ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >GPCR & G Protein >CXCR antagonist >Plerixafor 8HCl (AMD3100 8HCl)

Plerixafor 8HCl (AMD3100 8HCl)

CAS No.: 155148-31-5

Chemical Name:: Plerixafor 8HCl (AMD3100 8HCl)

Synonyms: JM3100;SID791;CS-907;AMD3100;Bicyclam;BISCYCLAM;AMD3100 HCl;SID791 8HCl;JM 3100 8HCl;AMD3100 8HCl

CBNumber:: CB9453984

Molecular Formula:: C28H54N8

Molecular Weight:: 502.78

MOL File:: 155148-31-5.mol

MSDS File:: SDS

Modify Date:: 2024/6/4 15:29:52

Request For Quotation

Plerixafor 8HCl (AMD3100 8HCl) Properties

Melting point	188 - 193°C (dec.)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	H₂O: ≥10 mg/mL, clear
form	solid
color	White
Water Solubility	Soluble in water (100mM)
Stability	Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months.

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS05,GHS02
Signal word	Danger
Hazard statements	H314-H226
Precautionary statements	P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P403+P235-P405
Safety Statements	22-24/25
WGK Germany	3

Plerixafor 8HCl (AMD3100 8HCl) price More Price(5)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	A5602	AMD3100 octahydrochloride hydrate ≥97% (NMR), solid	155148-31-5	5MG	₹12427.1	2022-06-14	Buy
Sigma-Aldrich	239825	InSolution CXCR4 Antagonist I, AMD3100 - CAS 155148-31-5 - Calbiochem InSolution CXCR4 Antagonist I, AMD3100, CAS 155148-31-5, is a 50 mM (15 mg/308 μL) solution of CXCR4 Antagonist I, AMD3100 (Cat. No. 239820) in H?O.	155148-31-5	15MG	₹14970	2022-06-14	Buy
Sigma-Aldrich(India)	239825	InSolution CXCR4 Antagonist I, AMD3100 - CAS 155148-31-5 - Calbiochem InSolution CXCR4 Antagonist I, AMD3100, CAS 155148-31-5, is a 50 mM (15 mg/308 μL) solution of CXCR4 Antagonist I, AMD3100 (Cat. No. 239820) in H?O.	155148-31-5	15MG	₹14970	2022-06-14	Buy
Sigma-Aldrich	239820	CXCR4 Antagonist I, AMD3100 - CAS 155148-31-5 - Calbiochem The CXCR4 Antagonist I, AMD3100, also referenced under CAS 155148-31-5, controls the biological activity of CXCR4. This small molecule/inhibitor is primarily used for Cell Signaling applications.	155148-31-5	5MG	₹9380	2022-06-14	Buy
Sigma-Aldrich(India)	239820	CXCR4 Antagonist I, AMD3100 - CAS 155148-31-5 - Calbiochem The CXCR4 Antagonist I, AMD3100, also referenced under CAS 155148-31-5, controls the biological activity of CXCR4. This small molecule/inhibitor is pr	155148-31-5	5MG	₹9380	2022-06-14	Buy

Product number	Packaging	Price	Buy
A5602	5MG	₹12427.1	Buy
239825	15MG	₹14970	Buy
239825	15MG	₹14970	Buy
239820	5MG	₹9380	Buy
239820	5MG	₹9380	Buy

Plerixafor 8HCl (AMD3100 8HCl) Chemical Properties,Uses,Production

Uses

Plerixafor 8HCl (AMD3100 8HCl) is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively - See more at: http://www.selleckchem.com/products/plerixafor-8hcl-db06

General Description

A symmetrical bicyclam compound that antagonizes CXCL12 (SDF1) binding to CXCR4 (IC₅₀ = 108 and 245 nM using rat and human CXCR4, respectively) and inhibits SDF1-induced Ca²⁺ flux (by 100% at 100 ng/ml in SUP-T1 and THP-1 cultures) as well as CXCR4-, but not CCR5-, mediated HIV infection (IC₅₀ ≤200 nM), while enhancing the binding of SDF1 to CXCR7 (by ~60% at 1 mM with CXCR7-expressing HEK293T cells) and SDF1-induced β-arrestin recruitment to CXCR7 (EC₅₀ = 6.48 and 11.8 nM, in the presence and absence of 10 μM AMD3100, respectively). Administration AMD3100 via intravenous infusion is also reported to result in hematopoietic stem cell mobilization in humans, dogs, and mice in vivo. Exhibits no inhibitory effects against chemokine-induced signaling via CXCR1/2/3 or CCR1/2/3/4/5/6/7/8/9.

Biological Activity

Highly selective CXCR4 chemokine receptor antagonist (IC 50 values are 0.02 - 0.13 and > 25 μ M for CXCR4 and all other chemokine receptors respectively). Switches inflammatory responses from Th2 to Th1 type and reduces airway hyperresponsiveness in a mouse model of asthma. Potently inhibits HIV-1 and HIV-2 replication in vitro (EC 50 = 4 - 35 nM) and mobilizes hematopoietic stem cells in vivo .

Clinical Use

Plerixafor hydrochloride, a chemokine CXCR4 (SDF-1) antagonist, was launched by Genzyme for the treatment of enhancing mobilization of hematopoietic stem cells for autologous transplantation in patients with lymphoma and enhancing mobilization of hematopoietic stem cells for transplantation in patients with multiple myeloma. Being a CXCR4 antagonist, a specific cellular chemokine receptor, plerixafor triggers the rapid movement of stem cells out of the bone marrow and into circulating blood where the stem cells can be collected for use in stem cell transplants. Regarding its use for cardiac applications, some clinical data suggests that the presence of stem cells circulating in the bloodstream or directly injected into the hearts of patients who have suffered a heart attack may result in improved cardiac function.

