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ChemicalBook > Product Catalog >Organic Chemistry >Carboxylic acids and derivatives >Carboxylic acid esters and derivatives >4,4'-Diphenylmethane diisocyanate

4,4'-Diphenylmethane diisocyanate

4,4'-Diphenylmethane diisocyanate Structure
CAS No.
101-68-8
Chemical Name:
4,4'-Diphenylmethane diisocyanate
Synonyms
MDI;methylene;Methylene diphenyl diisocyanate;DIPHENYLMETHANE DIISOCYANATE;DESMODUR;MBI;yiqingsuanzhi;methylenediphenyldiisocyanate;BIS(4-ISOCYANATOPHENYL)METHANE;Isonate
CBNumber:
CB8117582
Molecular Formula:
C15H10N2O2
Molecular Weight:
250.25
MOL File:
101-68-8.mol
MSDS File:
SDS
Modify Date:
2024/3/14 15:18:27
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4,4'-Diphenylmethane diisocyanate Properties

Melting point 38-44 °C
Boiling point 392 °C
Density 1.19
vapor pressure 0.066 hPa (20 °C)
refractive index 1.5906 (estimate)
Flash point 196 °C
storage temp. -20°C
solubility 2g/l (decomposition)
Specific Gravity 1.180
color White to Almost white
explosive limit 0.4%(V)
Water Solubility decomposes
FreezingPoint 37℃
Sensitive Moisture Sensitive/Lachrymatory
BRN 797662
Exposure limits TLV-TWA 0.051 mg/m3 (0.005 ppm) (ACGIH and NIOSH); ceiling (air) 0.204 mg/m3 (0.02 ppm)/10 min (NIOSH and OSHA); IDLH 102 mg/m3 (10 ppm).
Dielectric constant 10.0（Ambient）
Stability Stable. Combustible. Incompatible with strong oxidizing agents. Reacts violently with alcohols.
CAS DataBase Reference 101-68-8(CAS DataBase Reference)
IARC 3 (Vol. 19, Sup 7, 71) 1999
NIST Chemistry Reference Benzene, 1,1'-methylenebis[4-isocyanato-(101-68-8)
EPA Substance Registry System 4,4'-Methylenedi(phenyl isocyanate) (101-68-8)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS08
Signal word  Danger
Hazard statements  H315-H317-H319-H332-H334-H335-H351-H373
Precautionary statements  P202-P260-P280-P302+P352-P305+P351+P338-P308+P313
Hazard Codes  Xn,T,C
Risk Statements  42/43-36/37/38-20-48/20-40
Safety Statements  45-36/37-23
RIDADR  2206
OEB D
OEL TWA: 0.05 mg/m3 (0.005 ppm), Ceiling: 0.2 mg/m3 (0.020 ppm) [10-minute]
WGK Germany  1
RTECS  NQ9350000
Autoignition Temperature >600 °C
Hazard Note  Toxic/Corrosive/Lachrymatory/Moisture Sensitive
TSCA  Yes
HazardClass  6.1
PackingGroup  II
HS Code  29291090
Toxicity LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 9000 mg/kg
IDLA 75 mg/m3
NFPA 704
1
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4,4'-Diphenylmethane diisocyanate price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 8.20797 Diphenylmethane 4,4′-diisocyanate (mixture of di-and triisocyanates) for synthesis 101-68-8 100ML ₹5480.01 2022-06-14 Buy
Sigma-Aldrich(India) 8.20797 Diphenylmethane 4,4′-diisocyanate (mixture of di-and triisocyanates) for synthesis 101-68-8 500ML ₹15630 2022-06-14 Buy
Sigma-Aldrich(India) 256439 4,4′-Methylenebis(phenyl isocyanate) 98% 101-68-8 50G ₹2132.53 2022-06-14 Buy
Sigma-Aldrich 256439 4,4′-Methylenebis(phenyl isocyanate) 98% 101-68-8 500G ₹4492.38 2022-06-14 Buy
Sigma-Aldrich(India) 256439 4,4′-Methylenebis(phenyl isocyanate) 98% 101-68-8 500G ₹4492.38 2022-06-14 Buy
Product number Packaging Price Buy
8.20797 100ML ₹5480.01 Buy
8.20797 500ML ₹15630 Buy
256439 50G ₹2132.53 Buy
256439 500G ₹4492.38 Buy
256439 500G ₹4492.38 Buy

4,4'-Diphenylmethane diisocyanate Chemical Properties,Uses,Production

Description

4,4'-Diphenylmethane-diisocyanate (MDI) is used in the manufacture of various polyurethane products - elastic and rigid foams, paints, lacquers, adhesives, binding agents, synthetics rubbers, and elastomeric fibers.

