ChemicalBook > Product Catalog >Chemical Reagents >Organic reagents >Sulfonates / Sulfinates salts >Phenylmethylsulfonyl fluoride
Phenylmethylsulfonyl fluoride
- CAS No.
- 329-98-6
- Chemical Name:
- Phenylmethylsulfonyl fluoride
- Synonyms
- PMSF;PHENYLMETHANESULFONYL FLUORIDE;TOSYL FLUORIDE;α-toluenesulphonyl fluoride;4-METHYLBENZENESULFONYL FLUORIDE;abs9146;PMSF PLUS;PMSF, PMs-F;BCS ASSAY KIT;PMSF solution
- CBNumber:
- CB9454820
- Molecular Formula:
- C7H7FO2S
- Molecular Weight:
- 174.19
- MOL File:
- 329-98-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/30 16:49:16
| Melting point | 92-95 °C |
|---|---|
| Boiling point | 112 °C16 mm Hg(lit.) |
| Density | 0.797 g/mL at 20 °C |
| Flash point | 222 °F |
| storage temp. | 2-8°C |
| solubility | dry solvents (ethanol, methanol, and 2-propanol): 200 mM Stock solution are stable for months at 4°C. |
| form | Needles (May Agglomerate) |
| color | White |
| Water Solubility | hydrolysis |
| Sensitive | Moisture Sensitive |
| Merck | 14,7542 |
| BRN | 2088311 |
| Stability | Moisture Sensitive |
| InChIKey | YBYRMVIVWMBXKQ-UHFFFAOYSA-N |
| CAS DataBase Reference | 329-98-6(CAS DataBase Reference) |
| EPA Substance Registry System | Benzenemethanesulfonyl fluoride (329-98-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H314 | |||||||||
| Precautionary statements | P260-P270-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | F,T,C | |||||||||
| Risk Statements | 11-34-25-23/24/25 | |||||||||
| Safety Statements | 7-16-45-36/37/39-28A-26-27 | |||||||||
| RIDADR | UN 3261 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XT8050000 | |||||||||
| F | 3-10-21 | |||||||||
| Hazard Note | Highly Toxic/Corrosive | |||||||||
| TSCA | T | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29241990 | |||||||||
| Toxicity | LD50 (24 hr) in mice (mg/kg): 215 ±55 i.p. (Pinsky) | |||||||||
| NFPA 704 |
|
Phenylmethylsulfonyl fluoride price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | P7626 | Phenylmethanesulfonyl fluoride ≥98.5% (GC) | 329-98-6 | 250MG | ₹2321 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P7626 | Phenylmethanesulfonyl fluoride ≥98.5% (GC) | 329-98-6 | 1G | ₹2479.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P7626 | Phenylmethanesulfonyl fluoride ≥98.5% (GC) | 329-98-6 | 5G | ₹6572.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P7626 | Phenylmethanesulfonyl fluoride ≥98.5% (GC) | 329-98-6 | 25G | ₹26216.75 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P7626 | Phenylmethanesulfonyl fluoride ≥98.5% (GC) | 329-98-6 | 100G | ₹87818.2 | 2022-06-14 | Buy |
Phenylmethylsulfonyl fluoride Chemical Properties,Uses,Production
Chemical Properties
White to cream solid
Uses
Phenylmethylsulfonyl fluoride is used as a Protease inhibitor such as Chymotrypsin, Trypsin and Thrombin as well as Acetylcholineesterase.
Definition
ChEBI: Phenylmethanesulfonyl fluoride is an acyl fluoride with phenylmethanesulfonyl as the acyl group. It has a role as a serine proteinase inhibitor. It derives from a phenylmethanesulfonic acid.
General Description
In biochemistry, Phenylmethylsulfonyl fluoride (PMSF) is a serine protease inhibitor commonly used in preparation of cell lysates. It is rapidly degraded in water and stock solutions are usually made up in anhydrous ethanol, isopropanol, corn oil, or DMSO (Dimethyl sulfoxide).
Hazard
Extremely corrosive and destructive to tissues. May cause irreversible eye damage. PMSF hydrolyzes upon exposure to water/moisture, liberating a toxic and corrosive gas (hydrogen flouride) that in contact with metal surfaces can generate flammable and/or explosive hydrogen gas.
storage
Phenylmethylsulfonyl fluoride (PMSF) is incompatible with water, acids, bases, and strong oxidizing agents. Do not store PMSF in glass or mild steel/galvanized containers. Store in a cool, dry, and well-ventilated area away from incompatible chemicals.
Purification Methods
Purify PMSF by recrystallisation from *C6H6, pet ether or CHCl3/pet ether. [Davies & Dick J Chem Soc 483 1932, cf Tullock & Coffman J Org Chem 23 2016 1960.] It is a general protease inhibitor (specific for trypsin and chymotrypsin) and is a good substitute for diisopropylphosphoro floridate [Fahrney & Gould J Am Chem Soc 85 997 1963]. [Beilstein 11 III 331.]
Phenylmethylsulfonyl fluoride Preparation Products And Raw materials
Raw materials
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Global( 396)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Reax Chemicals | 08048372701Ext 416 | Hyderabad, India | 4223 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| ORGANO FINE CHEMICALS | +91-22-42128300 | Mumbai, India | 202 | 58 | Inquiry |
| Vyas Bio Life Sciences Pvt. Ltd | -65546373 | Hyderabad, India | 1213 | 58 | Inquiry |
| Spectrochem Private Limited | 08048372608Ext 246 | Maharashtra, India | 1056 | 58 | Inquiry |
| Maas Pharma Chemicals | +91-9958666224 | Delhi, India | 1607 | 58 | Inquiry |
| HiMedia Laboratories | 91-22-61471919 | Maharashtra, India | 1843 | 58 | Inquiry |
| Anand Agencies | 91-20-24454597 | Maharashtra, India | 2337 | 58 | Inquiry |
| Oceanic Pharmachem Pvt. Ltd. | 91-22-42128600 | Maharashtra, India | 2006 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| JSK Chemicals | 58 |
| Reax Chemicals | 58 |
| Sisco Research Laboratories Pvt. Ltd. | 58 |
| ORGANO FINE CHEMICALS | 58 |
| Vyas Bio Life Sciences Pvt. Ltd | 58 |
| Spectrochem Private Limited | 58 |
| Maas Pharma Chemicals | 58 |
| HiMedia Laboratories | 58 |
| Anand Agencies | 58 |
| Oceanic Pharmachem Pvt. Ltd. | 58 |
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