PLERIXAFOR
PLERIXAFOR
- CAS:
- 110078-46-1
- MF:
- C28H54N8
- MW:
- 502.78
Suppliers by country/region
Company Type
Properties
- Melting point:
- 122-125°C
- Boiling point:
- 657.5±55.0 °C(Predicted)
- Density
- 0.962
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- Methanol (Slightly), Water (Slightly)
- form
- Solid
- pka
- 10.60±0.20(Predicted)
- color
- White to Pale Beige
- Stability:
- Hygroscopic
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H319-H315
- Precautionary statements
- P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
- HS Code
- 29339900
Use
Plerixafor inhibits CXCL12-mediated chemotaxis with a potency lightly better than its affinity for CXCR4. Plerixafor also antagonizes SDF-1/CXCL12 ligand binding with an IC50 of 651 nM. Plerixafor inhibits SDF-1 mediated GTP-binding, SDF-1 mediated calcium flux and SDF-1 stimulated chemotaxis with IC50 of 27 nM, 572 nM and 51 nM, respectively. Plerixafor does not inhibit calcium flux against cells expressing CXCR3, CCR1, CCR2b, CCR4, CCR5 or CCR7 when stimulated with their cognate ligands, nor does Plerixafor inhibit receptor binding of LTB4. Plerixafor does not, on its own, induce a calcium flux in the CCRF–CEM cells, which express multiple GPCRs including CXCR4, CCR4 and CCR7.
17 India supplier list of "PLERIXAFOR"
- Product Name:Plerixafor
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:Plerixafor
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Hyderabad,INDIA
- Product Name:Plerixafor
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
- Product Name:Plerixafor
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Telangana,INDIA
- Product Name:Plerixafor
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
- Product Name:Plerixafor
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:Plerixafor
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:Plerixafor 95%
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.136081
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Plerixafor
- Products Intro:Brand:synzeal | Product Number:153567582
- Company Type: Trader
- Country/Region: Gujarat,INDIA
- Product Name:PLERIXAFOR
- Company Type: Manufacturer
- Country/Region: New Delhi,INDIA