dehydroemetine
- CAS No.
- 4914-30-1
- Chemical Name:
- dehydroemetine
- Synonyms
- BT 436;Mebadin;Dametin;Ro 1-9334/19;dehydroemetine;2,3-DEHYDROEMETINE;dehydroemetine USP/EP/BP;Dehydroemetine hydrochloride;4H-Benzo[a]quinolizine, 3-ethyl-1,6,7,11b-tetrahydro-9,10-dimethoxy-2-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolinyl]methyl]-, (11bS)-;(11bS)-2-[[(1R)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl]-3-ethyl-9,10-dimethoxy-4,6,7,11b-tetrahydro-1H-pyrido[2,1-a]isoquinoline
- CBNumber:
- CB9942510
- Molecular Formula:
- C29H38N2O4
- Molecular Weight:
- 478.62
- MOL File:
- 4914-30-1.mol
- Modify Date:
- 2024/7/2 8:55:42
dehydroemetine Chemical Properties,Uses,Production
Pharmaceutical Applications
The synthetic racemic derivative of the plant alkaloid
emetine. Formulated as the hydrochloride for intramuscular
administration.
Like the parent compound, emetine, it
inhibits
E. histolytica at concentrations of 1–10 mg/L in vitro,
but it is more active than the parent in animal models. Drugresistance
in E. histolytica is rare.
No human pharmacokinetic data are available. A halflife
of 2 days, compared with 5 days for emetine, has been
reported. There is selective tissue binding and accumulation
in the liver, lung, spleen and kidney.
It is considerably less toxic than emetine, possibly because
it is more rapidly eliminated. Nevertheless, nausea, vomiting,
diarrhea and abdominal cramps frequently occur.
Neuromuscular effects have also been reported. More serious
cardiotoxic effects can lead to electrocardiogram (EGG)
changes, tachycardia and a drop in blood pressure.
It was formerly used as a second-line treatment in severe
intestinal or hepatic amebiasis, but is no longer recommended
for use.
dehydroemetine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21676 | 55 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 26216 | 58 | Inquiry |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | China | 33350 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 17691182729 18161915376 | China | 10011 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 4008200310 | China | 24017 | 58 | Inquiry |
| Lanospharma Laboratories Co.,Ltd | 13440048448 | China | 6343 | 56 | Inquiry |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | China | 12308 | 58 | Inquiry |
| MedChemExpress | 021-58955995 | United States | 6398 | 58 | Inquiry |