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ChemicalBook > Product Catalog >API >Synthetic Anti-infective Drugs >Quinolones >Pefloxacin

Pefloxacin

Pefloxacin Structure
CAS No.
70458-92-3
Chemical Name:
Pefloxacin
Synonyms
PEFLOXACIN METHANESULFONATE;PEFLOXACIN MESYLATE DIHYDRATE;pefloxacine;1-Ethyl-4-oxo-6-fluoro-7-(4-methyl-1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid;am725;1584rb;am-725;1589RB;RB-1589;EU-5306
CBNumber:
CB2304155
Molecular Formula:
C17H20FN3O3
Molecular Weight:
333.36
MOL File:
70458-92-3.mol
Modify Date:
2024/7/24 17:31:20
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Pefloxacin Properties

Melting point 270-272° (dec)
Boiling point 529.1±50.0 °C(Predicted)
Density 1.320±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Aqueous Acid (Slightly), Methanol (Slightly), Water (Slightly)
form Solid
pka 0.16±0.20(Predicted)
color White to Off-White
CAS DataBase Reference 70458-92-3(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P321-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501
Toxicity LD50 in mice (mg/kg): 225 i.v., 1000 orally; in rats (g/kg): 1.5 i.p., 2.5 orally (Goueffon)

Pefloxacin Chemical Properties,Uses,Production

Uses

antibacterial;DNA gyrase inhibitor

Definition

ChEBI: A quinolone that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6 and 7 by ethyl, carboxy, fluorine, and 4-methylpiperazin-1-yl groups, respectively.

Pharmaceutical Applications

A 6-fluoro, 7-piperazinyl quinoline available for oral and intravenous administration. The in-vitro activity is very similar to that of norfloxacin . It is active against H. ducreyi, V. cholerae and Legionella spp., but Campylobacter and Acinetobacter spp. and pseudomonads are not susceptible. It has poor activity against pneumococci, chlamydiae, mycoplasmas and ureaplasmas. L. monocytogenes, Nocardia spp. and anaerobes are resistant.
A plasma concentration of c. 5 mg/L is achieved 1–1.5 h after a 400 mg oral dose. The plasma elimination half-life is 8.5–15 h. It is widely distributed, concentrations in bone, brain, blister fluid, CSF, saliva, sputum and prostate all approximating, and in some cases exceeding, the simultaneous plasma concentration. It is extensively metabolized to the desmethyl (= norfloxacin) and N-oxide derivatives. Some 60–70% of a dose, only about 10% of which is unchanged, appears in the urine; 25% of a dose appears in the feces, a small part contributed by elimination in the bile.
The half-life increases with hepatic impairment, but is virtually unaffected by renal failure. In patients on continuous ambulatory peritoneal dialysis (CAPD) given 800 mg followed by 400 mg every 12 h for 10–12 days, there was no significant accumulation of pefloxacin or its metabolite, norfloxacin, but concentrations of pefloxacin N-oxide rose continuously in plasma and dialysate; all concentrations fell rapidly when treatment was discontinued.
Adverse reactions are those common to the group . Most common are gastrointestinal tract disturbances, although some typical CNS reactions have been encountered. Skin eruptions (some photosensitive) occur and rashes appeared in about one-third of a group of patients who were given longterm therapy. Clinical uses are similar to those of ofloxacin.

Pefloxacin Preparation Products And Raw materials

Raw materials

Concentrated hydrochloric acid Norfloxacin Ethanol Methanesulfonic acid Pefloxacin mesylate
Triethylamine
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Preparation Products

Pefloxacin Suppliers

Global( 128)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
SUMUKHA LIFESCIENCES +919000487488 Hyderabad, India 200 58 Inquiry
Ralington Pharma +91-7948911722 +91-9687771722 Gujarat, India 1350 58 Inquiry
Nakoda Chemicals Ltd +91-9848218200 +91-9848218200 Telangana, India 15 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Central Drug House(P) Ltd. 91-11-49404040 New Delhi, India 6160 58 Inquiry
Sanket Pharmaceuticals Private Limited 08048372474Ext 910 Mumbai, India 3 58 Inquiry
Krish Pharma 09879627222 Mumbai, India 1 58 Inquiry
Smruthi Organics Limited 08069023792Ext 824 Maharashtra, India 17 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Hebei Guanlang Biotechnology Co,.LTD +86-19930503253; +8619930503252 China 5835 58 Inquiry
Supplier Advantage
SUMUKHA LIFESCIENCES 58
Ralington Pharma 58
Nakoda Chemicals Ltd 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Central Drug House(P) Ltd. 58
Sanket Pharmaceuticals Private Limited 58
Krish Pharma 58
Smruthi Organics Limited 58
CLEARSYNTH LABS LTD. 58
Hebei Guanlang Biotechnology Co,.LTD 58

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1-Ethyl-6-fluoro-1,4-dihydro-7-(4-methylpiperazino)-4-oxo-3-quinolinecarboxylic acid 1-Ethyl-6-fluoro-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid N-Methylnorfloxacin SULPHONATE DIHYDRATE RB-1589 PEFLOXACIN PEFLOXACINE MESYLATE DIHYDRATE PEFLOXACINE METHANSULFONATE DIHYDRATE PEFLOXACIN METHANE SULFONATE DIHYDRATE PERFLOXACINE 1584rb 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-methyl-1-piperazinyl)-3-quinolinecar Penaeine Penoxacine 1-Ethyl-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid 3-quinolinecarboxylicacid,1,4-dihydro-1-ethyl-6-fluoro-7-(4-methyl-1-piperazi am725 am-725 nyl)-4-oxo- EU-5306 1-ETHYL-6-FLUORO-1,4-DIHYDRO-7-(4-METHYL-1-PIPERAZINYL-4-OXO-3-QUINOLINE CARBOXYLIC ACID) METHANE SULPHONATE DIHYDRATE 1-ETHYL-6-FLUORO-7-(4-METHYLPIPERAZIN-1-YL)-4-OXO-QUINOLINE-3-CARBOXYLIC ACID PEFLOXACIN(SUBJECTTOPATENTFREE) peflacin PEFLOXACIN MESYLATE 99% 1,4-Didhydro-7(4-methylpiperazinyl)-fluoro-1-ethyl-4-oxosynolin carbonoic acid 1589mRB：Peflox 1589RB 1-Ethyl-1，4-dihydro-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid Pefloxacinium 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo- Pefloxacin USP/EP/BP 1-Ethyl-4-oxo-6-fluoro-7-(4-methyl-1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid PEFLOXACIN MESYLATE DIHYDRATE PEFLOXACIN METHANESULFONATE pefloxacine Acrylamide Impurity 31 70458-92-3 C17H20FN3O3