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Vorapaxar

Vorapaxar Structure
CAS No.
618385-01-6
Chemical Name:
Vorapaxar
Synonyms
MK-5348;[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-Fluorophenyl)-2-pyridinyl]ethenyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]-carbamic acid ethyl ester;CS-2015;CS-1663;Vorapaxar;Voarapaxar;2H5]-Vorapaxar;7-Dihydrocapsaicin;Vorapaxar free base;Vorapaxar (MK-5348)
CBNumber:
CB32628522
Molecular Formula:
C29H33FN2O4
Molecular Weight:
492.58
MOL File:
618385-01-6.mol
Modify Date:
2024/7/2 8:55:06
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Vorapaxar Properties

Boiling point 676.0±55.0 °C(Predicted)
Density 1.24±0.1 g/cm3(Predicted)
storage temp. Store at -20° C
solubility ≥24.65 mg/mL in DMSO; insoluble in H2O; ≥10.64 mg/mL in EtOH with ultrasonic
form solid
pka 12.49±0.60(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08,GHS09
Signal word  Warning
Hazard statements  H371-H410-H373-H400
Precautionary statements  P273-P391-P501-P273-P391-P501-P260-P314-P501-P260-P264-P270-P309+P311-P405-P501
NFPA 704
0
2 0

Vorapaxar Chemical Properties,Uses,Production

Description

Vorapaxar is an orally bioavailable competitive antagonist of the proteinase-activated receptor (PAR1; Ki = 8.1 nM), also known as the thrombin receptor. It is selective for PAR1 over other PARs, as well as a number of GPCRs, ion channels, and receptors. It inhibits platelet aggregation induced by thrombin and haTRAP (IC50s = 47 and 25 nM, respectively). Vorapaxar (0.1 mg/kg, i.v.) completely inhibits platelet aggregation in cynomolgus monkeys ex vivo. Formulations containing vorapaxar are used in the prevention of thrombotic cardiovascular events.

Definition

ChEBI: A carbamate ester that is the ethyl ester of [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethyny }-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamic acid. A protease-activated receptor-1 antagonist used (as its sulfate salt) for the reduction of thrombotic cardiovascular events in patients with a history of myocardial infarction MI) or with peripheral arterial disease. It has been shown to reduce the rate of a combined endpoint of cardiovascular death, MI, stroke and urgent coronary revascularisation.

Vorapaxar Preparation Products And Raw materials

Raw materials

Preparation Products

Vorapaxar Suppliers

Global( 137)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21669 55 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29898 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
AFINE CHEMICALS LIMITED +86-0571-85134551 China 15395 58 Inquiry
XI'AN TIANGUANGYUAN BIOTECH CO., LTD. +86-029-86333380 18829239519 China 918 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Henan Tianfu Chemical Co.,Ltd. 55
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
BOC Sciences 58
Chongqing Chemdad Co., Ltd 58
AFINE CHEMICALS LIMITED 58
XI'AN TIANGUANGYUAN BIOTECH CO., LTD. 58
Zhejiang J&C Biological Technology Co.,Limited 58

Vorapaxar Spectrum

Vorapaxar(618385-01-6)1HNMR

618385-01-6(Vorapaxar)Related Search:

vorapaxar sulfate M-9 GS9857 Voreloxin PVM/MA Panipenem
Pazopanib LCZ696 RANAKININ Cilostazol (3R,3aS,4S,4aS,7R,9aR)-3-Methyl-7-nitro-1-oxo-N,N-diphenyl-1,3,3a,4,4a,5,6,7,8,9a-decahydronaphtho[2,3-c]furan-4-carboxamide
Vorapaxar Sulfate Vorapaxar (1R,3aR,4aR,8aR,9S,9aR)-1-methyl-3-oxodecahydro-3H-spiro[naphtho[2,3-c]furan-6,2'-[1,3]dioxolane]-9-carboxylic acid
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Vorapaxar Vorapaxar (SCH 530348) Voarapaxar Ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)-2-pyridinyl]vinyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamate [(1R,3AR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]dodecahydro-1-me Carbamic acid, N-[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]-, ethyl ester CS-1663 CS-2015 ethyl((1R,3aR,4aR,8aR,9aS)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl)carbamate Vorapaxar D5Q: What is Vorapaxar D5 Q: What is the CAS Number of Vorapaxar D5 Q: What is the storage condition of Vorapaxar D5 Q: What are the applications of Vorapaxar D5 TIANFUCHEM--618385-01-6--Vorapaxar 7-Dihydrocapsaicin [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-Fluorophenyl)-2-pyridinyl]ethenyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]-carbamic acid ethyl ester MK-5348 Vorapaxar free base 2H5]-Vorapaxar Vorapaxar (MK-5348) 618385-01-6 C29H33FN2O4 API