Diosmin | 520-27-4

Diosmin Properties

Melting point	277-278°C
Boiling point	926.8±65.0 °C(Predicted)
Density	1.68±0.1 g/cm3(Predicted)
vapor pressure	0Pa at 20℃
storage temp.	Sealed in dry,2-8°C
solubility	Practically insoluble in water, soluble in dimethyl sulfoxide, practically insoluble in alcohol. It dissolves in dilute solutions of alkali hydroxides.
form	Solid
pka	6.10±0.40(Predicted)
color	Pale Beige to Brown
Water Solubility	Soluble in DMSO (50 mg/ml), water (122 mg/ml at 25°C), and ethanol (<1 mg/ml at 25°C).
λmax	345nm(EtOH)(lit.)
Merck	14,3297
InChIKey	GZSOSUNBTXMUFQ-YFAPSIMESA-N
LogP	0.14 at 20℃
CAS DataBase Reference	520-27-4(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H412
Precautionary statements	P501-P273-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-36/37-24/25
WGK Germany	3
HS Code	29381000

Diosmin price More Price(4)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	PHR2799	Diosmin certified reference material, pharmaceutical secondary standard	520-27-4	500MG	₹15490.58	2022-06-14	Buy
Sigma-Aldrich(India)	61386	Diosmin analytical standard	520-27-4	50MG	₹25081.53	2022-06-14	Buy
TCI Chemicals (India)	D3908	Diosmin	520-27-4	5G	₹3200	2022-05-26	Buy
TCI Chemicals (India)	D3908	Diosmin	520-27-4	25G	₹8100	2022-05-26	Buy

Product number	Packaging	Price	Buy
PHR2799	500MG	₹15490.58	Buy
61386	50MG	₹25081.53	Buy
D3908	5G	₹3200	Buy
D3908	25G	₹8100	Buy

Diosmin Chemical Properties,Uses,Production

Description

Diosmin was separated from the root of Scrophularia nodosa L. in 1925. The root of Scrophularia nodosa L. has the function of nourishing, reducing fever, relieving internal heat, and detoxicating. It was firstly recorded in the Shen Nong’s Classic of Materia Medica, as a class of middle-grade drug and is currently recorded in the Ch.P 2015, Volume I. The natural resource was abundant in China, mainly provided from Zhejiang, Sichuan, Hubei, Anhui, and Jiangsu provinces. In the clinical practice, Scrophularia nodosa L. was employed to eliminate pathogenic heat from the blood. In the clinical indication, diosmin was mainly applied to treat fever, polydipsia, maculitis, gingivitis, amygdalitis, laryngopharyngitis, acute lymphadenitis, etc. It also has the biological function of antiplatelet aggregation and antitumor. The chemical components include iridoids, phenylpropanoid glycoside, flavonoids, and fatty acids.

Chemical Properties

Diosmin is a natural flavonoid mainly present in the peel of some citrus fruits, such as oranges and lemons. Flavonoids are anti-inflammatory plant compounds that protect your body from free radicals and other unstable molecules. The most prevalent uses for Diosmin include hemorrhoids and leg sores caused by poor blood flow. Diosmin was first found in 1925 in the wort plant and has since been used as a natural treatment for hemorrhoids, varicose veins, venous insufficiency, leg ulcers, and other circulatory issues.

Physical properties

Appearance: Grayish yellow or light yellow hygroscopic powder. Solubility: Practically insoluble in water, soluble in dimethyl sulfoxide, practically insoluble in alcohol. It dissolves in dilute solutions of alkali hydroxides. Melting point: 277–278°C.

History

Diosmin was firstly introduced as a medicine in 1969. It was launched in France in 1987 with the product name “Alvenor.” As the protecting agent for blood vessel and therapeutic agent for chronic venous disease, diosmin has been used for over 30?years in Europe
Diosmin is a typical flavonoid. It could be prepared from natural resources or semisynthesized from the natural product hesperidin by dehydrogenation reaction.

Uses

Diosmin is an agonist of the aryl hydrocarbon receptor (AhR) and exhibits anti-proliferative and anti-inflammatory. It is used in the treatment of venous disease, i.e., chronic venous insufficiency (CVI) and hemorrhoidal disease (HD). Diosmin also reduces capillary hyperpermeability and expression of endothelial adhesion molecules (ICAM1, VCAM1). It effectively inhibits the P-glycoprotein (Pgp)-mediated efflux in cells.

