Cefpodoxime
- CAS No.
- 80210-62-4
- Chemical Name:
- Cefpodoxime
- Synonyms
- CPDX;Cefpodoxima;Cefpodoxime;Cefpodoximum;Unii-7R4F94tvgy;Cefpodoxime sulfate;Cefpodoximum [latin];Cefpodoxima [spanish];Cefpodoxime USP/EP/BP;Cefpodoxime tablet 200mg
- CBNumber:
- CB9511604
- Molecular Formula:
- C15H17N5O6S2
- Molecular Weight:
- 427.46
- MOL File:
- 80210-62-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:42
| Melting point | 200-202°C |
|---|---|
| Density | 1.78±0.1 g/cm3(Predicted) |
| RTECS | XI0367365 |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Soluble in DMSO |
| pka | 2.77±0.50(Predicted) |
| form | Solid |
| color | White to off-white |
| Sensitive | Light Sensitive |
| BRN | 6021381 |
| Stability | Hygroscopic |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H317-H334 |
| Precautionary statements | P261-P280-P342+P311 |
| Hazard Codes | Xn |
| Risk Statements | 42/43 |
| Safety Statements | 22-36/37-45 |
| WGK Germany | 3 |
Cefpodoxime Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
A metabolite of Cefpodoxime Proxetil. An antibacterial.
Definition
ChEBI: A third-generation cephalosporin antibiotic with methoxymethyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamino substituents at positions 3 and 7, respectively, of the cephem skeleton. Given by mouth as its proxetil ester prodrug, it is used to treat acute otitis media, pharyngitis, and sinusitis.
Antimicrobial activity
It is stable to a wide range of plasmid-mediated β-lactamases. It induces the chromosomal β-lactamases of Ps. aeruginosa, Enterobacter spp., S. marcescens and Citrobacter spp., but is a less potent inducer than cefoxitin.
Pharmacokinetics
Oral absorption: c. 50%
Cmax 200 mg oral: 2.1 mg/L after 3 h
Plasma half-life: c. 2.2 h
Volume of distribution: c. 35 L
Plasma protein binding: 20–30%
Absorption and distribution
The ester is rapidly hydrolyzed to the parent compound in the small intestine. Bioavailability increases to 65% if taken with food, but antacids and H2-receptor antagonists reduce absorption. Unabsorbed drug is hydrolyzed and excreted in the feces.
It is well distributed and penetrates well into tissues (including lung tissue) and inflammatory exudate to achieve concentrations inhibitory to common pathogens.
Metabolism and excretion
The hydrolyzed prodrug is not subject to further metabolism. About 80% of the absorbed compound (30–40% of the original dose) appears in the urine over 24 h. Excretion is by glomerular filtration and tubular secretion; probenecid delays secretion and increases the peak plasma concentration.
Metabolism and excretion
The hydrolyzed prodrug is not subject to further metabolism. About 80% of the absorbed compound (30–40% of the original dose) appears in the urine over 24 h. Excretion is by glomerular filtration and tubular secretion; probenecid delays secretion and increases the peak plasma concentration.
Clinical Use
Cefpodoxime has been used principally for the treatment of upper and lower respiratory tract infections in children and adults.
Side effects
The drug is well tolerated, but gastrointestinal disturbance with diarrhea is common. Pseudomembranous colitis has been reported occasionally. Other side effects are those common to cephalosporins.
Cefpodoxime Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMXTREE STANDARDS | +919872732255 | Punjab, India | 96 | 58 | Inquiry |
| J S LABS | +91-7330612784 +91-7330612784 | Tamil Nadu, India | 160 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Del Trade International | 91-11-29967331 | Delhi, India | 35 | 58 | Inquiry |
| CLEANCHEM LABORATORIES LLP | +91 98921 69560 | New Delhi, India | 326 | 58 | Inquiry |
| Anant Pharmaceuticals Pvt. ltd | +91 8550986868 | Maharashtra, India | 736 | 58 | Inquiry |
| G.C Chemie Pharmie Ltd. | 91-22-26332365 | Maharashtra, India | 42 | 58 | Inquiry |
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