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ChemicalBook > Product Catalog >Biochemical Engineering >Amino Acids and Derivatives >Lysine derivatives >Fmoc-Lys(Ddiv)-OH

Fmoc-Lys(Ddiv)-OH

Fmoc-Lys(Ddiv)-OH Structure
CAS No.
204777-78-6
Chemical Name:
Fmoc-Lys(Ddiv)-OH
Synonyms
Fmoc-Lys(Ddiv)-OH;FMOC-LYS(IVDDE)-OH;Fmoc-Lys(ivDde)-0H;Fmoc-Lys(iVDdde)-OH;FMOC-L-LYS(IVDDE)-OH;FMOC-LYSINE(IVDDE)-OH;FMOC-LYS(IVDDE)-OH 5 G;FMoc-Lys(Ddiv)-OHFMoc-Ly;FMOC-LYS(IVDDE)-OH USP/EP/BP;Fmoc-Lys(ivDde)-OH Novabiochem
CBNumber:
CB9168561
Molecular Formula:
C34H42N2O6
Molecular Weight:
574.71
MOL File:
204777-78-6.mol
Modify Date:
2024/3/5 16:46:33
Request For Quotation

Fmoc-Lys(Ddiv)-OH Properties

Boiling point 765.6±60.0 °C(Predicted)
Density 1.183±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka 3.88±0.21(Predicted)
form Powder
color White
InChIKey PYCBVLUBTMHNPW-MHZLTWQESA-N
SMILES C(O)(=O)[C@H](CCCCN/C(=C1/C(=O)CC(C)(C)CC/1=O)/CC(C)C)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H312-H332
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501
WGK Germany  3
F  10-21
HS Code  2924 29 70

Fmoc-Lys(Ddiv)-OH price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 8.52082 Fmoc-Lys(ivDde)-OH Novabiochem? 204777-78-6 1G ₹13880 2022-06-14 Buy
Sigma-Aldrich(India) 8.52082 Fmoc-Lys(ivDde)-OH Novabiochem? 204777-78-6 5G ₹55330 2022-06-14 Buy
Sigma-Aldrich(India) 8.52082 Fmoc-Lys(ivDde)-OH Novabiochem? 204777-78-6 8520820025 ₹123560 2022-06-14 Buy
Sigma-Aldrich(India) 8.52082 Fmoc-Lys(ivDde)-OH Novabiochem? 204777-78-6 8520820100 ₹265710 2022-06-14 Buy
Sigma-Aldrich(India) 8.52082 Fmoc-Lys(ivDde)-OH Novabiochem? 204777-78-6 8520820500 ₹1298370 2022-06-14 Buy
Product number Packaging Price Buy
8.52082 1G ₹13880 Buy
8.52082 5G ₹55330 Buy
8.52082 8520820025 ₹123560 Buy
8.52082 8520820100 ₹265710 Buy
8.52082 8520820500 ₹1298370 Buy

Fmoc-Lys(Ddiv)-OH Chemical Properties,Uses,Production

Description

Fmoc-lys(IVDDE)-OH is a kind of FMOC (9H-fluoren-9-ylmethoxycarbon) and N-IVDDE (1-(4,4-Dimethyl-2,6-dioxo-cyclohexylidene)-3-methyl-butyl) double protected amino acid (lysine). It is important during peptide manufacturing. It is mainly used for the production of peptides which required to be modified on the Lysine side chain, including peptides labeled peptides, PEGylated peptides or peptides cyclized through the Lys side chain. It can also be used for the manufacturing of anionic cell penetrating peptide which is useful for intracellular delivery of therapeutic agents such as proteins and nucleic acids. The IVDDE group can be conveniently removed thorough hydrazine in the presence of acid labile groups.

Chemical Properties

White to pale yellow powder

Uses

Fmoc-Lys(ivDde)-OH is especially useful for preparing peptides selectively modified on the Lys sidechain, such as peptides labeled peptides, PEGylated peptides or peptides cyclized through the Lys sidechain. The ivDde protective group possesses higher orthogonality regarding Boc and Fmoc in comparison to Dde. The ivDde group can be selectively removed with hydrazine in the presence of acid labile groups such as t-butyl and trityl based protecting groups.

Advantages

Fmoc-Lys(ivDde)-OH could be used to synthesize hetero-branched peptidesto avoid homodimer generation and construct heterodimers with a high ratio. This agent was used to generate Cellpenetrating peptides (CPP) and candidate peptides in one molecule[1].

References

Wen-Qu, L. I., X. U. Hong-Yan, and L. I. Zhan-Xiong. "Synthesis of End N-Ivdde Protected Amino Acid."Chinese Journal of Synthetic Chemistry 17.2(2009):213-215.
http://www.chempep.com/ChemPep_Products2_Fmoc-Amino-Acid.php?id=101224
Chen, Hui Ting, et al. "Anionic cell penetrating peptide and its use for intracellular delivery." US, US8614194. 2013.
[1] Kozaki L, et al. Disulfide linked hetero dimeric peptide arrays for screening functional peptides inside cells. Journal of Bioscience and Bioengineering, 2019; 129: 613-618.

