Omethoate
![Omethoate Structure](CAS/GIF/1113-02-6.gif)
- CAS No.
- 1113-02-6
- Chemical Name:
- Omethoate
- Synonyms
- S6876;s-6876;MODERN;B-45432;FOLIMAT;OMETHOAT;ent25,776;P=O-Rogor;bay 45432;OMETHOATE
- CBNumber:
- CB6109938
- Molecular Formula:
- C5H12NO4PS
- Molecular Weight:
- 213.19
- MOL File:
- 1113-02-6.mol
- Modify Date:
- 2023/5/15 10:43:33
Melting point | -27.9°C |
---|---|
Boiling point | 135°C |
Density | 1.3200 |
vapor pressure | 3.3×10-3Pa (20 °C) |
Flash point | 100 °C |
storage temp. | 0-6°C |
solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
Water Solubility | Miscible |
pka | 14.40±0.46(Predicted) |
form | liquid |
BRN | 1785256 |
Stability | Hygroscopic |
CAS DataBase Reference | 1113-02-6(CAS DataBase Reference) |
NIST Chemistry Reference | Omethoate(1113-02-6) |
EPA Substance Registry System | Omethoate (1113-02-6) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() GHS06,GHS09 |
---|---|
Signal word | Danger |
Hazard statements | H300-H311-H400 |
Precautionary statements | P264-P270-P273-P280-P301+P310-P302+P352+P312 |
Hazard Codes | T+;N,N,T+,T |
Risk Statements | 21-25-50 |
Safety Statements | 1/2-23-36/37-45-61 |
RIDADR | 3018 |
WGK Germany | 3 |
RTECS | TF8050000 |
HazardClass | 6.1(a) |
PackingGroup | II |
HS Code | 29309090 |
Toxicity | LD50 oral in rabbit: 50mg/kg |
Omethoate Chemical Properties,Uses,Production
Uses
Omethoate is a systemic insecticide used for the control of (mostly) sucking insects and mites in a wide variety of crops.
Contact allergens
Contact dermatitis from omethoate-dimethoxon is rare.
Metabolic pathway
Omethoate is the P=O analogue (oxon) of dimethoate. Dimethoate is metabolised via oxidative desulfuration to omethoate which is the active anti-acetylcholinesterase metabolite. This biotransformation occurs in all media: hence the metabolic pathways of both compounds have much in common. However, degradative pathways acting directly on dimethoate such as O-demethylation, N-demethylation and hydrolysis of the amide function mean that the balance between activation and degradative metabolism will influence their respective selective toxicities. In mammals there are two main routes of degradation: (i) glutathione transferase mediated O-demethylation (ii) hydrolysis to N-methylthioglycolamide which is S-methylated by S-adenosylmethionine and subsequently thiooxidised. In soil and plants the N-methylthioglycolamide moiety formed from the hydrolysis of omethoate undergoes a complex series of C1, C2 and C3 biotransformations ultimately leading to oxalate and citrate respectively and total degradation to C02. The information reported below is derived largely from an evaluation prepared by the UK MAFF Pesticide Safety Directorate (PSD, 1993).
Metabolism
Orally administered omethoate to rats is rapidly metabolized and excreted in the urine; the main metabolites are O-demethylomethoate and N-methyl-2- methylsulfinylacetamide. O-Demethylation and hydrolysis of the P?S bond are main degradation routes both in mammals and plants. Omethoate is rapidly degraded in soils with DT50 of a few days.
Omethoate Preparation Products And Raw materials
Raw materials
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