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ChemicalBook > Product Catalog >Organic Chemistry >Nitrogen Compounds >2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide

2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide

2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide Structure
CAS No.
114289-47-3
Chemical Name:
2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
Synonyms
CI 976;PD 128042;CI-976 (PD 128042);N-(2,4,6-Trimethoxyphenyl)-2,2-dimethyldodecanamide;2,2-DIMETHYL-N-(2,4,6-TRIMETHOXYPHENYL)DODECANAMIDE;2,2-dimethyl-n-(2,4,6-trimethoxyphenyl)-dodecanamid;Dodecanamide, 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)-;inhibit,oral,PD128042,PD 128042,CI-976,Diacylglycerol acyltransferase,PD-128042,Acyltransferase,transferase,secretory,LPAT,acyl-CoA:cholesterol acyltransferase,mono- acylglycerol acyltransferase,endocytic membrane trafficking pathway,ACAT,CI976,Diglyceride acyltransferase,Inhibitor
CBNumber:
CB9130672
Molecular Formula:
C23H39NO4
Molecular Weight:
393.56
MOL File:
114289-47-3.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:40
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2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide Properties

storage temp. 2-8°C
solubility DMSO: >10mg/mL
form solid
color White to off-white
InChI InChI=1S/C23H39NO4/c1-7-8-9-10-11-12-13-14-15-23(2,3)22(25)24-21-19(27-5)16-18(26-4)17-20(21)28-6/h16-17H,7-15H2,1-6H3,(H,24,25)
InChIKey WAFNZAURAWBNDZ-UHFFFAOYSA-N
SMILES C(NC1=C(OC)C=C(OC)C=C1OC)(=O)C(C)(C)CCCCCCCCCC

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  3

2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) C3743 CI 976 >98% (HPLC), solid 114289-47-3 5MG ₹16518.95 2022-06-14 Buy
Product number Packaging Price Buy
C3743 5MG ₹16518.95 Buy

2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide Chemical Properties,Uses,Production

Description

Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT-1) is a sterol O-acyltransferase that catalyzes the formation of fatty acid-cholesterol esters, an important step in lipoprotein assembly and dietary cholesterol absorption. CI-976 is a potent, selective inhibitor of ACAT-1 (IC50 = 73 nM). It is orally bioavailable and decreases plasma total cholesterol, very low density lipoprotein (VLDL) cholesterol, LDL cholesterol, apolipoprotein B, liver cholesteryl esters, and VLDL and LDL cholesteryl ester content in rabbits given a diet that induces hypercholesterolemia. CI-976 also diminishes atherosclerotic activity in hypercholesterolemic rabbits.

Uses

CI-976 (2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide) is a selective inhibitor of Acyl-coenzyme A: cholesterol Acyltransferase 1 (ACAT-1), a sterol O-acetyltransferase that catalyzes information of fatty acid-cholesterol esters. Orally bioavailable and decreses plasma total cholesterol

Biological Activity

Selective acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor (IC 50 = 0.073 μ M). Lowers non-high density lipoprotein (HDL)-cholesterol and increases HDL-cholesterol concentrations in rats with pre-established dyslipidaemia. Orally active.

Biochem/physiol Actions

CI-976 (2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide), a new trimethoxy fatty acid anilide, is a potent and specific inhibitor of liver and intestinal acyl coenzyme A; cholesterol acyltransferase (ACAT) in vitro. CI-976 decreased non-high density lipoprotein (HDL)-cholesterol and increased HDL-cholesterol in rats with pre-established dyslipidemia. High performance gel chromatographic separation of plasma lipoproteins also revealed that CI-976, but not CL 277,082, lowered low density lipoprotein (LDL)-cholesterol and elevated HDL-cholesterol.

2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide Preparation Products And Raw materials

Raw materials

Preparation Products

2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide Suppliers

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CLEARSYNTH LABS LTD. 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 58
TargetMol Chemicals Inc. 58
Career Henan Chemica Co 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
Jilin Chinese Academy of Sciences-yanshen Technology 58
Aladdin Scientific 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 58
Suzhou Haiben Pharmaceutical Co., Ltd 58

114289-47-3(2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide)Related Search:

Dodecanamide N-(2,6-DIMETHOXYPHENYL)ACETAMIDE 2,4,6-TRIMETHOXYANILINE 2,6-DIMETHOXYANILINE BUTYL-(2,4-DIMETHOXY-PHENYL)-AMINE
3,5-DIMETHOXY-2-AMINO-PHENOL 2,6-DIMETHOXY-N-PROPYLBENZENAMINE 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
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2,2-dimethyl-n-(2,4,6-trimethoxyphenyl)-dodecanamid 2,2-DIMETHYL-N-(2,4,6-TRIMETHOXYPHENYL)DODECANAMIDE CI 976 PD 128042 N-(2,4,6-Trimethoxyphenyl)-2,2-dimethyldodecanamide CI-976 (PD 128042) Dodecanamide, 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)- inhibit,oral,PD128042,PD 128042,CI-976,Diacylglycerol acyltransferase,PD-128042,Acyltransferase,transferase,secretory,LPAT,acyl-CoA:cholesterol acyltransferase,mono- acylglycerol acyltransferase,endocytic membrane trafficking pathway,ACAT,CI976,Diglyceride acyltransferase,Inhibitor 114289-47-3 Miscellaneous Compounds Selective acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor.