Propafenone Hydrochloride
- CAS No.
- 34183-22-7
- Chemical Name:
- Propafenone Hydrochloride
- Synonyms
- PROPAFENONE HCL;Pronon;Rythmol;rytmonorm;SA-79 (hydrochloride);1-Propanone, 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-, hydrochloride (9CI);sa79;wz884;Ropaful;Sobiral
- CBNumber:
- CB1311105
- Molecular Formula:
- C21H28ClNO3
- Molecular Weight:
- 377.9
- MOL File:
- 34183-22-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/11 15:28:25
| Melting point | 165-1670C |
|---|---|
| storage temp. | 2-8°C |
| solubility | Slightly soluble in cold water, soluble in methanol and in hot water, practically insoluble in ethanol (96 per cent). |
| form | Solid |
| color | White to Off-White |
| λmax | 303nm(MeOH)(lit.) |
| Merck | 14,7794 |
| CAS DataBase Reference | 34183-22-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | T,Xn | |||||||||
| Risk Statements | 46-22 | |||||||||
| Safety Statements | 53-36/37/39-45 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UH2833000 | |||||||||
| HS Code | 2922504500 | |||||||||
| Toxicity | LD50 in rats (mg/kg): 18.8 i.v.; 700 orally (Hapke, Prigge) | |||||||||
| NFPA 704 |
|
Propafenone Hydrochloride price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | P4670 | Propafenone hydrochloride | 34183-22-7 | 5G | ₹13693.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P-148 | Propafenone hydrochloride solution 1?mg/mL in methanol ((as free base)), certified reference material, ampule of 1?mL, Cerilliant? | 34183-22-7 | 1ML | ₹9403.1 | 2022-06-14 | Buy |
| TCI Chemicals (India) | P2301 | Propafenone Hydrochloride | 34183-22-7 | 1G | ₹6400 | 2022-05-26 | Buy |
Propafenone Hydrochloride Chemical Properties,Uses,Production
Description
Propafenone hydrochloride is a class I anti-arrhythmic agent with basic local anaesthetic and membrane-stabilizing properties. Some P-adrenergic blocking action has also been described. Propafenone decreases the depolarization velocity and slows conduction in the His-Purkinje system with resultant increase in the PR interval and the QRS complex. Propafenone is used in the treatment of paroxysmal supraventricular tachycardias and ventricular arrhythmias.
Propafenone should not be used in uncontrolled cardiac failure, severe obstructive pulmonary disease or marked hypotension. Propafenone may worsen myasthenia gravis.
Chemical Properties
White Solid
Uses
Propafenone hydrochloride is a class IC antiarrhythmic agent used for the management of severe ventricular and supraventricular arrhythmias. It has beta-blocking and weak calcium channel blocking properties, as well as some negative inotropic activity. Propafenone is in a class of medications called antiarrhythmics. It works by acting on the heart muscle to improve the heart's rhythm.
Uses
Sodium channel blocker. Antiarrhythmic (class IC)
Definition
ChEBI: Propafenone hydrochloride is a hydrochloride that is the monohydrochloride salt of propafenone. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used in the management of supraventricular and ventricular arrhythmias. It has a role as an anti-arrhythmia drug. It contains a propafenone(1+).
Pharmacokinetics
Propafenone hydrochloride (Rythmol(R)) is similar in action to flecainide. It reduces the fast inward sodium current in Purkinje fibres and to a lesser extent in myocardial fibres. Unlike other class l drugs, propafenone has mild B-blocking effects. This may contribute to its overall effects on the conduction system. lt is also believed to have calcium channel-blocking effects, which may contribute to its mild negative inotropic effects.
Propafenone Hydrochloride Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Trimax bio sciences private ltd | +91-8532299988 +91-8532299988 | Karnataka, India | 36 | 58 | Inquiry |
| Athos Chemicals | 91-9998858909 | Gujarat, India | 315 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Oceanic Pharmachem Pvt., Ltd. (OPPL) | 91-22-42128600 | Maharashtra, India | 947 | 58 | Inquiry |
| Sign Pharma Trade Services Pvt., Ltd.(SPTS) | 91-22-23481235 | Mumbai, India | 160 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Pharmaffiliates Analytics & Synthetics (P) Ltd. | 91-172-5066494 | Haryana, India | 631 | 58 | Inquiry |
| Orbit Lifescience Pvt., Ltd. | 91-22-61113200 | Mumbai, India | 206 | 58 | Inquiry |
| Ayon PharmaChem | 91-22-28638348 | Maharashtra, India | 303 | 58 | Inquiry |