(S)-3-Hydroxypyrrolidine
- CAS No.
- 100243-39-8
- Chemical Name:
- (S)-3-Hydroxypyrrolidine
- Synonyms
- (S)-PYRROLIDIN-3-OL;S-HP;(S)-3-PyrroL;(S)-3-PYRROLIDINOL;(+)-3-Pyrrolidinol;3-PYRROLIDINOL, (S);(3S)-3-Pyrrolidinol;(S)-Pyrrolidine-3-ol;(3S)-Pyrrolidin-3-ol;(3S)-Pyrrolidine-3-ol
- CBNumber:
- CB9195781
- Molecular Formula:
- C4H9NO
- Molecular Weight:
- 87.12
- MOL File:
- 100243-39-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
| Melting point | 15°C |
|---|---|
| Boiling point | 108-110 °C (8 mmHg) |
| alpha | -6.5 º (c=3.5% in MeOH) |
| Density | 1.078 g/mL at 20 °C (lit.) |
| refractive index |
n |
| Flash point | >110°C |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 14.91±0.20(Predicted) |
| form | Liquid After Melting |
| color | Clear light yellow to yellow |
| Specific Gravity | 1.078 |
| optical activity | [α]20/D 6.5±1.5°, c = 3.5% in methanol |
| Water Solubility | Fully miscible in water. |
| Sensitive | Air Sensitive & Hygroscopic |
| BRN | 4652606 |
| CAS DataBase Reference | 100243-39-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-40 | |||||||||
| Safety Statements | 26-37/39-36-22 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-34 | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
(S)-3-Hydroxypyrrolidine price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 56437 | (S)-3-Pyrrolidinol ≥97.0% (sum of enantiomers, GC) | 100243-39-8 | 1ML | ₹11561.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 56437 | (S)-3-Pyrrolidinol ≥97.0% (sum of enantiomers, GC) | 100243-39-8 | 5ML | ₹45400.05 | 2022-06-14 | Buy |
| TCI Chemicals (India) | P1667 | (S)-3-Pyrrolidinol min. 97.0 % | 100243-39-8 | 1G | ₹4600 | 2022-05-26 | Buy |
| TCI Chemicals (India) | P1667 | (S)-3-Pyrrolidinol min. 97.0 % | 100243-39-8 | 5G | ₹11900 | 2022-05-26 | Buy |
| TCI Chemicals (India) | P1667 | (S)-3-Pyrrolidinol min. 97.0 % | 100243-39-8 | 25G | ₹40700 | 2022-05-26 | Buy |
(S)-3-Hydroxypyrrolidine Chemical Properties,Uses,Production
Description
(S)-3-Hydroxypyrrolidine is a chiral organic compound that serves as an important building block in the synthesis of various pharmaceuticals and natural products. It is a four-membered heterocyclic amino alcohol, featuring a hydroxyl group and a stereogenic center. The 'S' prefix indicates the configuration at the stereocenter, which is crucial for its reactivity and biological activity. This compound is notable for its role as an intermediate in the synthesis of drugs, particularly those targeting the central nervous system. The enantiomeric purity of (S)-3-Hydroxypyrrolidine is often critical, as the 'R' and 'S' enantiomers can exhibit different pharmacological properties.
Chemical Properties
clear light yellow to yellow liquid after melting
Uses
(S)-(-)-3-Hydroxypyrrolidine is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields.
Purification Methods
The (±)-isomer is purified by repeated distillation ( b 102-104o/12mm, 108-110o/18mm), and the (±)-picrate crystallises from EtOH with m 140-141o. The R(+)-enantiomer has b 70o/0.6mm and [] D +5.6o (c 3.63, MeOH). Its hydrochloride has a negative rotation and its dimethiodide has m 230o and [] 24 -8.02o. [Suyama & Kanno Yakugaku Zasshi (J Pharm Soc Japan) 85 531 1965, Uno et al. J Heterocycl Chem 24 1025 1987, Flanagan & Joullie Heterocycles 26 2247 1987, Beilstein 21 III/IV 44.]
(S)-3-Hydroxypyrrolidine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Tulasi Labs | +91-8106722317 +91-8106722317 | Telangana, India | 44 | 58 | Inquiry |
| Chemphora life sciences | +91-9849979989 +91-9849979989 | Hyderabad, India | 326 | 58 | Inquiry |
| ARRKEM LIFE SCIENCES PRIVATE LIMITED | +91-8148739767 +91-8148739767 | Telangana, India | 347 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6905 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6700 | 30 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| VASIN BIO LIFE SCIENCES PVT LTD | 9491644688 | Hyderabad, India | 2092 | 58 | Inquiry |
| Vyas Bio Life Sciences Pvt. Ltd | -65546373 | Hyderabad, India | 1213 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Tulasi Labs | 58 |
| Chemphora life sciences | 58 |
| ARRKEM LIFE SCIENCES PRIVATE LIMITED | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| A.J Chemicals | 58 |
| CHEMSWORTH | 30 |
| CLEARSYNTH LABS LTD. | 58 |
| VASIN BIO LIFE SCIENCES PVT LTD | 58 |
| Vyas Bio Life Sciences Pvt. Ltd | 58 |