Indications

The clinical indications of diosmin are those symptoms related to venous-lymphatic dysfunction such as leg heaviness, pains, soreness, and swelling in the morning. Besides, the symptoms related to acute hemorrhoids could also be treated with diosmin.

Definition

ChEBI: Diosmin is a disaccharide derivative that consists of diosmetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. It has a role as an antioxidant and an anti-inflammatory agent. It is a glycosyloxyflavone, a rutinoside, a disaccharide derivative, a monomethoxyflavone and a dihydroxyflavanone. It derives from a diosmetin.

Pharmacology

Diosmin is a micronized, purified, flavonoid-structure drug. It is helpful for lymphatic return and stimulating microcirculation, treating hemorrhoids and venous dysfunction by increasing the venous tension.
1. Increasing the venous tension. Diosmin could strengthen the tensile force of the venous wall even under high temperature. Diosmin’s action in venous constriction is stronger than other drugs like rutin. Even under the acidic toxicity in the body, it could still raise the venous tension. Diosmin has special affinity to the venous other than the arterial system.
2. Improving the microcirculation. Diosmin could effectively reduce adhesion and migration of leukocyte and vascular endothelial cells. It could also release inflammatory substances such as histamine, bradykinin, alexin, leukotriene, prostaglandin, and surplus free radicals. Hence, the penetration of capillary blood vessel was reduced, and the tension was enhanced. Besides, diosmin could decrease blood viscosity, accelerate erythrocyte flow rate, and finally reduce the chances of microcirculatory stasis
3. Stimulating the lymphatic return. Diosmin could effectively increase the speed of lymphatic drainage and the lymphatic contraction, accelerating the circumfluence of interstitial fluid, improving lymphatic return, and relieving edema.

Clinical Use

Diosmin was mainly used to treat diseases like chronic venous dysfunction, haemorrhoids, lymphedema, phlebeurysm, etc.

Side effects

Diosmin can cause some side effects such as nausea, stomach pain, diarrhea, insomnia, dizziness, headache, drowsiness, skin redness and hives, muscle pain, blood problems, and altered heart rate.
There may be a few of minor gastrointestinal reactions and adverse reactions such as plant nerve function disorder, but generally mild and don't have to stop the drug.
Pregnant women and nursing mothers with hemorrhoids are safe to use this product.

Mode of action

1. Enhance the vein tension, even not exceptional under high temperature condition. It has a stronger effect causing the constriction of vein than other drugs such as rutin, still can enhance the tension of the vein when the body was acidosis. Diosmin has specific affinity for vein without affecting the arterial system.
2. Improve microcirculation. Diosmin can obviously reduce the white blood cells and vascular endothelial cell adhesion, migration, disintegrating the release of inflammatory substances, such as histamine, slow excitation peptide, complement, leukotriene, prostaglandins, and too many free radicals, reducing the permeability of capillaries and enhance its tension. Diosmin can lower blood viscosity, enhance the function of red blood cell velocity, thus reduce the microcirculation clogged.
3. Promote lymphatic circumfluence. Diosmin can increase the speed of lymphatic drainage.

Diosmin Preparation Products And Raw materials

Raw materials

Sodium hydroxide Acetic acid Hesperidin Acetic anhydride

Preparation Products

Diosmin Suppliers

Global( 635)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Sindhu Organics Pvt Ltd	+91-9833086472 +91-9820087786	Maharashtra, India	3	58	Inquiry
Bajaj Healthcare Ltd	+91-2266177400 +91-2266177400	Maharashtra, India	86	58	Inquiry
Penam Laboratories Ltd	+91-1145084500 +91-1145084500	New Delhi, India	13	58	Inquiry
Molsyns Research	+91-9586858886 +91-9586858886	Gujarat, India	418	58	Inquiry
AKASH PHARMA EXPORTS	+91-9388123451 +91-9846039283	Kerela, India	470	58	Inquiry
Anant Pharmaceuticals Pvt. ltd	+91 8550986868	Maharashtra, India	736	58	Inquiry
OCEAN TRADING CORPORATION	+91(22) 24921669	New Delhi, India	6211	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Festiva Pharma	08048372775Ext 728	Gujarat, India	238	58	Inquiry

