Galangin
- CAS No.
- 548-83-4
- Chemical Name:
- Galangin
- Synonyms
- Galengin;GALANGIN;NORIZALPININ;GALANGIN hplc;Galangin (6CI);Galangin, >=98%;Galangin Standard;GALANGIN WITH HPLC;7-Trihydroxyflavone;3,5,7-trihydroxy-flavon
- CBNumber:
- CB8413460
- Molecular Formula:
- C15H10O5
- Molecular Weight:
- 270.24
- MOL File:
- 548-83-4.mol
- Modify Date:
- 2023/8/23 18:01:39
| Melting point | 214-215 °C(lit.) |
|---|---|
| Boiling point | 333.35°C (rough estimate) |
| Density | 1.2319 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | room temp |
| solubility | Acetone (Slightly), Ethyl Acetate (Slightly) |
| form | Solid |
| pka | 6.32±0.40(Predicted) |
| color | Light Yellow to Yellow |
| Merck | 14,4339 |
| BRN | 272179 |
| InChIKey | VCCRNZQBSJXYJD-UHFFFAOYSA-N |
| LogP | 3.322 (est) |
| CAS DataBase Reference | 548-83-4(CAS DataBase Reference) |
Galangin price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 282200 | Galangin autophagy inducing flavonoid | 548-83-4 | 25MG | ₹7837.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 282200 | Galangin autophagy inducing flavonoid | 548-83-4 | 25MG | ₹7837.3 | 2022-06-14 | Buy |
| Sigma-Aldrich | 282200 | Galangin autophagy inducing flavonoid | 548-83-4 | 100MG | ₹18792.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 282200 | Galangin autophagy inducing flavonoid | 548-83-4 | 100MG | ₹18792.2 | 2022-06-14 | Buy |
| ALFA India | ALF-L14223-MC | 3,5,7-Trihydroxyflavone, 97% | 548-83-4 | 100mg | ₹20769 | 2022-05-26 | Buy |
Galangin Chemical Properties,Uses,Production
Description
Galangin is a flavonoid naturally found in herbs used in traditional medicine. Like many flavonoids, it has potent antioxidant properties. It also has anti-inflammatory actions related to suppression of signaling through NF-κB in mice. Galangin acts as an antagonist of the aryl hydrocarbon receptor, inducing apoptosis in cancer cells. It also inhibits cytochrome P450 isoform 1A1 with an IC50 value of less than 1 μM.
Chemical Properties
Yellow powder
Definition
ChEBI: A 7-hydroxyflavonol with additional hydroxy groups at positions 3 and 5 respectively.
General Description
Galangin is a flavonoid isolated from members of the Zingiberaceae family, which are mainly used for herbal medicines.
Anticancer Research
Galangin is a flavonol that is derived from Alpinia officinarum, a plant from the gingerfamily, grown in Southeast Asia. The extract from the rhizome suppresses cellproliferation of hepatocellular carcinoma cells (Su et al. 2013). ER stress is inducedby galangin as is evident by rise in concentration of cytosolic Ca2+ and other UPRtarget genes like CHOP, GRP 78 and GRP 94. The ER is a major storage site forintracellular calcium. Normal functioning of ER chaperones is disrupted by calciumexhaustion in ER which produces ER stress and hence activation of UPR (Hotamisligil2010; Mekahli et al. 2011). CHOP and 4-polybutyric acid siRNA, well-known ERstress inhibitor, substantially blocked stress induced by galangin in the HCC cell line.To sum up, ER stress is upregulated by galangin, inhibiting cancer cell proliferation,and galangin can prove to be an effective anticancer agent (Su et al. 2013).
Galangin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SynthoCascade Research Laboratories | +91-9440962500 +91-9440962500 | Telangana, India | 284 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21669 | 55 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29897 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| SynthoCascade Research Laboratories | 58 |
| CHEMSWORTH | 30 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Alfa Aesar | 58 |
| SynZeal Research Pvt Ltd | 58 |
| Capot Chemical Co.,Ltd. | 60 |
| Henan Tianfu Chemical Co.,Ltd. | 55 |
| career henan chemical co | 58 |