Pramipexole dihydrochloride monohydrate
- CAS No.
- 191217-81-9
- Chemical Name:
- Pramipexole dihydrochloride monohydrate
- Synonyms
- Pramipexole dihydrochloride monohydrate;Mirapex;Pramipexole for system suitability CRS;Pra-API;Pramipexole;Unii-3D867np06j;Pramipexole powder;PPX dihydrochloride;Pramipexole HCl hydrate;Pramipexole monohydrate
- CBNumber:
- CB6969615
- Molecular Formula:
- C10H20ClN3OS
- Molecular Weight:
- 265.8
- MOL File:
- 191217-81-9.mol
- Modify Date:
- 2024/7/4 14:04:14
| Melting point | 290 °C(dec.) |
|---|---|
| storage temp. | 2-8°C |
| solubility | Freely soluble in water, soluble in methanol, sparingly soluble or slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. |
| form | Solid |
| color | White to Almost white |
| Merck | 14,7705 |
| BCS Class | 1 |
| InChI | InChI=1/C10H17N3S.ClH.H2O/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;/h7,12H,2-6H2,1H3,(H2,11,13);1H;1H2/t7-;;/s3 |
| InChIKey | ZTZQAWQFTIVKMU-DCFBZVEJNA-N |
| SMILES | NC1SC2C[C@@H](NCCC)CCC=2N=1.Cl.O |&1:5,r| |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H336 |
| Precautionary statements | P261-P264-P270-P271-P301+P312-P304+P340+P312 |
| WGK Germany | 3 |
| RTECS | DL3375000 |
| HS Code | 2934200000 |
Pramipexole dihydrochloride monohydrate price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR1598 | Pramipexole Dihydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 191217-81-9 | 500MG | ₹9103.83 | 2022-06-14 | Buy |
| TCI Chemicals (India) | P2073 | Pramipexole Dihydrochloride Monohydrate | 191217-81-9 | 100MG | ₹3700 | 2022-05-26 | Buy |
| TCI Chemicals (India) | P2073 | Pramipexole Dihydrochloride Monohydrate | 191217-81-9 | 1G | ₹10800 | 2022-05-26 | Buy |
Pramipexole dihydrochloride monohydrate Chemical Properties,Uses,Production
Description
Pramipexole dihydrochloride monohydrate is an activator of D2DR, D3DR and D4DR. Pramipexole has been found to have neuroprotective effects independent of its dopamine receptor agonism. It reduces mitochondrial reactive oxygen species (ROS) production and inhibits the activation of apoptotic pathways.
Chemical Properties
White or almost white, crystalline powder.
Uses
Pramipexole is a drug used to treat the symptoms of Parkinson's Disease (PD) and a antidepressant. It is a non-ergot dopamine agonist drug that is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement)
Definition
ChEBI: A hydrate that is the monohydrate of the dihydrochloride salt of pramiprexole.
General Description
Pramipexole Dihydrochloride is a non-ergot dopamine agonist widely used for the treatment of early and advanced Parkinson′s disease (PD). It is also used to treat restless legs syndrome.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Clinical Use
Parkinson’s disease
Symptomatic treatment of restless legs
Side effects
Dizziness, lightheadedness, or fainting, especially when standing up suddenly from a sitting/lying position.
drowsiness.
nausea.
seeing, hearing, or feeling things that are not there.
trouble sleeping.
twitching, twisting, or other unusual body movements.
unusual tiredness or weakness.
Pramipexole dihydrochloride monohydrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SNA HEALTHCARE PVT LTD | +91-8652842416 +91-8652842416 | Mumbai, India | 88 | 58 | Inquiry |
| Nosch Labs Pvt Ltd | +91-4048557474 +91-9948222287 | Hyderabad, India | 58 | 58 | Inquiry |
| Piramal Pharma Solutions | +919892735994 | Maharashtra, India | 48 | 58 | Inquiry |
| Apotex Pharmachem India Pvt Ltd | +91-8022891034 +91-8022891000 | Karnataka, India | 109 | 58 | Inquiry |
| Cipla Ltd | +912224826000 | Maharashtra, India | 133 | 58 | Inquiry |
| Alembic Pharmaceuticals Limited | +91-2652280880 +91-2652280550 | Gujarat, India | 115 | 58 | Inquiry |
| Swapnroop Drugs & Pharmaceuticals | +91 (240) 664-1875 | New Delhi, India | 91 | 50 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Apotex Pharmachem India Pvt., Ltd. | 91-80-22891000 | Karnataka, India | 55 | 58 | Inquiry |