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NOVOBIOCIN SODIUM SALT

CAS No.: 1476-53-5

Chemical Name:: NOVOBIOCIN SODIUM SALT

Synonyms: NOVOBIOCIN SODIUM;ALBAMYCIN;U-6591;Albadry;NSC 2382;Robicina;Vulcamycin;Albycin sodium;STREPTONIVICIN;MSRV Selective

CBNumber:: CB9493214

Molecular Formula:: C31H37N2NaO11

Molecular Weight:: 636.63

MOL File:: 1476-53-5.mol

Modify Date:: 2023/9/4 15:50:00

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NOVOBIOCIN SODIUM SALT Properties

Melting point	215-220 C
alpha	D24 -38° (c = 2.5 in 95% ethanol); D24 -33° (c = 2.5 in water)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	H2O: soluble50mg/mL
form	White to yellow solid
color	white to faintly beige
PH	7.5 (100g/l, H2O, 25℃)
optical activity	[α]20/D 48±3°, c = 1% in ethanol
Water Solubility	Soluble in water at 100mg/ml. Also soluble in ethanol or DMSOSoluble in water, ethanol, dimethyldulfoxide and methanol.
Merck	13,6755
BRN	3892910
Stability	Hygroscopic

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H317-H319

Precautionary statements

P261-P264-P280-P301+P312-P302+P352-P305+P351+P338

Hazard Codes

Xi,Xn

Risk Statements

43-36-36/37/38-20/21/22

Safety Statements

36-36/37-26-37/39

WGK Germany

RTECS

RD5425000

8-10

HS Code

2941 90 00

Toxicity

LD50 orally in Rabbit: 3500 mg/kg

NFPA 704

	0
2		0

NOVOBIOCIN SODIUM SALT price More Price(13)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	N6160	Novobiocin sodium meets USP testing specifications	1476-53-5	1G	₹4589.8	2022-06-14	Buy
Sigma-Aldrich(India)	N6160	Novobiocin sodium meets USP testing specifications	1476-53-5	5G	₹15836.98	2022-06-14	Buy
Sigma-Aldrich(India)	N1628	Novobiocin sodium salt ≥90% (HPLC)	1476-53-5	1G	₹5293.43	2022-06-14	Buy
Sigma-Aldrich(India)	N6160	Novobiocin sodium meets USP testing specifications	1476-53-5	25G	₹62460.25	2022-06-14	Buy
Sigma-Aldrich(India)	N1628	Novobiocin sodium salt ≥90% (HPLC)	1476-53-5	5G	₹10489.43	2022-06-14	Buy

Product number	Packaging	Price	Buy
N6160	1G	₹4589.8	Buy
N6160	5G	₹15836.98	Buy
N1628	1G	₹5293.43	Buy
N6160	25G	₹62460.25	Buy
N1628	5G	₹10489.43	Buy

NOVOBIOCIN SODIUM SALT Chemical Properties,Uses,Production

Chemical Properties

crystalline

Uses

Novobiocin is an antibiotic that acts as an inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Studies show that Novobiocin is also an inhibitor of retrovirus RNA-dependent DNA-polymerase. Novobiocin is used in the production of positively supercoiled plasmid DNA.
Novobiocin sodium salt is twice as bioavailable as the calcium salt and 50 times more available than the parent acid.

Clinical Use

The action of novobiocin is largely bacteriostatic. Itsmode of action is not known with certainty, though it doesinhibit bacterial protein and nucleic acid synthesis. Studiesindicate that novobiocin and related coumarin-containingantibiotics bind to the subunit of DNA gyrase and possiblyinterfere with DNA supercoiling and energy transductionin bacteria. The effectiveness of novobiocin is confinedlargely to Gram-positive bacteria and a few strains of P. vulgaris.Its low activity against Gram-negative bacteria is apparentlybecause of poor cellular penetration.
Although cross-resistance to other antibiotics is reportednot to develop with novobiocin, resistant S. aureus strainsare known. Consequently, the medical use of novobiocin isreserved for the treatment of staphylococcal infections resistantto other antibiotics and sulfas and for patients allergicto these drugs. Another shortcoming that limits the usefulnessof novobiocin is the relatively high frequency ofadverse reactions, such as urticaria, allergic rashes, hepatotoxicity,and blood dyscrasias.

Safety Profile

Poison by intraperitoneal and subcutaneous routes. Moderately toxic by ingestion. Mutation data reported. An antibiotic with serious side effects which include liver and blood disease. It may also promote the development of resistant strains of staphylococcus. When heated to decomposition it emits toxic fumes of NOx and Na2O.

