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5-Amino-3-phenyl-1,2,4-thiadiazole

5-Amino-3-phenyl-1,2,4-thiadiazole Structure
CAS No.
17467-15-1
Chemical Name:
5-Amino-3-phenyl-1,2,4-thiadiazole
Synonyms
NSC 119930;TIMTEC-BB SBB005511;2-methyl-2-oxolanamine;4-thiadiazol-5-amine,3-phenyl-2;3-Phenyl-1,2,4-triazol-5-ylamine;3-PHENYL-1,2,4-THIADIAZOL-5-AMINE;5-Amino-3-phenyl-1,2,4-thidiazole;5-AMINO-3-PHENYL-1,2,4-THIADIAZOLE;5-Amino-3-plenyl-1,2,4-thiadiazole;2-amino-4-phenyl-1,3,5-thiadiazole
CBNumber:
CB9253759
Molecular Formula:
C8H7N3S
Molecular Weight:
177.23
MOL File:
17467-15-1.mol
Modify Date:
2024/5/29 15:30:41

5-Amino-3-phenyl-1,2,4-thiadiazole Properties

Melting point 152-156 °C
Density 1.2353 (rough estimate)
refractive index 1.5700 (estimate)
storage temp. 2-8°C
form powder
color White
InChI InChI=1S/C8H7N3S/c9-8-10-7(11-12-8)6-4-2-1-3-5-6/h1-5H,(H2,9,10,11)
InChIKey OYAHSBDYBOBAAQ-UHFFFAOYSA-N
SMILES S1C(N)=NC(C2=CC=CC=C2)=N1
CAS DataBase Reference 17467-15-1(CAS DataBase Reference)
EPA Substance Registry System 1,2,4-Thiadiazol-5-amine, 3-phenyl- (17467-15-1)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P301+P312-P302+P352-P304+P340-P305+P351+P338
Hazard Codes  Xn,Xi
Risk Statements  36/37/38-20/21/22-41-22
Safety Statements  36/37/39-26-22
HazardClass  IRRITANT
HS Code  29341000

5-Amino-3-phenyl-1,2,4-thiadiazole Chemical Properties,Uses,Production

Description

5-Amino-3-phenyl-1,2,4-thiadiazole is an important organic synthetic reagent with remarkable reactivity and stability and has been used in the synthesis of a variety of heterocyclic compounds including 1,2,4-triazol-3-ylphenyls, derivatives of 2-aryl-5-amino-thiadiazole, 5-amino-1,2,4-thiadiazol-3-phenyls, and 5 -amino-1,2,4-thiadiazole-3-phenyl-3-methyl derivatives. It is also used in the synthesis of polymers such as poly(5-amino-3-phenyl-1,2,4-thiadiazole). In addition, 5-amino-3-phenyl-1,2,4-thiadiazole is an inhibitor of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX). The compound inhibits the release of pro-inflammatory cytokines such as tumour necrosis factor-α (TNF-α) and interleukin-1β (IL-1β).

Chemical Properties

LIGHT BROWNISH FINE CRYSTALLINE POWDER

Uses

3-Phenyl-1,2,4-thiadiazol-5-amine is used as a reactant in the preparation of thiazole and thiadiazole derivatives as potent and selective human adenosine A3 receptor antagonists.

5-Amino-3-phenyl-1,2,4-thiadiazole Preparation Products And Raw materials

Raw materials

Preparation Products

5-Amino-3-phenyl-1,2,4-thiadiazole Suppliers

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NSC 119930 3-phenyl-1,2,4-thiadiazol-5-ylamine 3-Phenyl-1,2,4-triazol-5-ylamine 5-AMINO-3-PHENYL-1,2,4-THIADIAZOLE 99% 5-Amino-3-phenyl-1,2,4-thiadiazole,99% 5-AMino-3-phenyl-1,2,4-thiadiazole, 99% 5GR 3-Phenyl-1,2,4-thiadiazol-5-aMine, >95% 4-thiadiazol-5-amine,3-phenyl-2 TIMTEC-BB SBB005511 5-AMINO-3-PHENYL-1,2,4-THIADIAZOLE 3-PHENYL-1,2,4-THIADIAZOL-5-AMINE 1,2,4-THIADIAZOL-5-AMINE, 3-PHENYL- 5-Amino-3-plenyl-1,2,4-thiadiazole 2-amino-4-phenyl-1,3,5-thiadiazole 2-methyl-2-oxolanamine 5-Amino-3-phenyl-1,2,4-thidiazole 17467-15-1