2-하이드록시메틸-피페라진
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2-하이드록시메틸-피페라진 속성
- 끓는 점
- 324℃
- 밀도
- 1.085
- 인화점
- 150℃
- 저장 조건
- under inert gas (nitrogen or Argon) at 2–8 °C
- 산도 계수 (pKa)
- 14.97±0.10(Predicted)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| HS 번호 | 2933599590 |
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| 그림문자(GHS): |
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| 신호 어: | Warning | ||||||||||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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2-하이드록시메틸-피페라진 C화학적 특성, 용도, 생산
화학 반응
(S)-1-Boc-2-(Hydroxymethyl)piperazine reacts with 1,2-difluoro-4-nitrobenzene to synthesize tert-butyl (S)-4-(2-fluoro-4-nitrophenyl)-2-(hydroxymethyl)piperazine-1-carboxylate. This compound serves as a crucial intermediate in the preparation of the Wee-1 kinase activity inhibitor.
Synthesis
To a solution of (S)-4-benzyl 1-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate (1.5 g, 4.28 mmol) in MeOH (20 mL), 10 % Pd/C (150 mg) was added. The mixture was stirred at room temperature for 3 hours under H2. Afterwards, the solid was removed by filtration and the filtrate was concentrated to yield (S)-1-Boc-2-(Hydroxymethyl)piperazine (850 mg, 3.93 mmol, 91.82 percent) as a white solid.
2-하이드록시메틸-피페라진 준비 용품 및 원자재
원자재
준비 용품
2-하이드록시메틸-피페라진 공급 업체
글로벌( 108)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Shanghai Boc Chemical Co., Ltd. | 021-34975602; +8618721111801 |
shangli@bocchem.com | China | 138 | 58 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9338 | 55 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 |
figo.gao@foxmail.com | China | 7287 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 |
info@accelachem.com | United States | 19965 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49391 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29826 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 |
joe@yuhengpharm.com | CHINA | 21149 | 58 |
| SIMAGCHEM CORP | +86-13806087780 |
sale@simagchem.com | China | 17367 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 |
laboratory@coreychem.com | China | 30253 | 58 |
2-하이드록시메틸-피페라진 관련 검색:
(R)-1-Boc-4-benzyl-2-(hydroxymethyl)piperazine
tert-butyl (S)-2-(aminomethyl)-4,4-dimethylpyrrolidine-1-carboxylate
(S)-2-Hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester
(R)-tert-Butyl 3-(methoxymethyl)piperazine-1-carboxylate
(R)-1-N-Boc-2-(hydroxymethyl)piperazine
(R)-4-benzyl-2-hydroxymethylpiperazine
(S)-1-Boc-4-benzyl-2-(hydroxymethyl)piperazine
(S)-4-benzyl-2-hydroxymethylpiperazine
(S)-tert-butyl 2-(MethoxyMethyl)piperazine-1-carboxylate
(S)-1-N-BOC-2-METHOXYMETHYLPIPERAZINE
(S)-N-Boc-2-Hydroxymethylmorpholine
(S)-N-Boc-2-aminomethylmorpholine
tert-butyl (2R)-2-(MethoxyMethyl)piperazine-1-carboxylate
tert-butyl (S)-2-(aminomethyl)-5-bromoindoline-1-carboxylate
tert-butyl (S)-2-(aminomethyl)-4,4-difluoropiperidine-1-carboxylate
(S)-1-N-Boc-piperazine-2-carboxylic acid methyl ester
(S)-1-N-BOC-4-N-FMOC-PIPERAZINE-2-CARBOXYLIC ACID
(S)-N-1-Boc-N-4-Cbz-2-piperazine carboxylic acid