インカドロン酸二ナトリウム 化学特性,用途語,生産方法
効能
骨吸収抑制薬, ファルネシルピロリン酸合成酵素阻害薬
説明
Bisphonal, a new third generation drug, was launched in Japan for the
treatment of osteoporosis. It can be prepared in two steps by heating
cycloheptylamine, triethylorthoformate and diethyl phosphite followed by ester
hydrolysis. The mechanism of action is not well understood. Bisphonal has no effect
on bone mineralization but tightly binds to calcified bone matrix and inhibits bone
resorption. It causes a decrease in the number and activity of osteoclasts
(morphology and decrease in H
+ secretion). They seem to undergo cell death with an
impairment in the process of osteoclast formation. Bisphonal does not induce
osteomalacia and its activity is partly mediated through osteoblasts (releases an
inhibitor of osteoclast recruitment). It is a potent inhibitor of squalene synthase (50-fold) maybe by Mg
2+ chelation or as a pyrophosphate mimic, undergoes practically no
metabolism, and stimulates renal production of 1,25-dihydroxyvitamin D.
使用
Incandronate is a bisphosphonate derivative. Bisphosphonates are most widely used as agents for treating osteoporosis and have also been used for other purposes such as herbicides, anticancer agents, and antiparasitics.
インカドロン酸二ナトリウム 上流と下流の製品情報
原材料
準備製品