2-Chloroacetophenone
- CAS No.
- 532-27-4
- Chemical Name:
- 2-Chloroacetophenone
- Synonyms
- CN;PHENACYL CHLORIDE;1-Chloroacetophenone;phenacyl;2-CHLORO-1-PHENYLETHANONE;A-CHLOROACETOPHENONE;ALPHA-CHLOROACETOPHENONE;cn[qr];teargas;caf[qr]
- CBNumber:
- CB9387386
- Molecular Formula:
- C8H7ClO
- Molecular Weight:
- 154.59
- MOL File:
- 532-27-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/14 15:18:31
| Melting point | 54-56 °C(lit.) |
|---|---|
| Boiling point | 244-245 °C(lit.) |
| Density | 1.324 g/mL at 25 °C(lit.) |
| vapor pressure | 4 at 20 °C, 14 at 30 °C (quoted, Verschueren, 1983) |
| refractive index | 1.5438 |
| Flash point | 118°C |
| solubility | Soluble in acetone (Weast, 1986). Freely soluble in alcohol, benzene, and ether (Windholz et al., 1983) |
| form | Colorless crystals |
| Water Solubility | insoluble. <0.1 g/100 mL at 19 ºC |
| Sensitive | Moisture Sensitive |
| Merck | 14,2115 |
| BRN | 507950 |
| Exposure limits | NIOSH REL: TWA 0.3 mg/m3 (0.05 ppm), IDLH 15 mg/m3; OSHA PEL: TWA 0.05 ppm (0.3 mg/m3); ACGIH TLV: TWA 0.05 ppm (adopted). |
| Stability | May decompose upon exposure to air or water. Incompatible with bases, amines, alcohols. |
| InChIKey | IMACFCSSMIZSPP-UHFFFAOYSA-N |
| LogP | 1.724 (est) |
| CAS DataBase Reference | 532-27-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Ethanone, 2-chloro-1-phenyl-(532-27-4) |
| EPA Substance Registry System | 2-Chloroacetophenone (532-27-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300-H311+H331-H315-H318-H334-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P310-P302+P352+P312-P304+P340+P311-P305+P351+P338 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25-36/37/38-42/43-23/25-36-23/24/25 | |||||||||
| Safety Statements | 22-26-36/37/39-45-28A-7/9 | |||||||||
| RIDADR | UN 1693 6.1/PG 2 | |||||||||
| OEB | C | |||||||||
| OEL | TWA: 0.3 mg/m3 (0.05 ppm) | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AM6300000 | |||||||||
| F | 9-19 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| Toxicity | LD50 in rats (mg/kg): 41 i.v., 36 i.p., 127 orally; LC50 in rats: 8750 mg/min/m3 (Ballantyne, Swanston) | |||||||||
| IDLA | 15 mg/m3 | |||||||||
| NFPA 704 |
|
2-Chloroacetophenone price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C19686 | 2-Chloroacetophenone 98% | 532-27-4 | 100G | ₹6051.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C19686 | 2-Chloroacetophenone 98% | 532-27-4 | 500G | ₹8118.75 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 77460 | 2-Chloroacetophenone purum, ≥98.0% (GC) | 532-27-4 | 100G | ₹3085.13 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 77460 | 2-Chloroacetophenone purum, ≥98.0% (GC) | 532-27-4 | 500G | ₹8789.9 | 2022-06-14 | Buy |
| ottokemi | C 1970 | 2-Chloroacetophenone 98% | 532-27-4 | 25gm | ₹3006 | 2022-05-26 | Buy |
2-Chloroacetophenone Chemical Properties,Uses,Production
Description
Chloroacetophenone is contained in tear gases (lacrimators). This substance has an important irritative potential but can also be a sensitizer.
Chemical Properties
2-Chloroacetophenone (CN) is a combustible, colorless-to-gray solid. CN has a sharp, irritating odor, has been described as smelling like “apple blossoms.” It may be dissolved in a solvent
Physical properties
Colorless to gray crystalline solid with a sharp, penetrating, irritating odor. The low odor and high odor threshold concentrations were 102 and 150 μg/m3, respectively (Ruth, 1986).
Uses
Riot control agent.
Definition
A strong lachrymator.
General Description
2-chloroacetophenone appears as a white crystalline solid. Denser than water and insoluble in water. Hence sinks in water. A lachrymator: vapors are very irritating to the eyes. Has a floral odor. Used as a riot control agent.
