CONCANAMYCIN A
- CAS No.
- 80890-47-7
- Chemical Name:
- CONCANAMYCIN A
- Synonyms
- FOLIMYCIN;S-45A;A661-I;x4357b;NSC 674620;Canavalin A;Concanamycin;CONCANAMYCIN A;A,ConcanaMycin;Antibiotic S-45A
- CBNumber:
- CB9696475
- Molecular Formula:
- C46H75NO14
- Molecular Weight:
- 866.09
- MOL File:
- 80890-47-7.mol
- Modify Date:
- 2025/1/27 9:38:02
| Melting point | 179-180℃ (dichloromethane ethanol ) |
|---|---|
| Boiling point | 966.4±65.0 °C(Predicted) |
| Density | 1.20±0.1 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | Soluble in DMSO |
| form | Lyophilized solid |
| pka | 12.46±0.70(Predicted) |
| color | White |
| BRN | 3560277 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H310+H330-H319 | |||||||||
| Precautionary statements | P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 26/27/28-36 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 3462 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | CB9732000 | |||||||||
| F | 10-21 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2941900000 | |||||||||
| NFPA 704 |
|
CONCANAMYCIN A price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C9705 | Concanamycin A ≥70% (HPLC) | 80890-47-7 | 25μG | ₹20978.85 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C9705 | Concanamycin A ≥70% (HPLC) | 80890-47-7 | 0.1MG | ₹58671.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 27689 | Concanamycin A from Streptomyces sp., ≥80% (HPLC) | 80890-47-7 | 50μG | ₹28794.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 27689 | Concanamycin A from Streptomyces sp., ≥80% (HPLC) | 80890-47-7 | 250μG | ₹63163.88 | 2022-06-14 | Buy |
CONCANAMYCIN A Chemical Properties,Uses,Production
Uses
Concanamycin A is the major analogue of the concanamycin complex produced by Streptomyces sp.. It has been shown to act as a potent and specific vacuolar-ATPase inhibitor. Concanamycin A inhibits the acidification of organelles and blocks cell surface expression of viral envelope glycoproteins without affecting their synthesis. It also interferes with intracellular protein trafficking and inhibits perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. Concanamycins are structurally related to the bafilomycins.
Definition
ChEBI: A concanamycin in which the lactone ring contains 4 double bonds and is substituted by 4 methyl groups, 2 hydroxy groups, 2 methoxy groups and an ethyl group.
General Description
Chemical structure: macrolide
Biological Activity
Specific inhibitor of V-type (vacuolar) H + -ATPase that displays > 2000-fold selectivity over other H + -ATPases (IC 50 values are 9.2, > 20000, > 20000 and > 20000 nM for yeast V-type, F-type, P-type H + -ATPases and porcine P-type Na + ,K + -ATPase respectively). Blocks cell surface expression of virus envelope glycoproteins without affecting synthesis and exhibits cytotoxicity in several cell lines.
CONCANAMYCIN A Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19552 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 32159 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | China | 7859 | 58 | Inquiry |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +8618791163155 | China | 3558 | 58 | Inquiry |
| Aladdin Scientific | United States | 52924 | 58 | Inquiry | |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 1316706386 | China | 25003 | 65 | Inquiry |
| Olix (Shanghai) Pharmaceutical Technology Co., Ltd | 17316404525 | China | 9976 | 58 | Inquiry |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | China | 4729 | 58 | Inquiry |
| Shanghai klamar Reagent Co., LTD | 4001650900 13817534909 | China | 10717 | 58 | Inquiry |
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