AEA-P

AEA-P Structure
CAS No.
183323-26-4
Chemical Name:
AEA-P
Synonyms
AEA-P;ANANDAMIDE PHOSPHATE;PZPHIQQEQWCEGG-DOFZRALJSA-N;ARACHIDONOYL ETHANOLAMIDE PHOSPHATE;N-(2-(PHOSPHONOOXY)ETHYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE;5,8,11,14-Eicosatetraenamide, N-[2-(phosphonooxy)ethyl]-, (5Z,8Z,11Z,14Z)-
CBNumber:
CB9378032
Molecular Formula:
C22H38NO5P
Molecular Weight:
427.51
MOL File:
183323-26-4.mol
Modify Date:
2023/6/8 9:03:09

AEA-P Properties

Density 1.075±0.06 g/cm3(Predicted)
solubility DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 5 mg/ml
pka 1.86±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS02
Signal word  Danger
Hazard statements  H225
Precautionary statements  P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501
NFPA 704
3
0 0

AEA-P Chemical Properties,Uses,Production

Description

Arachidonoyl ethanolamide (AEA; ) was the first endogenous cannabinoid (CB) to be isolated and characterized as an agonist acting on the same receptors (CB1 and CB2) as Δ9-THC . Since that time, a number of related endocannabinoids have been isolated, most notably 2-arachidonoyl glycerol (2-AG; ). The phosphate ester of AEA, AEA-P, has been tested as a water soluble prodrug version of AEA in the treatment of C6 glioma cells in vivo. Here it acts with essentially the same potency as AEA. However, when tested for inhibition of AEA binding to isolated rat brain CB1 receptors, AEA-P is about 5-fold less potent as an agonist with a Ki of about 200 nM. The phosphate esters of AEA and its analogs are also structural variants of lysophosphatidic acid (LPA). However, the effects of AEA-P on the various LPA receptors have not been tested.

AEA-P Preparation Products And Raw materials

Raw materials

Preparation Products

AEA-P ANANDAMIDE PHOSPHATE ARACHIDONOYL ETHANOLAMIDE PHOSPHATE N-(2-(PHOSPHONOOXY)ETHYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE PZPHIQQEQWCEGG-DOFZRALJSA-N 5,8,11,14-Eicosatetraenamide, N-[2-(phosphonooxy)ethyl]-, (5Z,8Z,11Z,14Z)- 183323-26-4