drugs propranolol and oxprenolol. Crossreactivity is expected between beta-blockers.

Propanolol Preparation Products And Raw materials

Raw materials

Preparation Products

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1-isopropylamino-3-(1-naphthyloxy)propan-2-ol Propanolol 1-[Isopropylamino]-3-[1-naphthyloxy]-2-propanol 2-Propanol, 1-(1-methylethyl)amino-3-(1-naphthalenyloxy)- 1-(1-Naphthyloxy)-3-(isopropylamino)-2-propanol 2-Propanol, 1-(isopropylamino)-3-(1-naphthyloxy)- (7CI, 8CI) 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)- (9CI) Betalong b-Propranolol Euprovasin Proprasylyt Racemic propranolol Reducor Proprasylyte 2-PROPANOL,1-(ISOPROPYLAMINO)-3-(1-NAPHTHYLOXY)- 1-Isopropylamino-3-(naphthalen-1-yloxy)-propan-2-ol Propranolol Base 1-Propanolol 1-(Isopropylamino)-3-(1-naphtyloxy)-2-propanol 1-Isopropylamino-3-(1-naphtyloxy)-2-propanol Avlocanol 208-378-0 Propanolol USP/EP/BP PropranololQ: What is Propranolol Q: What is the CAS Number of Propranolol Q: What is the storage condition of Propranolol Q: What are the applications of Propranolol Propranolol for system suitability (Y0002135)Q: What is Propranolol for system suitability (Y0002135) Q: What is the CAS Number of Propranolol for system suitability (Y0002135) PROPANALOL Avlocardyl rac-Propanolol 1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol Compound 525-66-6 beta-Propranolol 525-66-6