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ChemicalBook > Product Catalog >Biochemical Engineering >Plant extracts >7,8-Dihydroxyflavone

7,8-Dihydroxyflavone

7,8-Dihydroxyflavone Structure
CAS No.
38183-03-8
Chemical Name:
7,8-Dihydroxyflavone
Synonyms
7,8-DHF;7,8-Dihydroxyflavone hydrate;7,8-dihydroxy-2-phenyl-4-benzopyrone;7,8-DIHYDROXY;7,8-Di-OH flavone;8-Dihydroxyflavone;TIMTEC-BB SBB000930;7,8-DIHYDROXYFLAVONE;DIHYDROXYFLAVONE, 7,8-;7,8-dihydroxy Flavones
CBNumber:
CB5478886
Molecular Formula:
C15H10O4
Molecular Weight:
254.24
MOL File:
38183-03-8.mol
Modify Date:
2024/6/18 13:26:42
Request For Quotation

7,8-Dihydroxyflavone Properties

Melting point 243-246°C
Boiling point 494.4±45.0 °C(Predicted)
Density 1.443±0.06 g/cm3(Predicted)
FEMA 4830 | 7,8-DIHYDROXYFLAVONE
storage temp. Inert atmosphere,Room Temperature
solubility DMSO: soluble24mg/mL
form solid
pka 6.86±0.40(Predicted)
color Yellow or tan
Stability Stable for 1 year from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 week.
InChI InChI=1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H
InChIKey COCYGNDCWFKTMF-UHFFFAOYSA-N
SMILES C1(C2=CC=CC=C2)OC2=C(O)C(O)=CC=C2C(=O)C=1
LogP 2.760 (est)
CAS DataBase Reference 38183-03-8(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22
Safety Statements  24/25
WGK Germany  3
RTECS  DJ3004000
HS Code  2932990090
NFPA 704
1
0 0

7,8-Dihydroxyflavone price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) D5446 7,8-Dihydroxyflavone hydrate ≥98% (HPLC) 38183-03-8 10MG ₹8746.6 2022-06-14 Buy
Sigma-Aldrich(India) D5446 7,8-Dihydroxyflavone hydrate ≥98% (HPLC) 38183-03-8 50MG ₹34531.75 2022-06-14 Buy
Sigma-Aldrich(India) 5.06300 TrkB Agonist, 7,8-Dihydroxyflavone - CAS 38183-03-8 - Calbiochem 38183-03-8 100MG ₹24770.01 2022-06-14 Buy
TCI Chemicals (India) D1916 7,8-Dihydroxyflavone 38183-03-8 1G ₹4800 2022-05-26 Buy
TCI Chemicals (India) D1916 7,8-Dihydroxyflavone 38183-03-8 5G ₹15000 2022-05-26 Buy
Product number Packaging Price Buy
D5446 10MG ₹8746.6 Buy
D5446 50MG ₹34531.75 Buy
5.06300 100MG ₹24770.01 Buy
D1916 1G ₹4800 Buy
D1916 5G ₹15000 Buy

7,8-Dihydroxyflavone Chemical Properties,Uses,Production

Description

7,8-Dihydroxyflavone(7,8-DHF) is a naturally occurring flavone found in the tree Godmania aesculifolia. It is a selective tyrosine kinase receptor B(TrkB) agonist that has neurotrophic effects in various neurological diseases such as stroke and Parkinson's disease. 7,8-Dihydroxyflavone binds to the TrkB receptors in a similar way to BDNF, or brain derived neurotrophic factor. When the TrkB receptor is activated, neuroprotective and neurogenetive effects occur in neurons, which tend to affect the dendrites. Dendrites are what reach out from the neurons into the synapse to participate in signaling with other neurons. 7,8-DHF has been shown to promote the growth of these dendrites, and to help restore communication between neurons in animal models.

Chemical Properties

White crystalline powder or Yellow Solid, soluble in methanol, ethanol, DMSO and other organic solvents, from the dried root of Pulsatilla chinensis (Bge.) Regel.

Uses

7,8-Dihydroxyflavone is disubstituted flavone that acts as a small-molecule TrkB agonist. 7,8-Dihydroxyflavone has been shown to reverse memory deficits and BACE1 elevation in a mouse model of Alzheimer''s disease. 7,8-Dihydroxyflavone may also provide a therapeutic option in the treatment of other neorological disorders such as Rett syndrome and PTSD. It has recently been shown to counteract the inhibition of NMDA receptor caused by lead poisoning and confer protective effects in live rats.

