PLERIXAFOR
![PLERIXAFOR Structure](CAS/GIF/110078-46-1.gif)
- CAS No.
- 110078-46-1
- Chemical Name:
- PLERIXAFOR
- Synonyms
- AMD310;CS-269;Mozobil;AMD-3329;Plerixafo;PLERIXAFOR;Sdz sid 791;Unii-S915p5499n;MOZOBIL PLERIXAFOR;Plerixafor(AMD3100)
- CBNumber:
- CB11011749
- Molecular Formula:
- C28H54N8
- Molecular Weight:
- 502.78
- MOL File:
- 110078-46-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/8/22 17:11:26
Melting point | 122-125°C |
---|---|
Boiling point | 657.5±55.0 °C(Predicted) |
Density | 0.962 |
storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
solubility | Methanol (Slightly), Water (Slightly) |
form | Solid |
pka | 10.60±0.20(Predicted) |
color | White to Pale Beige |
Stability | Hygroscopic |
CAS DataBase Reference | 110078-46-1 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H319-H315 | |||||||||
Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
HS Code | 29339900 | |||||||||
NFPA 704 |
|
PLERIXAFOR price More Price(2)
PLERIXAFOR Chemical Properties,Uses,Production
Description
Autologous hematopoietic stem cell (HSC) transplantation, a standard
treatment for hematological malignancies, such as non-Hodgkin’s lymphoma or multiple myeloma, involves collection of HSCs from the
patient, chemo- or radiotherapy of the patient to eliminate malignant cells,
and retransplantation of the stored HSCs.
Plerixafor is a potent antagonist of the CXCR4 chemokine receptor and a first-in-class drug for stem cell mobilization. CXCR4
is specific for stromal-derived-factor-1 (SDF-1), a molecule endowed with
potent chemotactic activity forlymphocytes. Because the interaction between
SDF-1 and CXCR4 plays an important role in holding HSCs in the bone
marrow, drugs that block the activity of CXCR4 receptor are capable of
mobilizing HSCs into the bloodstream. In vitro, plerixafor potently blocks
SDF-1 binding of CXCR4 and inhibits SDF-1-induced calcium flux
(IC50 = 0.01-0.13 mg/mL) and chemotaxis (IC50 = 0.13 mg/mL) in several
different cell types.
Plerixafor, in combination with G-CSF, is specifically
indicated to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin’s lymphoma and multiple myeloma.
Chemical Properties
White Solid
Side effects
The most common adverse reactions (occurring in more than 10% of patients) observed during plerixafor use include diarrhea, nausea, fatigue, injection-site reactions, headache, arthralgia, dizziness, and vomiting.
PLERIXAFOR Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
Dr. Reddy's Laboratories Ltd | +91-4049002900 +91-4049002900 | Hyderabad, India | 165 | 58 | Inquiry |
Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
Gland Pharma Ltd | +91-7075736524 +91-9700602423 | Telangana, India | 44 | 58 | Inquiry |
Biophore India Pharmaceuticals Pvt Ltd | +91-9100031592 +91-9030907714 | Telangana, India | 134 | 58 | Inquiry |
Mylan Laboratories Ltd | +91-4023550543 +91-4030866666 | Telangana, India | 150 | 58 | Inquiry |
Apicore Pharmaceuticals Pvt Ltd | +91-2662267177 +91-2662267166 | Gujarat, India | 181 | 58 | Inquiry |
Aspen Biopharma Labs Pvt Ltd | +91-9248058660 +91-9248058662 | Telangana, India | 234 | 58 | Inquiry |
ALEMBIC PHARMACEUTICALS LTD | +91 40 23704923 / 24 / 25 | New Delhi, India | 108 | 58 | Inquiry |
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
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