Supplier	Advantage
Sindhu Organics Pvt Ltd	58
Bajaj Healthcare Ltd	58
Penam Laboratories Ltd	58
Molsyns Research	58
AKASH PHARMA EXPORTS	58
Anant Pharmaceuticals Pvt. ltd	58
OCEAN TRADING CORPORATION	58
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Festiva Pharma	58

Related Qustion

Q:Is diosmin the same as Daflon?
A:Diosmin is most widely used to treat blood vessel disorders, such as hemorrhoids and chronic venous insufficiency (CVI).
Jun 19，2024

Diosmin Spectrum

Diosmin(520-27-4)¹HNMR Diosmin(520-27-4)IR1 Diosmin(520-27-4)IR2

520-27-4(Diosmin)Related Search:

p-Anisidine Chrysin p-Anisaldehyde (Trifluoromethoxy)benzene 4-Methoxybenzylchloride

4-Methoxyphenylacetone 3-Methoxybenzaldehyde Anisole 4-N-PENTYLOXYBENZALDEHYDE 2',4',6'-Trihydroxyacetophenone monohydrate

Paeonol 5-HYDROXY-7-METHOXYFLAVONE 5,4'-DIHYDROXYFLAVONE 4-N-BUTOXYBENZALDEHYDE Triethylene glycol

4'-METHOXYFLAVONE Ethylene Glycol Dibutyl Ether Diosmin+Hesperidin520-27-4+

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DIOSMETIN-7-RUTINOSIDE DIOSMIN BAROSMIN Diovenor BAROSMIN hplc 3',5-Dihydroxy-4'-methoxy-7-(6-O-α-L-rhamnopyranosyl-β-D-glucopyranosyloxy)flavone 7-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2-(3-hydroxy-4-methoxyphenyl)-5-hydroxy-4H-1-benzopyran-4-one 7-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one Diosmin+ Hesperidin DIOSMIN WITH HPLC 7-[[6-O-(6-Deoxy-a-L-mannopyranosyl)--D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one Venosmine Diosmin (300 mg) Barosmin 3',5,7-Trihydroxy-4'-methoxyflavone 7-Rutinoside DiosMin (3',5,7-Trihydroxy-4'-Methoxyflavone 7-rutinoside) Diosven Dioven FlebosMil Flebosten 4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)- Diosmin, >=95% Diosmin+Hesperidin 90:10 3',5,7-TRIHYDROXY-4'-METHOXYFLAVONE 7-RUTINOSIDE 3,5,7-TRIHYDROXY-4-METHOXYFLAVONE 7-RUTINOSIDE Diosmine EP4 Buchu resin Diosmil Diosmine/Hesperidine 90:10 Rubber powder Diosmin for system suitability CRS Diosmin> 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one Diosmin USP/EP/BP Dominion 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one Diosmin D3Q: What is Diosmin D3 Q: What is the CAS Number of Diosmin D3 Q: What are the applications of Diosmin D3 Diosmin for system suitability (Y0000095) DiosminQ: What is Diosmin Q: What is the CAS Number of Diosmin Q: What is the storage condition of Diosmin Q: What are the applications of Diosmin Diosmin (1213318) DIOSMETIN-7-O-RUTINOSIDE DIOSIMIN Hesperedin DIOSMINE Daflon SiF6 Diosmin CRS iosmin/Diosimin iosmin COc5ccc(c4cc(=O)c3c(O)cc(O[C@@H]2O[C@H](CO[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O)[C@@H](O)[C@H](O)[C@H]2O)cc3o4)cc5O Diosmin (7CI, 8CI) 3',5-Dihydroxy-4'-methoxy-7-(6-O-α-L-rhamnopyranosyl-β-D-glucopyranosyloxy)flavone Diosmin DIOSMETIN-7-O-RUTINOSIDE Diosmin:Hesperidn 4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)- Diosmin, ≥ 85.0% Diosmin Reference Standard Diosmin Crude 520-27-4