Hazard
The main uses for 2-chloroacetophenone are in tear gas and in chemical Mace. It is a potent eye, throat, and skin irritant. Acute (short-term) inhalation exposure of humans causes burning of the eyes with lacrimation, some degree of blurred vision, possible corneal damage, irritation and burning of the nose, throat, and skin, and burning in the chest with dyspnea. Acute dermal exposure is irritating and can result in first, second, and third degree chemical burns in humans. Squamous hyperplasia of the nasal respiratory epithelium was reported in rats chronically exposed (long-term) via inhalation. EPA has not classified 2-chloroacetophenone with respect to potential carcinogenicity.
Health Hazard
Median lethal dose (mg-min/m3): 11000 (estimated). Median incapacitating dose: 80. Eye/skin toxicity: Temporarily severe eye irritation; mild skin irritation. Rate of action: Instantaneous. Physiological action: Powerfully lacrimatory. Detoxification rate: Rapid. (ANSER)
Fire Hazard
Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
Contact allergens
w-Chloroacetophenone is contained in tear gases (lacrimators). This substance has important irritative potential, but can also be a sensitizer.
Safety Profile
A human poison by inhalation. An experimental poison by ingestion, inhalation, intraperitoneal, and intravenous routes. Human systemic effects by inhalation: lachrymation, conjunctiva irritation, and unspecified eye effects, cough, and dyspnea. A severe eye and moderate skin irritant. Questionable carcinogen with experimental neoplastigenic data by skin contact. A riot control agent. When heated to decomposition it emits toxic fumes of Cl-. See also KETONES.
Potential Exposure
Chloroacetophenone is used as a chemical warfare agent (Agent CN) and as a principal ingredient in the riot control agent Mace. It is also used as a pharmaceutical intermediate. The United States considers agent CN and its mixtures with various chemicals to be obsolete for military deployment.
Environmental Fate
Chemical/Physical. Releases toxic chloride fumes when heated to decomposition (Sax and Lewis, 1987).
Shipping
UN1697 Chloroacetophenone, solid, (CN), Hazard Class: 6.1; Labels: 6.1-Poison Inhalation. UN3416 Chloroacetophenone, liquid, (CN), Hazard Class: 6.1;Labels: 6.1-Poisonous materials. Hazard. Military driver shall be given full and complete information regarding shipment and conditions in case of emergency. AR 50-6 deals specifically with the shipment of chemical agents. Shipments of agent will be escorted in accordance with AR 740-32.
Purification Methods
Crystallise it from MeOH [Tanner J Org Chem 52 2142 1987]. [Beilstein 7 IV 641.]
Incompatibilities
Keep away from water, steam, strong oxidizers. CN reacts with water, forming hydrochloric acid. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. CN reacts slowly with metals, causing mild corrosion and may evolve flammable hydrogen gas.
Waste Disposal
Tear gas-containing waste is dissolved in an organic solvent and sprayed into an incinerator equipped with an afterburner and alkaline scrubber utilizing reaction with sodium sulfide in an alcoholwater solution. Hydrogen sulfide is liberated and collected by an alkaline scrubber.
2-Chloroacetophenone Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SYNGREEN LIFESCIENCES PVT.LTD | +919849474297 | Telangana, India | 82 | 58 | Inquiry |
| Cefa-Cilinas Biotics Pvt Ltd | +91-7875033155 +91-8080701561 | Maharashtra, India | 121 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Ramsun Bio Organics | +91-9742930655 +91-9742475780 | Karnataka, India | 42 | 58 | Inquiry |
| ALS INDIA LIFE SCIENCES | +91-8977036379 +91-8977036379 | Hyderabad, India | 1879 | 58 | Inquiry |
| Anand Agencies | 91-20-24454597 | Maharashtra, India | 2337 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6160 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Dhruvtara Chemicals Pvt. Ltd. | 91 40 27154607 | New Delhi, India | 180 | 56 | Inquiry |
| Supplier | Advantage |
|---|---|
| SYNGREEN LIFESCIENCES PVT.LTD | 58 |
| Cefa-Cilinas Biotics Pvt Ltd | 58 |
| JSK Chemicals | 58 |
| Ramsun Bio Organics | 58 |
| ALS INDIA LIFE SCIENCES | 58 |
| Anand Agencies | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| Central Drug House(P) Ltd. | 58 |
| Triveni chemicals | 58 |
| Dhruvtara Chemicals Pvt. Ltd. | 56 |
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