PLERIXAFOR
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PLERIXAFOR 속성
- 녹는점
- 122-125°C
- 끓는 점
- 657.5±55.0 °C(Predicted)
- 밀도
- 0.962
- 저장 조건
- Keep in dark place,Inert atmosphere,2-8°C
- 용해도
- 메탄올(약간 용해됨), 물(약간 용해됨)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 10.60±0.20(Predicted)
- 색상
- 흰색에서 옅은 베이지까지
- 안정성
- 흡습성
- CAS 데이터베이스
- 110078-46-1
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| HS 번호 | 29339900 |
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PLERIXAFOR C화학적 특성, 용도, 생산
개요
Autologous hematopoietic stem cell (HSC) transplantation, a standard treatment for hematological malignancies, such as non-Hodgkin’s lymphoma or multiple myeloma, involves collection of HSCs from the patient, chemo- or radiotherapy of the patient to eliminate malignant cells, and retransplantation of the stored HSCs.Plerixafor is a potent antagonist of the CXCR4 chemokine receptor and a first-in-class drug for stem cell mobilization. CXCR4 is specific for stromal-derived-factor-1 (SDF-1), a molecule endowed with potent chemotactic activity forlymphocytes. Because the interaction between SDF-1 and CXCR4 plays an important role in holding HSCs in the bone marrow, drugs that block the activity of CXCR4 receptor are capable of mobilizing HSCs into the bloodstream. In vitro, plerixafor potently blocks SDF-1 binding of CXCR4 and inhibits SDF-1-induced calcium flux (IC50 = 0.01-0.13 mg/mL) and chemotaxis (IC50 = 0.13 mg/mL) in several different cell types. Plerixafor, in combination with G-CSF, is specifically indicated to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin’s lymphoma and multiple myeloma.
화학적 성질
White Solid부작용
The most common adverse reactions (occurring in more than 10% of patients) observed during plerixafor use include diarrhea, nausea, fatigue, injection-site reactions, headache, arthralgia, dizziness, and vomiting.PLERIXAFOR 준비 용품 및 원자재
원자재
준비 용품
PLERIXAFOR 공급 업체
글로벌( 277)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Anhui Ruihan Technology Co., Ltd | +8617756083858 |
daisy@anhuiruihan.com | China | 973 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21639 | 55 |
| Hangzhou FandaChem Co.,Ltd. | +8615858145714 |
FandaChem@Gmail.com | China | 9220 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32820 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29885 | 58 |
| Biochempartner | 0086-13720134139 |
candy@biochempartner.com | CHINA | 965 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28172 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
| Beijing Yibai Biotechnology Co., Ltd | 0086-182-6772-3597 |
sales04@yibaibiotech.com | CHINA | 419 | 58 |
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시스백금
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