Chinese english Japanese Germany Korea
ChemicalBook > Product Catalog >Pharmaceutical intermediates >(S)-1-Boc-2-(Hydroxymethyl)piperazine

(S)-1-Boc-2-(Hydroxymethyl)piperazine

(S)-1-Boc-2-(Hydroxymethyl)piperazine Structure
CAS No.
1030377-21-9
Chemical Name:
(S)-1-Boc-2-(Hydroxymethyl)piperazine
Synonyms
(S)-1-Boc-2-(hyroxyMethyl)piperazine;(S)-1-N-BOC-2-HYDROXYMETHYLPIPERAZINE;(S)-N1-BOC-2-Hydroxymethyl-piperazine;(2S)-2-(Hydroxymethyl)piperazine, N1-BOC protected;(S)-tert-butyl 2-(hydroxyMethyl)piperazin-1-carboxylate;(S)-tert-butyl 2-(hydroxyMethyl)piperazine-1-carboxylate;tert-butyl (S)-2-(hydroxymethyl)piperazine-1-carboxylate;tert-butyl (2S)-2-(hydroxymethyl)piperazine-1-carboxylate;1,1-Dimethylethyl (2S)-2-(hydroxymethyl)-1-piperazinecarboxylate;(S)-2-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CBNumber:
CB9233339
Molecular Formula:
C10H20N2O3
Molecular Weight:
216.28
MOL File:
Mol file
Modify Date:
2023/10/19 9:29:34
Request For Quotation

(S)-1-Boc-2-(Hydroxymethyl)piperazine Properties

Boiling point 324℃
Density 1.085
Flash point 150℃
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka 14.97±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2933599590

(S)-1-Boc-2-(Hydroxymethyl)piperazine Chemical Properties,Uses,Production

Reactions

(S)-1-Boc-2-(Hydroxymethyl)piperazine reacts with 1,2-difluoro-4-nitrobenzene to synthesize tert-butyl (S)-4-(2-fluoro-4-nitrophenyl)-2-(hydroxymethyl)piperazine-1-carboxylate. This compound serves as a crucial intermediate in the preparation of the Wee-1 kinase activity inhibitor.
(S)-1-Boc-2-(Hydroxymethyl)piperazine

Synthesis

To a solution of (S)-4-benzyl 1-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate (1.5 g, 4.28 mmol) in MeOH (20 mL), 10 % Pd/C (150 mg) was added. The mixture was stirred at room temperature for 3 hours under H2. Afterwards, the solid was removed by filtration and the filtrate was concentrated to yield (S)-1-Boc-2-(Hydroxymethyl)piperazine (850 mg, 3.93 mmol, 91.82 percent) as a white solid.
undefined

(S)-1-Boc-2-(Hydroxymethyl)piperazine Preparation Products And Raw materials

Raw materials

1,4-Piperazinedicarboxylic acid, 2-(hydroxymethyl)-, 1-(1,1-dimethylethyl) 4-(phenylmethyl) ester, (2S)-

Preparation Products

(S)-1-Boc-2-(Hydroxymethyl)piperazine Suppliers

Global( 108)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Shanghai Boc Chemical Co., Ltd. 021-34975602; +8618721111801 China 138 58 Inquiry
Hangzhou FandaChem Co.,Ltd. 008657128800458; +8615858145714 China 9338 55 Inquiry
Jinan Carbotang Biotech Co.,Ltd. +8615866703830 China 7287 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd +8613580539051 CHINA 21149 58 Inquiry
SIMAGCHEM CORP +86-13806087780 China 17367 58 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30253 58 Inquiry
Blocksynth Pharmaceutical Technology Co.,Ltd 0086-19817745290; +8619817745290 China 5660 58 Inquiry
Supplier Advantage
A.J Chemicals 58
Shanghai Boc Chemical Co., Ltd. 58
Hangzhou FandaChem Co.,Ltd. 55
Jinan Carbotang Biotech Co.,Ltd. 58
CONIER CHEM AND PHARMA LIMITED 58
career henan chemical co 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 58
SIMAGCHEM CORP 58
Career Henan Chemica Co 58
Blocksynth Pharmaceutical Technology Co.,Ltd 58

(S)-1-Boc-2-(Hydroxymethyl)piperazine Spectrum

(S)-2-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(1030377-21-9)1HNMR

1030377-21-9((S)-1-Boc-2-(Hydroxymethyl)piperazine)Related Search:

(R)-1-Boc-4-benzyl-2-(hydroxymethyl)piperazine tert-butyl (S)-2-(aminomethyl)-4,4-dimethylpyrrolidine-1-carboxylate (S)-2-Hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester (R)-tert-Butyl 3-(methoxymethyl)piperazine-1-carboxylate (R)-1-N-Boc-2-(hydroxymethyl)piperazine
(R)-4-benzyl-2-hydroxymethylpiperazine (S)-1-Boc-4-benzyl-2-(hydroxymethyl)piperazine (S)-4-benzyl-2-hydroxymethylpiperazine (S)-tert-butyl 2-(MethoxyMethyl)piperazine-1-carboxylate (S)-1-N-BOC-2-METHOXYMETHYLPIPERAZINE
(S)-N-Boc-2-Hydroxymethylmorpholine (S)-N-Boc-2-aminomethylmorpholine tert-butyl (2R)-2-(MethoxyMethyl)piperazine-1-carboxylate tert-butyl (S)-2-(aminomethyl)-5-bromoindoline-1-carboxylate tert-butyl (S)-2-(aminomethyl)-4,4-difluoropiperidine-1-carboxylate
(S)-1-N-Boc-piperazine-2-carboxylic acid methyl ester (S)-1-N-BOC-4-N-FMOC-PIPERAZINE-2-CARBOXYLIC ACID (S)-N-1-Boc-N-4-Cbz-2-piperazine carboxylic acid
chevron_left

1of4

chevron_right
(2S)-2-(Hydroxymethyl)piperazine, N1-BOC protected tert-Butyl (2S)-2-(hydroxymethyl)piperazine-1-carboxylate, (2S)-1-(tert-Butoxycarbonyl)-2-(hydroxymethyl)piperazine tert-butyl (S)-2-(hydroxymethyl)piperazine-1-carboxylate tert-butyl (2S)-2-(hydroxymethyl)piperazine-1-carboxylate (S)-2-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (S)-1-N-BOC-2-HYDROXYMETHYLPIPERAZINE 1-PIPERAZINECARBOXYLIC ACID, 2-(HYDROXYMETHYL)-, 1,1-DIMETHYLETHYL ESTER, (2S)- (S)-tert-butyl 2-(hydroxyMethyl)piperazin-1-carboxylate (S)-tert-butyl 2-(hydroxyMethyl)piperazine-1-carboxylate (S)-1-Boc-2-(hyroxyMethyl)piperazine 1,1-Dimethylethyl (2S)-2-(hydroxymethyl)-1-piperazinecarboxylate (2S)-2-(hydroxymethyl)-1-Piperazinecarboxylic acid tert-butyl ester (S)-N1-BOC-2-Hydroxymethyl-piperazine 1030377-21-9