Purification Methods

The sodium salt has been recrystallised from MeOH, then dried at 60o/0.5mm. [Sensi et al, Anal Chem 29 1611 1957, Kaczka et al. J Am Chem Soc 78 4126 1956, Beilstein 18/8 IV 8125.]

NOVOBIOCIN SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

NOVOBIOCIN SODIUM SALT Suppliers

Global( 197)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Sisco Research Laboratories Pvt. Ltd.	+91-22-4268 5800	Mumbai, India	4317	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Triveni chemicals	08048762458	New Delhi, India	6093	58	Inquiry
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	China	21677	55	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29901	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Sisco Research Laboratories Pvt. Ltd.	58
SynZeal Research Pvt Ltd	58
Triveni chemicals	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
TargetMol Chemicals Inc.	58

NOVOBIOCIN SODIUM SALT Spectrum

NOVOBIOCIN SODIUM SALT(1476-53-5)¹HNMR

1476-53-5(NOVOBIOCIN SODIUM SALT)Related Search:

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NOVOBIOCIN SODIUM SALT MEPHENESIN 3-METHYLHIPPURIC ACID 6-Deoxy-L-glucose 4-METHOXY-4-METHYL-2-PENTANOL

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albamycin(capsule) Albamycinsodium Cathomycinsodium Cathomycinsodiumlyovac Monosodiumnovobiocin Novobiocin,sodiumderiv. Novobiocinmonosodium N-[7-[(3-O-Carbamoyl-4-O,5-C-dimethyl-6-deoxy-β-L-lyxo-hexopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-sodiooxy-3-(3-methyl-2-butenyl)benzamide Benzamide, N-7-3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-.alpha.-L-lyxo-hexopyranosyloxy-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl-4-hydroxy-3-(3-methyl-2-butenyl)-, monosodium salt 7-[4-(Carbamoyloxy)-tetrahydro-3-hydroxy-5-methoxy-6,6-dimethylpyran-2-yl]-4-hydroxy-3-[4-hydroxy-3-(3-methyl-2-butenyl)benzamido]-8-methyl-, sodium salt Albadry Albycin sodium Antibiotic from streptomyces spheroides Benzamide, N-[7-[[3-o-(aminocarbonyl)-6-deoxy-5-C-methyl-4-o-methyl-.beta.-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-butenyl)-, monosodium salt Novobiocin sodiuM(AlbaMycin) N-[7-[[3-O-(AMinocarbonyl)-6-deoxy-5-C-Methyl-4-O-Methyl-α-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-Methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-Methyl-2-butenyl)benzaMide MonosodiuM salt NSC 2382 Crystallinic acid MonosodiuM salt Robicina Novobiocin-Na-salt research grade N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-α-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-buten-1-yl)-benzamide, sodium salt (1:1) Novobiocin Sodium (U-6591) Sodiumalbamycin Sodiumnovobiocin Vulcamycin MSRV SELECTIVE SUPPLEMENT NOVOBIOCIN MONOSODIUM SALT NOVOBIOCIN NA-SALT NOVOBIOCIN SODIUM SALT STREPTONIVICIN U-6591 Novobiocin sodium salt, Antibiotic for Culture Media Use Only novobiocin sodium crystalline novobiocin sodium usp NOVOBIOCIN SODIUM SALT VETRANAL, 250 NOVOBIOCINE MONOSODIUM FPC(CRM STANDARD) NOVOBIOCIN SODIUM SALT APPOX. 90% Novobiocin Sodium, >98% MSRV Selective Novobiocin, Sodium Salt - CAS 1476-53-5 - Calbiochem Benzamide,N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-a-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-buten-1-yl)-,sodium salt (1:1) 4-Hydroxy-3-[4-hydroxy-3-(3-methylbut-2-enyl) benzamido]-8-methylcoumarin-7-yl 3-O-carbamoyl-5,5-di-C-methyl-α-L-lyxofuranoside sodium salt Novobiocin Sodium Salt Standard Novobiocin sodium saL Sodium 4-((7-(((2R,3R,4S,5R)-4-(carbamoyloxy)-3-hydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-8-methyl-2-oxo-2H-chromen-3-yl)carbamoyl)-2-(3-methylbut-2-en-1-yl)phenolate NOVOBIOCIN SODIUM SALT USP/EP/BP Novobiocin Sodium Salt (NVB), 95% NOVOBIOCIN SODIUM ALBAMYCIN Neomycin sodium salt 1476-53-5 C31H35N2NaO11 C31H35N2O11Na BioChemical Antibiotics A to Z Antibiotics Antibiotics N-S Aromatcis