bufeniode
- CAS No.
- 22103-14-6
- Chemical Name:
- bufeniode
- Synonyms
- HF-241;Bufeniod;Proclival;bufeniode;Diiodobuphenine;4-[1-Hydroxy-2-(1-methyl-3-phenylpropylamino)propyl]-2,6-diiodophenol
- CBNumber:
- CB8908821
- Molecular Formula:
- C19H23I2NO2
- Molecular Weight:
- 551.196
- MOL File:
- 22103-14-6.mol
- Modify Date:
- 2023/5/4 17:34:35
SAFETY
Risk and Safety Statements
| Toxicity | LD50 in mice: >600 mg/kg i.p., >2 g/kg orally (Fourneau, Delourme) |
|---|
bufeniode Chemical Properties,Uses,Production
Originator
Proclival,Houde,France,1970
Manufacturing Process
Buphenine is the starting material. See under the alternative name "Nylidrin"
in this publication for synthesis.
24 grams of buphenine hydrochloride are suspended in a mixture of 440 ml of
34% ammonia (specific gravity = 0.89) and 315 ml of water. 41 grams of
iodine dissolved in 1,080 ml of 96% alcohol are added little by little, with
good stirring. During this addition, effected in about 30 min, buphenine
hydrochloride dissolves fairly rapidly, and then the diiodobuphenine
precipitates out as a crystalline powder. Stirring is continued for a further
hour. The precipitate is suction filtered, and then washed with water, with
alcohol and with ether and is finally dried in vacuo in the exsiccator in the
presence of phosphoric anhydride. Thus, about 23 grams of diiodobuphenine
solvated with 1 mol of ethanol are obtained in the form of a microcrystalline
white powder. MP (slow) = 185°C (dec.). MP (inst.): 212°C.
Therapeutic Function
Antihypertensive
bufeniode Preparation Products And Raw materials
bufeniode Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| 3B Scientific Corporation | 847.281.9822 | United States | 6744 | 47 | Inquiry |
| Yick-Vic Chemicals & Pharmaceuticals (HK) Ltd | (852)2541 2772 | China | 6214 | 58 | Inquiry |
| 2A PharmaChem USA | (630) 737-0988 | United States | 6148 | 39 | Inquiry |
| Lanospharma Laboratories Co.,Ltd | 13440048448 | China | 6343 | 56 | Inquiry |
| Leancare Ltd. | +33 962096793 | United Kingdom | 6460 | 42 | Inquiry |
| Shaanxi Dideu Newmaterial Co., Ltd. | 029-63373950 15353716720 | China | 10011 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| 3B Scientific Corporation | 47 |
| Yick-Vic Chemicals & Pharmaceuticals (HK) Ltd | 58 |
| 2A PharmaChem USA | 39 |
| Lanospharma Laboratories Co.,Ltd | 56 |
| Leancare Ltd. | 42 |
| Shaanxi Dideu Newmaterial Co., Ltd. | 58 |