amisometradine
- CAS No.
- 550-28-7
- Chemical Name:
- amisometradine
- Synonyms
- Rolicton;amisometradine;Aminoisometradin;Aminoisometradine;6-Amino-3-methyl-1-(2-methylallyl)uracil;6-amino-3-methyl-1-(2-methylallyl)pyrimidine-2,4-quinone;6-amino-3-methyl-1-(2-methylprop-2-enyl)pyrimidine-2,4-dione;6-azanyl-3-methyl-1-(2-methylprop-2-enyl)pyrimidine-2,4-dione;6-Amino-3-methyl-1-(2-methyl-2-propenyl)pyrimidine-2,4(1H,3H)-dione;2,4(1H,3H)-Pyrimidinedione, 6-amino-3-methyl-1-(2-methyl-2-propen-1-yl)-
- CBNumber:
- CB9920813
- Molecular Formula:
- C9H13N3O2
- Molecular Weight:
- 195.22
- MOL File:
- 550-28-7.mol
- Modify Date:
- 2023/5/4 17:34:39
| Melting point | 175° |
|---|---|
| Boiling point | 331.89°C (rough estimate) |
| Density | 1.1985 (rough estimate) |
| refractive index | 1.5100 (estimate) |
| storage temp. | Amber Vial, -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 4.97±0.70(Predicted) |
| color | White to Pale Beige |
| Stability | Light Sensitive |
amisometradine Chemical Properties,Uses,Production
Originator
Rolicton,Searle,US,1956
Manufacturing Process
Preparation of the ethyl analog is as follows (methyl isocyanate is used in
amisometradine manufacture).
To a cooled and stirred solution of 142 parts of methallylamine in 900 parts of
benzene, 156 parts of ethyl isocyanate are added dropwise. Upon
concentration in vacuum N-ethyl-N'-methallylurea is obtained.
260 parts of this urea derivative are dissolved in 500 parts of acetic anhydride
and treated with 157 parts of cyanoacetic acid at 60°C and heated at that
temperature for 2 hours. The solution is then concentrated in vacuum to a
syrup. 100 parts of water are added and the vacuum distillation is repeated.
The remaining syrup contains a mixture of N-cyanoacetyl-N-ethyl-N'-
methallylurea and a small quantity of N-cyanoacetyl-N-methallyl-N'-ethylurea.
This syrup is treated with sufficient 20% sodium hydroxide solution to raise
the pH to 10. A violent reaction occurs. The reaction mixture is diluted with 50
parts of water, stirred, cooled and filtered. The material collected on the filter
is recrystallized from 10% ethanol to yield a mixture of 1-methallyl-3-ethyl-6-
amino-1,2,3,4-tetrahydro-2,4-pyrimidinedione and 1-ethyl-3-methallyl-6-
amino-1,2,3,4-tetrahydro-2,4-pyrimidinedione melting at about 157-159°C.
Therapeutic Function
Diuretic
amisometradine Preparation Products And Raw materials
Raw materials
Preparation Products
amisometradine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | China | 9003 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| Shanghai Haohong Scientific Co., Ltd. | 400-400-8210725 | China | 40041 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 4008200310 | China | 24017 | 58 | Inquiry |
| Lanospharma Laboratories Co.,Ltd | 13440048448 | China | 6343 | 56 | Inquiry |
| Shanghai Hao Zhun Biological Technology Co., Ltd. | 15800340161 | CHINA | 6846 | 58 | Inquiry |
| United States Biological | 800.520.3011 or 781.639.5092 | United States | 6256 | 80 | Inquiry |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 15229059051 | China | 9971 | 58 | Inquiry |
| LGC Science (Shanghai) Ltd. | 17717235263 | China | 11572 | 58 | Inquiry |