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Phenactropinium chloride

Phenactropinium chloride Structure
CAS No.
3784-89-2
Chemical Name:
Phenactropinium chloride
Synonyms
Phenactropinium;Phenactropinium chloride;3-[Hydroxy(phenyl)acetoxy]-8-methyl-8-(2-oxo-2-phenylethyl)-8-azoniabicyclo[3.2.1]octane;(8-methyl-8-phenacyl-8-azoniabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenylacetate chloride;(8-methyl-8-phenacyl-8-azoniabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenyl-ethanoate chloride;2-hydroxy-2-phenyl-acetic acid (8-methyl-8-phenacyl-8-azoniabicyclo[3.2.1]octan-3-yl) ester chloride
CBNumber:
CB91116431
Molecular Formula:
C24H28ClNO4
Molecular Weight:
0
MOL File:
3784-89-2.mol
Modify Date:
2022/12/21 16:56:50
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Phenactropinium chloride Properties

Melting point 195-197°

Phenactropinium chloride Chemical Properties,Uses,Production

Originator

Trophenium ,American Cyanamid (AHP), US ,1961

Manufacturing Process

330 g (1.2 M) of homatropine were dissolved in 1 liter of dry methyl ethyl ketone and gently refluxed on a water-bath during the gradual addition of a solution of 204 g (1.32 M) redistilled phenacyl chloride in 200 ml of the same solvent. After 10 to 15 minutes 1 g of previously prepared homatropine phenacyl chloride was added to avoid formation of a supersaturated solution of the quaternary compound. Reflux was continued for 9 hours, then the thick suspension was allowed to cool, filtered and washed with 200 ml methyl ethyl ketone to yield 490 g (95%) slightly creamy solid, MP 188°C to 191°C.
For purification the crude quaternary salt was dissolved in hot ethyl alcohol (2 ml/g) and warm dry acetone (8 ml/g) was stirred into the clear filtrate. On cooling, 387 g (78 % recovery) of a pure white powder, MP 195°C to 197°C, were obtained, in which the ionizable chlorine assayed at 99.7% of the theoretical value.

Therapeutic Function

Antihypertensive

Phenactropinium chloride Preparation Products And Raw materials

Raw materials

2-Chloroacetophenone HOMATROPINE

Preparation Products

Phenactropinium chloride Suppliers

Global( 4)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
3B Scientific Corporation 847.281.9822 United States 6744 47 Inquiry
2A PharmaChem USA (630) 737-0988 United States 6148 39 Inquiry
Lanospharma Laboratories Co.,Ltd 13440048448 China 6343 56 Inquiry
Leancare Ltd. +33 962096793 United Kingdom 6460 42 Inquiry
Supplier Advantage
3B Scientific Corporation 47
2A PharmaChem USA 39
Lanospharma Laboratories Co.,Ltd 56
Leancare Ltd. 42

3784-89-2(Phenactropinium chloride)Related Search:

N-PROPYLCYCLOHEPTANAMINE 4-PIPERIDINOL, 1-METHYL-, PROPANOATE, HYDROCHLORIDE Phenactropinium chloride 1-DIPROPYLAMINO-2-PROPANONE HOMATROPINE HYDROCHLORIDE
BETAINE ALDEHYDE CHLORIDE 4-PIPERIDINOL, PROPIONATE, HYDROCHLORIDE 1-piperidinoacetone HOMATROPINE Mepiquat chloride
1-(2-methylpiperidin-1-yl)acetone 1-phenethylpiperidin-4-ol
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(8-methyl-8-phenacyl-8-azoniabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenylacetate chloride (8-methyl-8-phenacyl-8-azoniabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenyl-ethanoate chloride 2-hydroxy-2-phenyl-acetic acid (8-methyl-8-phenacyl-8-azoniabicyclo[3.2.1]octan-3-yl) ester chloride 3-[Hydroxy(phenyl)acetoxy]-8-methyl-8-(2-oxo-2-phenylethyl)-8-azoniabicyclo[3.2.1]octane Phenactropinium chloride Phenactropinium 3784-89-2 C24H28ClNO4