Plerixafor 8HCl (AMD3100 8HCl) Preparation Products And Raw materials

Raw materials

Preparation Products

Plerixafor 8HCl (AMD3100 8HCl) Suppliers

Global( 194)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	China	12459	58	Inquiry
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	China	2503	58	Inquiry
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	China	20361	58	Inquiry
Ouhuang Engineering Materials (Hubei) Co., Ltd	+86-86177	China	2952	58	Inquiry
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	China	3002	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Pharma Affiliates	58
Hebei Mojin Biotechnology Co., Ltd	58
Henan Bao Enluo International TradeCo.，LTD	58
Henan Fengda Chemical Co., Ltd	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
ATK CHEMICAL COMPANY LIMITED	60

Plerixafor 8HCl (AMD3100 8HCl) Spectrum

Plerixafor 8HCl (AMD3100 8HCl)(155148-31-5)MS Plerixafor 8HCl (AMD3100 8HCl)(155148-31-5)¹HNMR

155148-31-5(Plerixafor 8HCl (AMD3100 8HCl))Related Search:

N,N-Dimethyldodecylamine N-Methyl-2-pyrrolidone Dichloromethylphenylsilane Heptamethyldisilazane Hexamethyldisilazane

4,4'-Diphenylmethane diisocyanate Methyltriphenylphosphonium bromide Methylene Blue Propafenone Hydrochloride 1,4,8,11-Tetrakis[(4-methylphenyl)sulfonyl]-1,4,8,11-tetraazacyclotetradecane

Plerixafor PROTRIPTYLINE HYDROCHLORIDE Pramipexole Impurity 4 PLERIXAFOR Tetradecane

METHYL-2-PYRROLIDONE 1-Benzyl-1,4,8,11-tetraazacyclotetradecane 1,4,8,11-TETRAAZACYCLOTETRADECANE

chevron_left

1of4

chevron_right

SID791 AMD3100 BISCYCLAM JM3100 AMD3100 OCTAHYDROCHLORIDE HYDRATE ANHYDROUS amd3100 octahydrochloride hydrate 1,1'-[1,4-Phenylenebis-(methylene)]-bis-(1,4,8,11-tetraazacyclotetradecane) octahydrochloride, min. 95 % (NMR) AMD3100 hydrate octahydrochloride JM3100, SID791, 1,1μ-[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane octahydrochloride 1,1'-[1,4-Phenylenebis(methylene)]bis[1,4,8,11-tetraazacyclotetradecane] 1,1'-[1,4-PHENYLENEBIS(METHYLENE)]BIS-1,4,8,11-TETRAAZACYCLOTETRADECANE OCTAHYDROCHLORIDE 1,4,8,11-Tetraazacyclotetradecane, 1,1'-(1,4-phenylenebis(methylene))bis-, octahydrochloride Bicyclam Plerixafor hydrochloride Plerixafor hcl Plerixafor (hydrochloride hydrate) Plerixafor HCL(JM 3100) Plerixafor 8HCl (DB06809) Plerixafor (octahydrochloride) Plerixafor 8HCl (AMD3100 8HCl) Plerixafor(SynonyM: AMD3100 octahydrochloride hydrate) 1,4,8,11-Tetraazacyclotetradecane, 1,1'-[1,4-phenylenebis(methylene)]bis-, hydrochloride (1:8) JM 3100 8HCl AMD 3100 octahydrochloride(8HCl) AMD 3100 octahydrochloride, >=98% Plerixafor 8HCl 1,1'-[1,4-Phenylenebis-(methylene)]-bis-(1,4,8,11-tetraazacyclotetradecane) octahydrochloride hydrate AMD3100 HCl JM3100 octahydrochloride SID791 octahydrochloride InSolution? CXCR4 Antagonist I, AMD3100 CXCR4 Antagonist I, AMD3100 AMD3100 OCTAHYDROCHLORIDE AMD3100 OCTAHYDROCHLORIDE;AMD-3100; AMD 3100 CS-907 1,1'-[1,4-Phenylenebis(methylene)]bis[1,4,8,11-tetraazacyclotetradecane] hydrochloride (1:8) InSolution CXCR4 Antagonist I, AMD3100 - CAS 155148-31-5 - Calbiochem CXCR4 Antagonist I, AMD3100 - CAS 155148-31-5 - Calbiochem Plerixafor-d8 8HCl AMD3100 8HCl Plerixafor Hydrochloride (1:8) 1,4-Bis[(1,4,8,11-tetraazacyclotetradecan-1-yl)methyl]benzene Octahydrochloride Plerixafor 8HCl (AMD3100 8HCl) USP/EP/BP Plerixafor hydrochloride salt AMD 3100 octahydroch Plerixafor 8HCl (AMD3100) 1,1'-[1,4-Phenylenebis(methylene)]bis[1,4,8,11-tetraazacyclo... 1-[[4-(1,4,8,11-Tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecaneoctahydrochloride Plerixafor 13C6 Hydrochloride Plerixafore 8HCl Plerixafor (AMD3100) 8HCl SID791 8HCl Plerixafor-(phenylene-d4) 4,4’,8,8’,11,11’-Hexatrifluoroacetate 1,1'-[1,4-Phenylenebis(methylene)]bis[1,4,8,11-tetraazacyclotetradecane JM3100 octahydrochloride|||Plerixafor 8HCl (AMD3100 8HCl)|||Plerixafor 8HCl|||SID791 octahydrochloride|||AMD 3100 octahydrochloride|||JM 3100 8HCl 155148-31-5 C28H54N8 C28H54N88HClxH2O