Fmoc-Lys(Ddiv)-OH Preparation Products And Raw materials

Raw materials

2-(3-METHYLBUTYRYL)-5,5-DIMETHYL-1,3-CYCLOHEXANDIONE Isovaleric acid FMOC-LYS-OH

Preparation Products

Fmoc-Lys(Ddiv)-OH Suppliers

Global( 213)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
JSK Chemicals +919879767970 Gujarat, India 3756 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Otto Chemie Pvt. Ltd. +91 9820041841 Mumbai, India 5873 58 Inquiry
Alpha Biopharmaceuticals Co., Ltd +86-15542445688 China 888 58 Inquiry
Sichuan HongRi Pharma-Tech Co.,Ltd +86-028-64841719 +8617390183901 China 1106 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
Shanghai Daken Advanced Materials Co.,Ltd +86-371-66670886 China 16209 58 Inquiry
Hangzhou FandaChem Co.,Ltd. 008657128800458; +8615858145714 China 9337 55 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29898 58 Inquiry
Supplier Advantage
JSK Chemicals 58
A.J Chemicals 58
Otto Chemie Pvt. Ltd. 58
Alpha Biopharmaceuticals Co., Ltd 58
Sichuan HongRi Pharma-Tech Co.,Ltd 58
Capot Chemical Co.,Ltd. 60
Shanghai Daken Advanced Materials Co.,Ltd 58
Hangzhou FandaChem Co.,Ltd. 55
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58

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Fmoc-Lys(Ddiv)-OH Spectrum

FMOC-LYS(IVDDE)-OH(204777-78-6)1HNMR

204777-78-6(Fmoc-Lys(Ddiv)-OH)Related Search:

Fmoc-L-Lys(Dde)-OH (s)-3-(fmoc-amino)-n-trityl-adipic acid 6-amide FMoc-Lys-AMC.HCl FMOC-L-LYS(DANSYL)-OH Fmoc-Lys(N3)-OH
FMoc-Aea-OH N(ALPHA)-FMOC-N(EPSILON)-DABCYL-L-LYSINE FMOC-LYS(BOC)(ME)-OH FMOC-LYS(ME)2-OH HCL FMOC-LYS(DNP)-OH
Fmoc-Lys(Trt)-OH FMOC-LYS(ME3)-OH HCL N-Boc-N'-Fmoc-L-Lysine L-Fmoc-Aspartic acid alpha-tert-butyl ester N-Boc-N'-Fmoc-D-lysine
FMOC-D-ASP-OTBU FMOC-D-GLU-OTBU FMOC-D-LYS(IVDDE)-OH
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FMoc-Lys(ivDde)-OH N-α-FMoc-N-ε-1-(4,4-diMethyl-2,6-dioxocyclohex-1 -ylidene)-3-Methylbutyl-L-lysine Fmoc-Lys(Ddiv)-OH (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-6-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutylamino)hexanoic acid Nα-Fmoc-Nε-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-lysine≥ 99.9% (HPLC, Chiral purity) Fmoc-Lys(ivDde)-OH Novabiochem Nalpha-Fmoc-Nepsilon-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]-L-lysine FMOC-N-EPSILON-1-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEX-1-YLIDENE)-3-METHYLBUTYL-L-LYSINE FMOC-LYSINE(IVDDE)-OH FMOC-LYS(IVDDE)-OH FMOC-L-LYS(IVDDE)-OH N-α-Fmoc-N-ε-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-lysine FMoc-Lys(Ddiv)-OHFMoc-Ly N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-EPSILON-[1-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEX-1-YLIDENE)-3-METHYLBUTYL]-L-LYSINE N-ALPHA-(9-FLUORENYL)METHOXYCARBONYL)-N-EPSILON-[1-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEXYLIDENE-3-METHYLBUTYL]-L-LYSINE N-ALPHA-FMOC-N-EPSILON-1-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEX-1-YLIDENE)-3-METHYLBUTYL-L-LYSINE (2S)-6-{[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanoic acid Fmoc-Lys(ivDde)-0H (9H-Fluoren-9-yl)MethOxy]Carbonyl L-Lys(ivDde)-OH FMOC-LYS(IVDDE)-OH 5 G N~6~-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]-N~2~-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-lysine L-Lysine, N6-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]- (2S)-6-[[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoicaci FMOC-LYS(IVDDE)-OH USP/EP/BP Nα-Fmoc-Nε-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-lysine N~6~-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbuty... Fmoc-Lys(ivDde)-OH, ≥96% (HPLC) N6-[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]-N2-Fmoc-L-lysine Fmoc-Lys(iVDdde)-OH 204777-78-6 204777-78-4 C34H42N2O6 Lysine Specialty Synthesis Peptide Synthesis Amino Acid Derivatives amino acids amino acid