Chemical Properties

white to light yellow flakes or crystals

Uses

Diphenyl methane diisocyanate (MDI) is widely used in polyurethane coatings, this product is made of polyurethane foam used as a warm (cold), building materials, vehicle, ship parts; masterwork can made car Block, buffer, synthetic leather, non plastic polyurethane, polyurethane elastic fiber, no plastic elastic fibers, films, adhesives.

Preparation

Phosgene (800 g, 8 mol) (for a safe source) was dissolved in o-dichlorobenzene (2000 mL), and the resulting solution was cooled in an ice-salt bath. To the stirred solution, a hot solution of 4,4'-diaminodiphenylmethane (200 g, 1.01 mol) in o-dichlorobenzene (1000 mL) was slowly added through a heated dropping funnel. The rate of addition was regulated so that the temperature of the phosgene solution did not rise substantially above 0°C. The fine suspension that resulted was slowly heated and additional phosgene (700 g, 7.1 mol) was added at 130 °C until a clear solution appeared. After purging with carbon dioxide, the solvent was removed in vacuo and the product was purified by vacuum distillation. At 156–158 °C (0.1 mmHg), 215 g (0.85 mol, 84%) of 4,4’-diphenylmethane diisocyanate was obtained. Several procedures for the preparation of isocyanates with phosgene have been described. Nevertheless, many of them require the delivery of gaseous phosgene from an external source, such as a pressurized cylinder.

Definition

ChEBI: A diisocyanate consisting of diphenylmethane with two isocyanate groups at the 4- and 4'-positions.

General Description

Diphenylmethane-4,4-diisocyanate is a light yellow colored solid. 4,4'-Diphenylmethane diisocyanate is not soluble in water. 4,4'-Diphenylmethane diisocyanate may be toxic by ingestion, inhalation, or skin absorption. If in a solution 4,4'-Diphenylmethane diisocyanate may or may not burn depending on the nature of the material and/or the solvent. It's used to make plastics.

Air & Water Reactions

4,4'-Diphenylmethane diisocyanate is not soluble in water.

Reactivity Profile

Isocyanates and thioisocyanates, such as 4,4'-Diphenylmethane diisocyanate, are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence, [Wischmeyer(1969)].

Health Hazard

Breathlessness, chest discomfort, and reduced pulmonary function.

Fire Hazard

Noncombustible; flash point (open cup) 202°C (395°F). MDI reactions with strong oxidizers, acids, and bases can be vigorous.

Contact allergens

MDI is used in the manufacture of various polyurethane products: elastic and rigid foams, paints, lacquers, adhesives, binding agents, synthetic rubbers, and elastomeric fibers.

Safety Profile

Poison by inhalation. Mildly toxic by ingestion. Human systemic effects by inhalation: increased immune response and body temperature. A skin and eye irritant. An allergic sensitizer. Questionable carcinogen. Mutation data reported. A flammable liquid. When heated to decomposition it emits toxic fumes of NOx and SOx.

Potential Exposure

MDI is used in the production of polyurethane foams and plastics; polyurethane coatings; elastomers, and thermoplastic resins.

Environmental Fate

Due to its low vapor pressure (0.000 62 Pa at 20 ℃), MDI partitioning to the atmosphere is limited; and vapors are rapidly eliminated by reaction with hydroxyl radicals (22 h half-life). Degradation by either direct photolysis or hydrolysis by water vapor to methylenedianiline (MDA) does not play a significant role in the atmospheric fate of MDI. In water, the isocyanate group of MDI can be rapidly hydrolyzed to an amine (<1 min half-life) that in turn reacts at a much faster rate with another isocyanate group to yield urea. Because MDI has two isocyanate groups, these reactions lead to cross-linked polyureas, which are inert, insoluble solids. Unless MDI is well dispersed in water, these processes result in the formation of a solid polyurea crust that encases the unreacted material, restricts both water ingress and amine egress, and leads to higher yields of polyurea. Under stirred aqueous conditions, the fraction of 4,4'-MDI converted to 4,4'-MDA is less than 1%; unstirred, the fraction is 0.005%. MDI released to soil will not exhibit significant transport to other environmental media due to the favored reaction with water to form inert polyureas and binding to the soil biomass. As expected, pMDI and the waterinsoluble oligo- and polyureas that form when pMDI enters an aqueous environment showed no biodegradation over 28 days in a guideline study.

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required

Incompatibilities

May form explosive mixture with air. Isocyanates are highly flammable and reactive with many compounds, even with themselves. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Reaction with moist air, water or alcohols may form amines and insoluble polyureas and react exothermically, releasing toxic, corrosive or flammable gases, including carbon dioxide; and, at the same time, may generate a violent release of heat increasing the concentration of fumes in the air. Incompatible with amines, aldehydes, alkali metals, ammonia, carboxylic acids, caprolactum, alkaline materials, glycols, ketones, mercaptans, hydrides, organotin catalysts, phenols, strong acids, strong bases, strong reducing agents such as hydrides, urethanes, ureas. Elevated temperatures or contact with acids, bases, tertiary amines, and acylchlorides may cause explosive polymerization. Attacks some plastics, rubber and coatings. May accumulate static electrical charges, and may cause ignition of its vapors. Unstable above 100F/38C. Polymerizes at temperatures above 204C. Contact with metals may evolve flammable hydrogen gas.

Waste Disposal

Controlled incineration (oxides of nitrogen are removed from the effluent gas by scrubbers and/or thermal devices).

4,4'-Diphenylmethane diisocyanate Preparation Products And Raw materials

Raw materials

CARBON MONOXIDE Chlorine Formaldehyde Aniline Nitric acid
Sodium hydroxide
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Preparation Products

Polyurethane Polyurethane rigid foam TRIPHENYLTIN HYDRIDE 2-BIPHENYLYL ISOCYANATE

4,4'-Diphenylmethane diisocyanate Suppliers

Global( 272)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
Otto Chemie Pvt. Ltd. +91 9820041841 Mumbai, India 5873 58 Inquiry
Alfa Aesar 1 800 209 7001 Maharashtra, India 6913 58 Inquiry
JEEVAN ENTERPRISES 08046067515 Hyderabad, India 33 58 Inquiry
Ramo Enterprises 07942546172 Andhra Pradesh, India 1 58 Inquiry
Labdhi Chem 08048972621 Mumbai, India 84 58 Inquiry
Mahesh Traders 09830852272 Kolkata, India 2 58 Inquiry
Kumar Chemicals 08046057707 Mumbai, India 4 58 Inquiry
Palskem 08048605144 Maharashtra, India 2 58 Inquiry
Triveni chemicals 08048762458 New Delhi, India 6093 58 Inquiry
Supplier Advantage
TCI Chemicals (India) Pvt. Ltd. 58
Otto Chemie Pvt. Ltd. 58
Alfa Aesar 58
JEEVAN ENTERPRISES 58
Ramo Enterprises 58
Labdhi Chem 58
Mahesh Traders 58
Kumar Chemicals 58
Palskem 58
Triveni chemicals 58

Related articles

4,4'-Diphenylmethane diisocyanate Spectrum

4,4'-Diphenylmethane diisocyanate(101-68-8)MS4,4'-Diphenylmethane diisocyanate(101-68-8)1HNMR4,4'-Diphenylmethane diisocyanate(101-68-8)13CNMR4,4'-Diphenylmethane diisocyanate(101-68-8)IR14,4'-Diphenylmethane diisocyanate(101-68-8)IR2

101-68-8(4,4'-Diphenylmethane diisocyanate)Related Search:

BENZOYL ISOCYANATE Tolylene-2,4-diisocyanate PHENYL VALERATE Methylene dithiocyanate Benzyl isocyanate
Isophorone diisocyanate Diphenylmethane Phenyl butyrate 3,4'-DIAMINODIPHENYLMETHANE Diphenyl ether
Phenyl salicylate Chlorodiphenylmethane PHENYL ACETATE 1,3-Bis(isocyanatomethyl)benzene Hexyl isocyanate
Hexamethylene Diisocyanate Phenyl isothiocyanate Methyltriphenylphosphonium bromide Methylene Diphenyl Diisocyanate
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para,para’-diphenylmethanediisocyanate para,para’-methylenebis(phenylisocyanate) Rubinate 44 Rubinate LF-168 rubinate44 METHYLENEBIS(P-PHENYL ISOCYANATE) METHYLENEDIPHENYL 4,4'-DIISOCYANATE METHYLENEDI-P-PHENYL DIISOCYANATE METHYLENE DI-P-PHENYLENE DIISOCYANATE Diphenyl methene-4，4′diisocyanate DIPHENYLMETHAN-4,4'-DIISOCYANATE DIPHENYLMETHANE-4,4'-DIISOCYANATE VANCHEM HM-4346 VANCHEM HM-50 P,P'-DIPHENYLMETHANE DIISOCYANATE IMO Pollution Category 4,4-Diisocyanodiphenylmethane Methylene di-p-phenyl diisocyanate, 99.5%, flakes Methylene di-p-phenyl diisocyanate, flakes Methylenebis(1,4-phenylene) diisocyanate Methylenebis(1,4-phenylene)diisocyanate 4,4′-Methylenebis(phenyl isocyanate) Bis(4-isocyanatophenyl)methane 4,4'-Methylenebis(phenyl isocyanate) ,97.5% Methylene di-p-phenyl diisocyanate, flakes, 99.5% 4,4′-MDI,4,4′-MDI, 4,4′-Methylenebis(phenyl isocyanate), Bis(4-isocyanatophenyl)methane Methylene di-p-phenylene diisocyanate 5g [101-68-8] 4,4′-Methylenebis(phenyl isocyanate),4,4′-MDI, Bis(4-isocyanatophenyl)methane 4,4'-Diphenylmethane diisocyanate 98% Methylene di-p-phenyl diisocyante 1,1-Methylenebis4-Isoc Methylene di-p-phenyl diisocyanate, 98%, flakes Methylene di-p-phenyl diisocyanate, flakes, 99.5% 500GR Bis(4-isocyanatophenyl)methane 4,4'-Methylenebis(phenyl Isocyanate) 4,4'-Diphenylmethane Diisocyanate 1,1'-Methanediylbis(4-isocyanatobenzene) 98% 4,4'-Diisocyanatodiphenylmethane, MDI Methylene di-p-phenyl diisocyanate, stabilized flakes (polymerizes easily), 99.50% Methylenedi-p-phenyl diisocyanate, 98.5% 4,4'-Methylenebis(phenyl isocyanate), 98%, stab. with 450ppm BHT and 450ppm triphenyl phosphite METHYLENEBISPHENYLDIISOCYANATE DIPHENYLMETHANEISOCYANATE METHYLENEDIPHENYLISOCYANATE METHYLENEDIPHENYLDIIOSCYANATE METHYLENEDIPHENOLDIISOCYANATE METHYLENEBI-(PHENYLDI-ISOCYANATE) METHLENEDIPHENYLISOCYANATE Diphenylmethandiisocyanat 4,4''-METHYLENEBIS(PHENYL ISOCYANATE) , STABILIZED WITH 450PPM BHT AND 450PPM TRIPHENYL PHOSPHITE 1,1’-methylenebis(4-isocyanato-benzen 1,1’-methylenebis[4-isocyanato-benzen 1,1’-methylenebis[4-isocyanato-Benzene 1,1’-methylenebis[4-isocyanotobenzene] 1,1-Methylenebis4-isocyanatobenzene 4,4'-methylenedi(4,1-phenylene) isocyanate Methylene diphenyl diisocyanate (monomeric and pol? METHYLENE BISPHENYL ISOCYANATE Methylenedi-p-phenyl diisocyanate, stabilized flakes, contains 1.5% 2,4[-isomer METHYLENEDI-P-PHENYL DISOCYANATE, 1000MG METHYLENEDI-P-PHENYL DISOCYANATE 1000M& 4,4'-METHYLENEBIS(PHENYL ISOCYANATE), 98 %