Tedizolid Phosphate
- CAS No.
- 856867-55-5
- Chemical Name:
- Tedizolid Phosphate
- Synonyms
- (R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyloxazolidin-2-one dihydrogenphosphate;(R)-(3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-2-oxooxazolidin-5-yl)methyl dihydrogen phosphate;133149;TR-701 FA;TEDIZOLID PHOSPHATE;Torezolid phosphate;Tedizolid Phosphate (TR-701);Tertiazole phosphate control;Tedizolid Phosphate In-House;Tedizolid Phosphate USP/EP/BP
- CBNumber:
- CB72676152
- Molecular Formula:
- C17H16FN6O6P
- Molecular Weight:
- 450.32
- MOL File:
- 856867-55-5.mol
- Modify Date:
- 2024/6/25 20:17:06
| Melting point | >235°C (dec.) |
|---|---|
| Boiling point | 725.6±70.0 °C(Predicted) |
| Density | 1.75±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO (Slightly, Sonicated) |
| form | Solid |
| pka | 1.81±0.10(Predicted) |
| color | White to Off-White |
| Stability | Hygroscopic |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H400-H410-H373-H361 | |||||||||
| Precautionary statements | P273-P391-P501-P260-P314-P501-P201-P202-P281-P308+P313-P405-P501-P273-P391-P501 | |||||||||
| NFPA 704 |
|
Tedizolid Phosphate Chemical Properties,Uses,Production
Description
Tedizolid phosphate was approved by the US FDA in June 2014 for treatment of acute bacterial skin and skin structure infections caused by susceptible gram-positive pathogens, including MRSA. Tedizolid phosphate was discovered by Dong-A Pharmaceuticals in South Korea and developed in the USA by Cubist Pharmaceuticals (acquired from Trius Therapeutics in 2013, became a wholly owned subsidiary of Merck in 2015). The worldwide commercialization rights for tedizolid phosphate are divided between Cubist in the USA, Canada, and EU, and Bayer in Asia–Pacific, Latin America, and Africa. This second-generation oxazolidinone prodrug is rapidly converted to the active form tedizolid in the presence of endogenous phosphatases. It inhibits bacterial protein synthesis by binding to the 23S ribosomal RNA of the 50S subunit of the ribosome, preventing formation of the 70S ribosomal initiation complex, and is 4-fold to 16-fold more potent against staphylococci and enterococci compared to linezolid. 251 With high oral bioavailability (approximately 90%) and long half-life (approximately 12 hours), tedizolid phosphate is the first oxazolidinone antibiotic which can be dosed once daily either orally or intravenously.
Uses
Tedizolid, known as TR-700, is an oral and i.v administered intracellular antibacterial drug.
Definition
ChEBI: A phosphate monoester resulting from the formal condensation of equimolar amounts of phosphoric acid with the hydroxy group of tedizolid . It is a prodrug of tedizolid, used for the treatment of acute bacterial skin infections caused by certain susceptibl bacteria, including Staphylococcus aureus (including methicillin-resistant strains (MRSA) and methicillin-susceptible strains), various Streptococcus species, and Enterococcus faecalis.
Tedizolid Phosphate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Viruj Pharmaceuticals Pvt Ltd | +91-9441591589 +91-9441591589 | Hyderabad, India | 33 | 58 | Inquiry |
| SEUTIC | +91-8309787199 +91-8309787199 | Hyderabad, India | 124 | 58 | Inquiry |
| Metrochem API Private Limited | +91-4069069999 +91-4069069999 | Telangana, India | 78 | 58 | Inquiry |
| METROCHEM API PRIVATE LTD | +91 - 40 -2370 0421 | Hyderabad, India | 41 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| shandong perfect biotechnology co.ltd | +86-53169958659; +8618596095638 | China | 294 | 58 | Inquiry |
| Zibo Wei Bin Import & Export Trade Co. Ltd. | +86-0533-2091136 +8613864437655 | China | 100 | 58 | Inquiry |
| BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 +86-18600796368 | China | 49 | 58 | Inquiry |
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