1-(2,6-Dimethylphenoxy)-2-propanamine
- CAS No.
- 31828-71-4
- Chemical Name:
- 1-(2,6-Dimethylphenoxy)-2-propanamine
- Synonyms
- Mexiletine;C07220;MEXILETIN;Mexilitine;Mexiletene;Mexilitine R;dl-Mexiletine;(RS)-Mexiletine;Mexiletine - API;1-Methyl-2-(2,6-xylyloxy)ethylamine
- CBNumber:
- CB9497353
- Molecular Formula:
- C11H17NO
- Molecular Weight:
- 179.26
- MOL File:
- 31828-71-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/19 15:37:50
| Melting point | 203-205 °C |
|---|---|
| Boiling point | 271.5±28.0 °C(Predicted) |
| Density | 0.979±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | ethanol: 50 mg/mL |
| pka | pKa 9.14± 0.01(H2O,t =25±0.2,I=0.01(NaCl))(Approximate) |
| form | powder |
| color | white |
| BCS Class | 1 |
| CAS DataBase Reference | 31828-71-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Mexiletine(31828-71-4) |
1-(2,6-Dimethylphenoxy)-2-propanamine Chemical Properties,Uses,Production
Uses
Cardiac depressant (anti-arrhythmic).
Definition
ChEBI: An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
Clinical Use
Mexiletine (Mexitil) is an antiarrhythmic agent with
pharmacological and antiarrhythmic properties similar
to those of lidocaine and tocainide. Like tocainide,mexiletine
is available for oral administration.
Mexiletine is useful as an antiarrhythmic agent in the
management of patients with either acute or chronic
ventricular arrhythmias.While it is not at present an indication
for use, there is interest in using mexiletine to
treat the congenital long QT syndrome when an abnormality
in the SCN5A gene (LQTS 3) has been found.
Side effects
A very narrow therapeutic window limits mexiletine use. The first signs of toxicity manifest as fine tremor of the hands, followed by dizziness and blurred vision. Hypotension, sinus bradycardia, and widening of the QRS complex have been noted as the most common unwanted cardiovascular effects of IV mexiletine. The side effects of oral maintenance therapy include reversible upper gastrointestinal distress, tremor, lightheadedness, and coordination difficulties. These effects generally are not serious and can be reduced by downward dose adjustment or administering the drug with meals. Cardiovascular adverse effects, which are less common, include palpitations, chest pain, and angina or anginalike pain.
Drug interactions
An upward adjustment in dose may be required when mexiletine is administered with phenytoin or rifampin, since these drugs stimulate the hepatic metabolism of mexiletine, reducing its plasma concentration.
Precautions
Mexiletine is contraindicated in the presence of cardiogenic shock or preexisting second- or third-degree heart block in the absence of a cardiac pacemaker. Caution must be exercised in administration of the drug to patients with sinus node dysfunction or disturbances of intraventricular conduction.
1-(2,6-Dimethylphenoxy)-2-propanamine Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLP Pharma Standards | +91 9866074638 | Hyderabad, India | 1644 | 58 | Inquiry |
| Cohance Lifesciences (Previously RA Chem Pharma Ltd) | +91-4044758595 +91-4044758595 | Telangana, India | 47 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | China | 2989 | 55 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | China | 9077 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 26415 | 58 | Inquiry |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | China | 15395 | 58 | Inquiry |
31828-71-4(1-(2,6-Dimethylphenoxy)-2-propanamine)Related Search:
1of4
chevron_right