デスベンラファキシンコハク酸塩水和物
デスベンラファキシンコハク酸塩水和物 物理性質
- 貯蔵温度 :
- Store at +4°C
- 溶解性:
- DMSO:3.0(Max Conc. mg/mL);7.51(Max Conc. mM)
- 外見 :
- Powder
- 色:
- White to off-white
- 安定性：:
- Hygroscopic
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 絵表示（GHS） |
|
| 注意喚起語 |
警告 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
|
P264, P270, P301+P312, P330, P501 |
| H315 |
皮膚刺激 |
皮膚腐食性/刺激性 |
2 |
警告 |
|
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
強い眼刺激 |
眼に対する重篤な損傷性/眼刺激 性 |
2A |
警告 |
|
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
呼吸器への刺激のおそれ |
特定標的臓器毒性、単回暴露； 気道刺激性 |
3 |
警告 |
|
|
|
| 注意書き |
| P261 |
粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。 |
| P305+P351+P338 |
眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。 |
|
デスベンラファキシンコハク酸塩水和物 価格
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
デスベンラファキシンコハク酸塩水和物 化学特性,用途語,生産方法
用途
セロトニン / ノルアドレナリンの再取り込み阻害剤です（SNRI）。
SERT 及び NET に選択的です（Ki 値＝ 40.2 nM（SERT）、558.4 nM（NET））。
［3H］5-HT 及び［3H］NE の取り込みを阻害します。Venlafaxine の主要な活性代謝物のコハク酸塩体です。
効能
抗うつ薬, セロトニン・ノルアドレナリン再取り込み阻害薬
説明
Desvenlafaxine Succinate is a dual serotonin and norepinephrine
reuptake inhibitor (SNRI) that was approved for the
treatment of major depressive disorder (MDD) in the United
States in 2008. In order to improve the efficacy and
safety profile of venlafaxine, Wyeth discovered and developed
one of the major metabolites of venlafaxine, namely the
O-desmethyl metabolite (desvenlafaxine). Desvenlafaxine is
also being developed for the treatment of moderate to severe
vasomotor symptoms associated with menopause (i.e., hot
flashes and night sweats) and is also in phase III clinical trials
to study it’s effectiveness in treating fibromyalgia and
neuropathic pain.
使用
Antianxiety therapeutic
合成
Desvenlafaxine has been prepared via
two different routes, and both are described in the scheme.
The first route involved simple demethylation of venlafaxine
(67) using L-selectride in dimethoxyethane giving desvenlafaxine
68 as its free base in 91% yield. Compound
68 was then recrystallized with succinic acid in acetone/
water to give desvenlafaxine succinate (VIII) in 86%
yield. An alternative method to prepare desvenlafaxine is
described in the bottom portion of the scheme. 4-Benzyloxyphenylacetic
acid 69 was converted to its corresponding
acid chloride upon treatment with thionyl chloride and catalytic
DMF in refluxing methylene chloride. The crude
reaction mixture was added to a solution of dimethylamine
hydrochloride and triethyl amine in methylene chloride at 5
??C to give dimethylacetamide 70 in 90% yield. Deprotonation
of 70 with LHMDS in THF at -70 ??C followed by addition
of cyclohexanone gave alcohol 71 in 82% yield. Reduction
of the acetamide with borane THF complex in refluxing THF produced dimethyl amine 72 in 66% yield. Catalytic
hydrogenation in the presence of 20% Pd/C effected debenzylation
of 72 to give desvenlafaxine free base 68 in 87%
yield.
デスベンラファキシンコハク酸塩水和物 上流と下流の製品情報
原材料
準備製品
デスベンラファキシンコハク酸塩水和物 生産企業
Global( 196)Suppliers
デスベンラファキシンコハク酸塩水和物 スペクトルデータ(1HNMR)
386750-22-7(デスベンラファキシンコハク酸塩水和物)キーワード:
- 386750-22-7
- Desvenlafaxine succinate
- 4-(2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol succinate hydrate
- Desvenlafaxine succinate monohydrate
- Pristiq
- Unii-zb22enf0xr
- Desvenlafaxine (succinate hydrate)
- C16H25NO2.HOOCCH2CH2COOH.H2O
- 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenolsuccinate
- WY 45233 succinate
- (1R)-2-(2-(diMethylaMino)-1-phenylethyl)cyclohexanol
- Desvenlafaxine (O-DesMethyl Venlafaxine) Succinate Monohydrate
- Butanedioic acid, compd. with 4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol, hydrate (1:1:1)
- 4-(2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol succinate monohydrate
- 2-(1-Hydroxycyclohexyl)-2-(4-hydroxyphenyl)ethyl]dimethylammonium3-carboxypropanoatemonohydrate
- Desvenla succinate
- O-Desmethylvenlafaxine succinate hydrate
- Pristiq succinate hydrate
- PRISTIQ SUCCINATE HYDRATE;O-DESMETHYLVENLAFAXINE SUCCINATE HYDRATE
- Desvenlafaxine succinic acid monohydrate
- [2H6]-rac-O-Desmethyl Venlafaxine Succinate Hydrate
- Desvenlafaxine succinate USP/EP/BP
- RAC-O-DESMETHYL VENLAFAXINE-D6 SUCCINATE HYDRATE
- Desvenlafaxine succinateQ: What is
Desvenlafaxine succinate Q: What is the CAS Number of
Desvenlafaxine succinate Q: What is the storage condition of
Desvenlafaxine succinate Q: What are the applications of
Desvenlafaxine succinate
- TIANFUCHEM-- Desvenlafaxine succinate
- Desvenlafaxine Succinate (1-[2-(Dimethylamino)-1-(4-hydroxyphenyl)ethyl]cyclohexanol hydrogen butanedioate monohydrate) (1175773)
- Norvenlafaxine succinate
- デスベンラファキシンコハク酸塩水和物
- デスベンラファキシンコハク酸塩水和物 (JAN)