Pyrantel pamoate
- CAS No.
- 22204-24-6
- Chemical Name:
- Pyrantel pamoate
- Synonyms
- pirantel pamoate;pyrantelembonate;helmex;NeMocid;embovin;Piranver;HelMintox;cobantril;antiminth;Early Bird
- CBNumber:
- CB9440425
- Molecular Formula:
- C34H30N2O6S
- Molecular Weight:
- 594.68
- MOL File:
- 22204-24-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/5 11:27:04
Melting point | 266-267°C |
---|---|
storage temp. | Sealed in dry,Room Temperature |
solubility | Pratically insoluble in water, soluble in dimethyl sulfoxide, pratically insoluble in methanol. |
form | powder |
color | yellow |
Water Solubility | <0.1 g/100 mL at 19 ºC |
BRN | 9034755 |
BCS Class | 4 |
InChIKey | AQXXZDYPVDOQEE-MXDQRGINSA-N |
SMILES | C(C1=C(C(C(=O)O)=CC2=CC=CC=C12)O)C1=C(C(C(=O)O)=CC2=CC=CC=C12)O.C(/C1=NCCCN1C)=C\C1SC=CC=1 |
EPA Substance Registry System | 2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy-, compd. with 1,4,5,6-tetrahydro-1-methyl-2-[(1E)-2-(2-thienyl)ethenyl]pyrimidine (1:1) (22204-24-6) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
WGK Germany | 3 |
RTECS | QL2287000 |
HS Code | 2934990002 |
Pyrantel pamoate price More Price(2)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | PHR2080 | Pyrantel Pamoate Pharmaceutical Secondary Standard; Certified Reference Material | 22204-24-6 | 1G | ₹13282.28 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 46702 | Pyrantel pamoate VETRANAL?, analytical standard | 22204-24-6 | 250MG | ₹5477.45 | 2022-06-14 | Buy |
Pyrantel pamoate Chemical Properties,Uses,Production
Chemical Properties
Pale yellow or yellow powder.
Uses
An antiparasitic agent used in the treatment of intestinal parasites such as hookworms and roundworms (Ascaris lumbricoides, aka ascarids in humans) in domesticated animals such as horses, cattle, sheep, pigs, cats, dogs, and many other species.
Indications
Pyrantel pamoate (Antiminth) is a agonist at the nicotinic acetylcholine receptor, and its actions result in depolarization and spastic paralysis of the helminth muscle. Its selective toxicity occurs primarily because the neuromuscular junction of helminth muscle is more sensitive to the drug than is mammalian muscle. This drug is administered orally, and because very little is absorbed, high levels are achieved in the intestinal tract. Less than 15% of the drug and its metabolites are excreted in urine.
General Description
Odorless light yellow to tan crystalline powder. Tasteless. Used medicinally against nematodes in animals.
Air & Water Reactions
May be sensitive to prolonged exposure to air and light . Insoluble in water.
Reactivity Profile
Pyrantel pamoate may react with acids to liberate heat. May react exothermically enough with strong oxidizing acids to ignite the reaction products. Heat is also generated with caustic solutions. Generates flammable or toxic gases with alkali metals and hydrides and other reducing agents.
Fire Hazard
Flash point data for Pyrantel pamoate are not available; however, Pyrantel pamoate is probably combustible.
Clinical Use
Trans-1,4,5,6,-Tetrahydro-1-methyl-2-[2-(2 -thienyl)ethenyl]pyrimidine pamoate (Antiminth) is a depolarizing neuromuscularblocking agent that causes spastic paralysis insusceptible helminths. It is used in the treatment of infestationscaused by pinworms and roundworms (ascariasis).Because its action opposes that of piperazine, the twoanthelmintics should not be used together. More than halfof the oral dose is excreted in the feces unchanged.Adverse effects associated with its use are primarilygastrointestinal.
Side effects
Pyrantel pamoate is active against several roundworms:
A. lumbricoides, Ancylostoma duodenale, Necator
americanus, and E. vermicularis. Pyrantel is an alternative
drug of choice in treating infections with A. lumbricoides,
E. vermicularis (pinworms), and hookworms
(N. americanus and A. duodenale). It is not recommended
for pregnant patients or for children under age
1 year.
Although most of the drug remains in the intestinal
lumen, enough can be absorbed systemically to cause
headache, dizziness, and drowsiness. No major adverse
effects have been reported on renal, hepatic, or hematological
systems.
Pyrantel pamoate Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
SNECOFRi Pvt Ltd | +91-9032850129 +91-9032850129 | Telangana, India | 404 | 58 | Inquiry |
Vedzon Healthcare Pvt Ltd | +91-9322176000 +91-9322176000 | Maharashtra, India | 51 | 58 | Inquiry |
Vivimed Labs Ltd | +914066086608 | Telangana, India | 61 | 58 | Inquiry |
Ipca Laboratories Ltd | +91-2262105000 +91-2262105000 | Maharashtra, India | 61 | 58 | Inquiry |
Chemino Pharma Ltd | +91-8689897373 +91-8689897373 | Maharashtra, India | 31 | 58 | Inquiry |
JR Corporation | +91-9099076719 +91-7096568000 | Gujarat, India | 14 | 58 | Inquiry |
Megafine Pharma | +91 9867686666, +91 9665458868 | Maharashtra, India | 29 | 58 | Inquiry |
Progress Life Sciences Pvt Ltd | +91-2265101706 +91-2249781414 | Maharashtra, India | 38 | 58 | Inquiry |
IPCA LABORATORIES LTD | +91 (22) 6210 5000 | New Delhi, India | 43 | 58 | Inquiry |
IPCA Laboratories Limited | +91 (22) 6210 5000 | New Delhi, India | 56 | 58 | Inquiry |
Supplier | Advantage |
---|---|
SNECOFRi Pvt Ltd | 58 |
Vedzon Healthcare Pvt Ltd | 58 |
Vivimed Labs Ltd | 58 |
Ipca Laboratories Ltd | 58 |
Chemino Pharma Ltd | 58 |
JR Corporation | 58 |
Megafine Pharma | 58 |
Progress Life Sciences Pvt Ltd | 58 |
IPCA LABORATORIES LTD | 58 |
IPCA Laboratories Limited | 58 |
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