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Apalutamide

CAS No.: 956104-40-8

Chemical Name:: Apalutamide

Synonyms: Apalutamide;4-[7-[6-Cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl]-2-fluoro-N-methylbenzamide;4-(7-(6-cyano-5-(trifluoroMethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspirooctan-5-yl)-2-fluoro-N-MethylbenzaMide;ARN509, Apalutamide;Apalutamide (ARN-509);Copanlisib Dihydrochloride;Benzamide, 4-[7-[6-cyano-5-(trifluoromethyl)-3-pyridinyl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methyl-;4-[7-[6-Cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl]-2-fluoro-N-methylbenzamide ARN-509;ARN;AR509

CBNumber:: CB92593622

Molecular Formula:: C21H15F4N5O2S

Molecular Weight:: 477.43

MOL File:: 956104-40-8.mol

Modify Date:: 2024/7/2 8:55:41

Request For Quotation

Apalutamide Properties

Density	1.59±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	≥23.85 mg/mL in DMSO; insoluble in H2O; ≥7.33 mg/mL in EtOH
form	solid
pka	13.83±0.46(Predicted)
color	White to off-white
InChI	InChI=1S/C21H15F4N5O2S/c1-27-17(31)13-4-3-11(8-15(13)22)30-19(33)29(18(32)20(30)5-2-6-20)12-7-14(21(23,24)25)16(9-26)28-10-12/h3-4,7-8,10H,2,5-6H2,1H3,(H,27,31)
InChIKey	HJBWBFZLDZWPHF-UHFFFAOYSA-N
SMILES	C(NC)(=O)C1=CC=C(N2C(=S)N(C3=CC(C(F)(F)F)=C(C#N)N=C3)C(=O)C32CCC3)C=C1F

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P280-P305+P351+P338

NFPA 704

	0
2		0

Apalutamide Chemical Properties,Uses,Production

Apalutamide Preparation Products And Raw materials

Raw materials

5-isothiocyanato-3-(trifluoromethyl)picolinonitrile 4-(1-CYANOCYCLOBUTYLAMINO)-2-FLUORO-N-METHYLBENZAMIDE

Preparation Products

Apalutamide Suppliers

Global( 320)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Anant Pharmaceuticals Pvt Ltd	+91-8550986868 +91-9485998001	Haryana, India	461	58	Inquiry
AVD pharmaceuticals Pvt Ltd	+919860835260	Pune, India	102	58	Inquiry
Zydus Lifesciences Ltd.	+91-0265-2315243 +91-6358895661	Gujarat, India	89	58	Inquiry
Vijaya Pharma And Life Science	+91-8939866271 +91-8939866271	Tamil Nadu, India	320	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Triveni Interchem Private Limited (Group Of Triveni...	08046042087	Gujarat, India	497	58	Inquiry
Shanghai Famo Biotech Co Ltd	+8618550473860	China	513	58	Inquiry
Beijing Mesochem Technology Co.,Ltd	+8613651027935	China	191	58	Inquiry

Supplier	Advantage
Anant Pharmaceuticals Pvt Ltd	58
AVD pharmaceuticals Pvt Ltd	58
Zydus Lifesciences Ltd.	58
Vijaya Pharma And Life Science	58
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Triveni Interchem Private Limited (Group Of Triveni...	58
Shanghai Famo Biotech Co Ltd	58
Beijing Mesochem Technology Co.,Ltd	58

Apalutamide: A Promising Pharmacodynamic Drug for Prostate Cancer Treatment
Apalutamide inhibits prostate cancer growth, decreases tumor volume, and exhibits dose-proportional pharmacokinetics. Adverse ....
Feb 6，2024

What is Apalutamide
Apalutamide is a next-generation oral androgen receptor (AR) inhibitor that Janssen is developing for the treatment of prostat....
Dec 26，2023

Related Qustion

Q:Can Apalutamide Root Out Prostate Cancer?
A:No, apalutamide will not cure your prostate cancer, but it can help control it by acting to delay the need for chemotherapy.
Nov 10，2023

Apalutamide Spectrum

ARN-509(956104-40-8)¹HNMR

956104-40-8(Apalutamide)Related Search:

(2-(4-chlorophenyl)-4,4-diMethylcyclohex-1-enyl)Methanol 5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE N/A 5-isothiocyanato-3-(trifluoromethyl)picolinonitrile methyl 2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(piperazin-1-yl)benzoate

tert-butyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-bromobenzoate ABT-199 4-(1-CYANOCYCLOBUTYLAMINO)-2-FLUORO-N-METHYLBENZAMIDE 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride Methyl 4-Fluoro-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzoate

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide 4-Bromo-2-fluoro-N-methylbenzamide Y27632 (hydrochloride) Bicalutamide Enzalutamide

Galeterone Ibrutinib Olaparib

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ARN-509 AR509 AR509 100G ARV-509 ARN-509;ARN 509; ARN509 4-(7-(4-Cyano-3-(trifluoromethyl)phenyl)-8-hydroxy-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-f AR509/AR-509 ARN ARN 509; ARN-509 CS-591 4-{7-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-5-yl}-2-fluoro-N-methylbenzamide ARN-509 USP/EP/BP 4-(7-(6-cyano-5-(trifluoroMethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspirooctan-5-yl)-2-fluoro-N-MethylbenzaMide Benzamide, 4-[7-[6-cyano-5-(trifluoromethyl)-3-pyridinyl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methyl- 4-[7-[6-Cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl]-2-fluoro-N-methylbenzamide ARN-509 4-[7-[6-Cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl]-2-fluoro-N-methylbenzamide ARN509, Apalutamide Apalutamide (ARN-509) Copanlisib Dihydrochloride Apalumide Apalutamide JNJ-56021927 ARN-509 Apatamide Apalutamide JNJ 56021927 JNJ56021927 JNJ-56021927 956104-40-8 956140-40-8 C22H18F4N4O2S C21H15F4N5O2S Inhibitors LG API