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Vorapaxar Sulfate

Vorapaxar Sulfate Structure
CAS No.
705260-08-8
Chemical Name:
Vorapaxar Sulfate
Synonyms
Zontivity;Sch 530348;Vorapaxar-d5;Vorapaxar Sulfate;SCH 530348 sulfate;SCH-530348;SCH530348;vorapaxar impurity A;vorapaxar monosulfate;Vorapaxar Sulfate API;Vorapaxar sulfate salt
CBNumber:
CB92545858
Molecular Formula:
C29H35FN2O8S
Molecular Weight:
590.66
MOL File:
705260-08-8.mol
Modify Date:
2024/10/10 8:28:32
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Vorapaxar Sulfate Properties

storage temp. 4°C, away from moisture
solubility DMSO : 125 mg/mL (211.63 mM; Need ultrasonic)| (insoluble)
form Solid
color White to off-white
Water Solubility Water : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H320-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

Vorapaxar Sulfate Chemical Properties,Uses,Production

Description

Merck Sharp & Dohme successfully obtained approval in the EU in 2014 for vorapaxar sulfate, marketed as Zontivity®. The drug is a first-in-class thrombin receptor (also referred to as a protease-activated or PAR-1) antagonist which, when used in conjunction with antiplatelet therapy, has been shown to reduce the chance of myocardial infarction and stroke, particularly in patients with a history of cardiac events. Antagonism of PAR-1 allows for thrombin-mediated fibrin deposition while blocking thrombinmediated platelet activation.

Uses

SCH-530348 is a novel antiplatelet agent undergoing development by Schering-Plough Corp for the treatment and prevention of atherothrombosis. acute coronary syndrome (unstable angina/non-ST segment elevation myocardial infarction) and secondary prevention of cardiovascular events in high-risk patients.

Definition

ChEBI: An organic sulfate salt obtained by combining vorapaxar with one molar equivalent of sulfuric acid. A protease-activated receptor-1 antagonist used for the reduction of thrombotic cardiovascular events in patients with a history of myocardial infarction (M ) or with peripheral arterial disease. It has been shown to reduce the rate of a combined endpoint of cardiovascular death, MI, stroke and urgent coronary revascularisation.

Vorapaxar Sulfate Preparation Products And Raw materials

Raw materials

Preparation Products

Vorapaxar Sulfate Suppliers

Global( 182)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. +86-18600796368 +86-18600796368 China 375 58 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21662 55 Inquiry
Hangzhou FandaChem Co.,Ltd. 008657128800458; +8615858145714 China 9240 55 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32835 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29899 58 Inquiry
Beijing Ribio Biotech Co.,Ltd 010-62664360 +8613328773880 China 117 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
SynZeal Research Pvt Ltd 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. 58
Henan Tianfu Chemical Co.,Ltd. 55
Hangzhou FandaChem Co.,Ltd. 55
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
Beijing Ribio Biotech Co.,Ltd 58
Chongqing Chemdad Co., Ltd 58

Vorapaxar Sulfate Spectrum

Vorapaxar Sulfate(705260-08-8)1HNMR

705260-08-8(Vorapaxar Sulfate)Related Search:

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Vonoprazan fumarate ethyl ((1R,3aR,4aR,6S,8aR,9S,9aS)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl)carbamate Phosphonic acid, [[5-(3-fluorophenyl)-2-pyridinyl]Methyl]-, diethyl ester Thrombin (3R,3aS,4S,4aS,7R,9aR)-3-Methyl-7-nitro-1-oxo-N,N-diphenyl-1,3,3a,4,4a,5,6,7,8,9a-decahydronaphtho[2,3-c]furan-4-carboxamide
Vorapaxar Vorapaxar (1R,3aR,4aR,8aR,9S,9aR)-1-methyl-3-oxodecahydro-3H-spiro[naphtho[2,3-c]furan-6,2'-[1,3]dioxolane]-9-carboxylic acid
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Vorapaxar Sulfate N-[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-Fluorophenyl)-2-pyridinyl]ethenyl]dodecahydro-1-Methyl-3-oxonaphtho[2,3-c]furan-6-yl]carbaMic Acid Ethyl Ester Sulfate Sch 530348 SCH 530348 (H2SO4 Salt) vorapaxar impurity A Carbamic acid, N-[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]-, ethyl ester, sulfate (1:1) SCH-530348;SCH530348 Vorapaxar Sulfate (SCH 530348) Vorapaxar-d5 SCH 530348 sulfate vorapaxar monosulfate Zontivity Vorapaxar sulfateQ: What is Vorapaxar sulfate Q: What is the CAS Number of Vorapaxar sulfate Q: What is the storage condition of Vorapaxar sulfate Q: What are the applications of Vorapaxar sulfate Vorapaxar Sulfate API Vorapaxar sulfate salt Ethyl ((1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl)carbamate sulfate 705260-08-8 C29H33FN2O4H2SO4 C29H35FN2O8S Aromatics Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals