Panipenem
- CAS No.
- 87726-17-8
- Chemical Name:
- Panipenem
- Synonyms
- PAPM;cs533;PANIPENEM;Panipenan;Panipenemum;carbapenemrs-533;FAROPENEM, 90.0%;Panipenem USP/EP/BP;(5r-(3(s*),5-alpha,6-alpha(r*)))-inoethyl)-3-pyrrolidinyl)thio)-7-oxo;6-(1-hydroxyethyl)-2-(1-acetimidoylpyrrolidin-3-ylthio)-1-carbaren-2-em-3-ca
- CBNumber:
- CB1728204
- Molecular Formula:
- C15H21N3O4S
- Molecular Weight:
- 339.41
- MOL File:
- 87726-17-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/4 17:34:43
| Melting point | 198-200° (dec) |
|---|---|
| Boiling point | 555.5±60.0 °C(Predicted) |
| Density | 1.62±0.1 g/cm3(Predicted) |
| storage temp. | Amber Vial, Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Very Slightly), Water (Slightly) |
| pka | 4.30±0.40(Predicted) |
| form | Solid |
| color | White to Off-White |
| Stability | Hygroscopic, Light Sensitive |
| CAS DataBase Reference | 87726-17-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
| Toxicity | Approx LD50 in male, female mice (mg/kg): 1700-2200, 1300-1700 i.v. (Kimura) |
Panipenem Chemical Properties,Uses,Production
Uses
Panipenem is a broad spectrum carbapenem antibacterial and antimicrobial agent working against Gram-negative and Gram-positive organisms.
Antimicrobial activity
A 3-acetimidoylpyrrolidinyl-substituted carbapenem with
no methyl group at the C-1 position. It has broad-spectrum
antibacterial activity against Gram-positive and Gramnegative
organisms very similar to that of other carbapenems.
Activity against Ps. aeruginosa is similar to that of imipenem.
It is co-administered in a ratio of 1:1 with betamipron
(N-benzoyl-β-alanine), a renal anion transport inhibitor that
decreases nephrotoxicity. Panipenem is slightly more stable
to hydrolysis by dehydropeptidase than imipenem, but not
as stable as meropenem or biapenem. It is hydrolyzed by
carbapenemases.
Mean maximum blood concentrations following intravenous
infusion of 0.5 g and 0.75 g of each component
were 37 and 61 mg/L for panipenem and 24 and 39 mg/L
for betamipron. Following intravenous infusion in children
(10 mg or 20 mg of each component per kg), the half-life
of panipenem was about 1.2 h; that of betamipron about
0.9 h. Drug levels in the CSF were at least eight-fold lower
than serum concentrations.
Side effects are similar to those reported for other carbapenems
(incidence <10%) and are generally mild. Patients
with a history of previous hypersensitivity reactions to penicillins,
cephalosporins or other β-lactam antibiotics should be
treated cautiously.
Clinical use in serious infections is similar to that of other
carbapenems.
Panipenem Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Honour Lab Limited | +919845977466 | Telangana, India | 164 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21676 | 55 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29901 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | China | 2132 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | China | 9030 | 58 | Inquiry |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | China | 15395 | 58 | Inquiry |
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