2'-Hydroxychalcone
- CAS No.
- 1214-47-7
- Chemical Name:
- 2'-Hydroxychalcone
- Synonyms
- 2-HYDROXYCHALC;O-CINNAMOYLPHENOL;6'-Hydroxychalcone;2'-HYDROXYCHALCONE;2'-hydroxychalcone;HYDROXYCHALCONE, 2'-;2'-HYDROXYCHALCONE 98%;2-HYDROXYBENZALACETOPHENONE;2-Hydroxyphenylstyryl ketone;2'-HYDROXYCHALCONE 1214-47-7
- CBNumber:
- CB3771305
- Molecular Formula:
- C15H12O2
- Molecular Weight:
- 224.25
- MOL File:
- 1214-47-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:06
| Melting point | 86-88 °C(lit.) |
|---|---|
| Boiling point | 396.6±42.0 °C(Predicted) |
| Density | 1.191±0.06 g/cm3 (20 ºC 760 Torr) |
| storage temp. | Store below +30°C. |
| pka | 7.77±0.30(Predicted) |
| form | Solid |
| color | Light yellow to yellow |
| BRN | 976324 |
| LogP | 4.000 (est) |
| CAS DataBase Reference | 1214-47-7(CAS DataBase Reference) |
| EPA Substance Registry System | 2-Propen-1-one, 1-(2-hydroxyphenyl)-3-phenyl- (1214-47-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UD5579400 | |||||||||
| F | 8 | |||||||||
| Autoignition Temperature | 280 °C | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29145090 | |||||||||
| Toxicity | mammal (species unspecified),LD50,unreported,620mg/kg (620mg/kg),Pharmaceutical Chemistry Journal Vol. 20, Pg. 406, 1986. | |||||||||
| NFPA 704 |
|
2'-Hydroxychalcone price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 8.14776 | 1-(2-Hydroxyphenyl)-3-phenyl-2-propenone for synthesis | 1214-47-7 | 25G | ₹5510.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.14776 | 1-(2-Hydroxyphenyl)-3-phenyl-2-propenone for synthesis | 1214-47-7 | 100G | ₹10770 | 2022-06-14 | Buy |
| ALFA India | ALF-L13937-14 | 2'-Hydroxychalcone, 95% | 1214-47-7 | 25g | ₹5102 | 2022-05-26 | Buy |
| ALFA India | ALF-L13937-06 | 2'-Hydroxychalcone, 95% | 1214-47-7 | 5g | ₹1704 | 2022-05-26 | Buy |
2'-Hydroxychalcone Chemical Properties,Uses,Production
Chemical Properties
Yellow needle-like crystals (ethanol). Melting point 88-89°C.
Uses
2'-Hydroxychalcone can be used as intermediates in drug synthesis, such as the preparation of flavonol compounds. Flavonols are widely distributed in nature as secondary metabolites in living organisms, and they have a wide variety of physiological activities, mainly in the cardiovascular system, antiviral, anti-inflammatory and antitumor effects.
Definition
ChEBI: 2'-hydroxychalcone is a member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 2'. It has a role as an anti-inflammatory agent. It is a member of phenols and a member of chalcones. It derives from a trans-chalcone.
Preparation
Synthesis of 2'-hydroxychalcone: add 30 ml of 20% (V/V) ethanol and (11.06 mmol) sodium hydroxide in a 50 mL single mouth flask, stir for 0.5 h at room temperature and then add substituted 2-Hydroxyacetophenone (1.66 mmol) and benzaldehyde (1.66 mmol), stir for 18 h at room temperature, TLC monitoring until the new point produces raw material point no longer changes, stop the reaction Then the reaction was poured into water, stirred while adjusting the pH value to acidic with 6 mol/L hydrochloric acid, the reaction was filtered, the filter cake was obtained, rinsed twice with pure water, and 2'-hydroxychalcone was obtained by silica gel column chromatography [V(petroleum ether):V(ethyl acetate) = 5:1] in 85% yield.
2'-Hydroxychalcone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| chromsynth pvt ltd | +919704220374 | Hyderabad, India | 244 | 58 | Inquiry |
| Biosyn Research Chemicals | +91-91-9346022300 +91-9346022300 | Telangana, India | 465 | 58 | Inquiry |
| Hyderabad | +91-9676447615 +91-9676447615 | Telangana, India | 192 | 58 | Inquiry |
| SVH BIOSCIENCES | +91-6303499280 +91-6303499280 | Hyderabad, India | 478 | 58 | Inquiry |
| AVIGYABIOSCIENCES PRIVATE LIMITED | +91-9849533087 +91-9849533087 | Telangana, India | 156 | 58 | Inquiry |
| Trimax bio sciences private ltd | +91-8532299988 +91-8532299988 | Karnataka, India | 36 | 58 | Inquiry |
| Dr Chindepalli | 91-7036227677 | Hyderabad, India | 486 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Reax Chemicals | 08048372701Ext 416 | Hyderabad, India | 4223 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| chromsynth pvt ltd | 58 |
| Biosyn Research Chemicals | 58 |
| Hyderabad | 58 |
| SVH BIOSCIENCES | 58 |
| AVIGYABIOSCIENCES PRIVATE LIMITED | 58 |
| Trimax bio sciences private ltd | 58 |
| Dr Chindepalli | 58 |
| Clearsynth Labs | 58 |
| Reax Chemicals | 58 |
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