Biological Activity

7,8-Dihydroxyflavone (7,8-DHF) is a monophenolic flavone with diverse effects. It acts as an agonist of the neurotrophic tyrosine kinase receptor TrkB (Kd = 320 nM), protecting neurons that express TrkB from apoptosis. 7,8-DHF is neuroprotective in an animal model of Parkinson’s disease. It supports emotional learning in mice and reverses memory deficits in a mouse model of Alzheimer’s disease. It also improves motor function and extends survival in an animal model of Huntington’s disease. 7,8-DHF inhibits the cytochrome P450 aromatase (IC50 = 10 μM) and, in this way, alters estrogen metabolism. It also has antioxidant action that increases intracellular glutathione synthesis and scavenges reactive oxygen species.

7,8-Dihydroxyflavone Preparation Products And Raw materials

Raw materials

4H-1-Benzopyran-4-one, 2-phenyl-7,8-bis(phenylmethoxy)- 4H-1-Benzopyran-4-one, 7,8-bis(benzoyloxy)-2-phenyl- Ethanone, 1-[2,3,4-tris(phenylmethoxy)phenyl]- Ethanone, 1-[2-hydroxy-3,4-bis(phenylmethoxy)phenyl]- 7,8-DIMETHOXYFLAVONE
2'-HYDROXY-3',4'-DIMETHOXYACETOPHENONE 2',3',4'-TRIHYDROXYACETOPHENONE 7-HYDROXYFLAVONE Pyrogallol Benzoic anhydride
Benzoyl chloride
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Preparation Products

7,8-Dihydroxyflavone Suppliers

Global( 292)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
GLR Innovations +91 9891111994 New Delhi, India 4542 58 Inquiry
OCIMUM LIFESCIENCES PVT LTD +91-9550445577 +91-9550445577 Hyderabad, India 52 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Biosyn Research Chemicals +91 9346022300/+91 9399339999 Telangana, India 1340 58 Inquiry
Evans Fine Chem 08048602255 Hyderabad, India 289 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
Wuhan Nutra Biotechnology Co.,Ltd +8617786394783 China 300 58 Inquiry
Wuhan senwayer century chemical Co.,Ltd +undefined-27-86652399 +undefined13627115097 China 888 58 Inquiry
Tianjin Kilo Pharmaceutical Sci-Tech Co., Ltd +86-02223869539 +86-15560057295 China 27 58 Inquiry
Supplier Advantage
GLR Innovations 58
OCIMUM LIFESCIENCES PVT LTD 58
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
Biosyn Research Chemicals 58
Evans Fine Chem 58
TCI Chemicals (India) Pvt. Ltd. 58
Wuhan Nutra Biotechnology Co.,Ltd 58
Wuhan senwayer century chemical Co.,Ltd 58
Tianjin Kilo Pharmaceutical Sci-Tech Co., Ltd 58

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7,8-Dihydroxyflavone Spectrum

7,8-Dihydroxyflavone(38183-03-8)1HNMR

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7,8-DIHYDROXYFLAVONE DIHYDROXYFLAVONE, 7,8-(RG) 7,8-dihydroxy-2-phenyl-4h-1-benzopyran-4-on TIMTEC-BB SBB000930 DIHYDROXYFLAVONE, 7,8- 7,8-Dihydroxy-2-phenyl-4H-chroMen-4-one 4H-1-Benzopyran-4-one,7,8-dihydroxy-2-phenyl- 2-Phenyl-7,8-dihydroxy-4H-1-benzopyran-4-one 7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one 7,8-dihydroxy-2-phenyl-chromen-4-one 7,8-dihydroxy-2-phenylchromen-4-one 7,8-dihydroxy-2-phenyl-chromone 6,7-dihydroxy-2-phenyl-4H-chromen-4-one 7,8-DIHYDROXY 7,8-dihydroxy Flavones, 7,8-DHF 7,8-dihydroxy-2-phenyl-1-benzopyran-4-one 8-Dihydroxyflavone 7,8-DIHYDROXYFLAVONE 7,8-DIHYDROXYFLAVONE 7,8-dihydroxyflavone (7,8-DHF) 7,8-DihydroxyflavoneHydrate> 7,8-dihydroxy Flavones 7,8-Di-OH flavone Flavone,7,8-dihydroxy- (6CI) 7,8-dihydroxy-2-phenyl-4-benzopyrone 7,8-Dihydroxyflavone hydrate 7,8-DHF 2-(Dimethylamino)ethyl methacrylate 2867-47-2 Acibenzolar Acid Impurity 16 7,8-Dihydroxyflavone, ≥ 98.0% 38183-03-8 C15H10O4xH2O Flavonoids Inhibitors Biochemistry Flavonoids Di-substituted Flavones pharmaceutical BPC plant extract